Calcium-activated chloride channel regulator 1

NameCalcium-activated chloride channel regulator 1
Synonyms
  • 3.4.-.-
  • CaCC-1
  • CACC1
  • Calcium-activated chloride channel family member 1
  • Calcium-activated chloride channel protein 1
  • hCaCC-1
  • hCLCA1
Gene NameCLCA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013969|Calcium-activated chloride channel regulator 1
MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQA
SLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTE
QMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNG
RIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFA
QHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLL
QIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELI
QINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISG
CFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNG
AVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQG
GFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKD
TSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSR
YFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDD
VQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDY
DHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDL
FIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILK
IMWKWIGELQLSIA
Number of residues914
Molecular Weight100224.765
Theoretical pINot Available
GO Classification
Functions
  • intracellular calcium activated chloride channel activity
  • chloride channel activity
  • metallopeptidase activity
  • metal ion binding
Processes
  • ion transmembrane transport
  • chloride transmembrane transport
  • transport
  • calcium ion transport
  • chloride transport
  • transmembrane transport
Components
  • secretory granule
  • microvillus
  • plasma membrane
  • extracellular space
  • integral component of plasma membrane
General FunctionMetallopeptidase activity
Specific FunctionMay be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDA8K7I4
UniProtKB Entry NameCLCA1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0013970|Calcium-activated chloride channel regulator 1 (CLCA1)
ATGGGGCCATTTAAGAGTTCTGTGTTCATCTTGATTCTTCACCTTCTAGAAGGGGCCCTG
AGTAATTCACTCATTCAGCTGAACAACAATGGCTATGAAGGCATTGTCGTTGCAATCGAC
CCCAATGTGCCAGAAGATGAAACACTCATTCAACAAATAAAGGACATGGTGACCCAGGCA
TCTCTGTATCTGTTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTGCCATTTTG
ATTCCTGAAACATGGAAGACAAAGGCTGACTATGTGAGACCAAAACTTGAGACCTACAAA
AATGCTGATGTTCTGGTTGCTGAGTCTACTCCTCCAGGTAATGATGAACCCTACACTGAG
CAGATGGGCAACTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATTTCATTGCA
GGAAAAAAGTTAGCTGAATATGGACCACAAGGTAGGGCATTTGTCCATGAGTGGGCTCAT
CTACGATGGGGAGTATTTGACGAGTACAATAATGATGAGAAATTCTACTTATCCAATGGA
AGAATACAAGCAGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAAAGAAGTGT
CAGGGAGGCAGCTGTTACACCAAAAGATGCACATTCAATAAAGTAACAGGACTCTATGAA
AAAGGATGTGAGTTTGTTCTCCAATCCCGCCAGACGGAGAAGGCTTCTATAATGTTTGCA
CAACATGTTGATTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAGAAGCTCCA
AACAAGCAAAATCAAAAATGCAATCTCCGAAGCACATGGGAAGTGATCCGTGATTCTGAG
GACTTTAAGAAAACCACTCCTATGACAACACAGCCACCAAATCCCACCTTCTCATTGCTG
CAGATTGGACAAAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGGCGACTGGT
AACCGCCTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCTGCTGCAGACAGTTGAGCTG
GGGTCCTGGGTTGGGATGGTGACATTTGACAGTGCTGCCCATGTACAAAATGAACTCATA
CAGATAAACAGTGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAGCAGCTTCA
GGAGGGACGTCCATCTGCAGCGGGCTTCGATCGGCATTTACTGTGATTAGGAAGAAATAT
CCAACTGATGGATCTGAAATTGTGCTGCTGACGGATGGGGAAGACAACACTATAAGTGGG
TGCTTTAACGAGGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGGGGCCCTCT
GCAGCTCAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGGTTTACAGACATATGCTTCA
GATCAAGTTCAGAACAATGGCCTCATTGATGCTTTTGGGGCCCTTTCATCAGGAAATGGA
GCTGTCTCTCAGCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGAACAGCCAG
TGGATGAATGGCACAGTGATCGTGGACAGCACCGTGGGAAAGGACACTTTGTTTCTTATC
ACCTGGACAATGCAGCCTCCCCAAATCCTTCTCTGGGATCCCAGTGGACAGAAGCAAGGT
GGCTTTGTAGTGGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCATTGCTAAG
GTTGGCACTTGGAAATACAGTCTGCAAGCAAGCTCACAAACCTTGACCCTGACTGTCACG
TCCCGTGCGTCCAATGCTACCCTGCCTCCAATTACAGTGACTTCCAAAACGAACAAGGAC
ACCAGCAAATTCCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAGCCTCCCCA
ATTCTCAGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAATGGAAAAACAGTTACCTTG
GAACTACTGGATAATGGAGCAGGTGCTGATGCTACTAAGGATGACGGTGTCTACTCAAGG
TATTTCACAACTTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTCTGGGAGGA
GTTAACGCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGGAGCACTGTACATACCTGGC
TGGATTGAGAATGATGAAATACAATGGAATCCACCAAGACCTGAAATTAATAAGGATGAT
GTTCAACACAAGCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTGTGGCTTCT
GATGTCCCAAATGCTCCCATACCTGATCTCTTCCCACCTGGCCAAATCACCGACCTGAAG
GCGGAAATTCACGGGGGCAGTCTCATTAATCTGACTTGGACAGCTCCTGGGGATGATTAT
GACCATGGAACAGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTGATCTCAGA
GACAAGTTCAATGAATCTCTTCAAGTGAATACTACTGCTCTCATCCCAAAGGAAGCCAAC
TCTGAGGAAGTCTTTTTGTTTAAACCAGAAAACATTACTTTTGAAAATGGCACAGATCTT
TTCATTGCTATTCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCAACATTGCA
CGAGTATCTTTGTTTATTCCTCCACAGACTCCGCCAGAGACACCTAGTCCTGATGAAACG
TCTGCTCCTTGTCCTAATATTCATATCAACAGCACCATTCCTGGCATTCACATTTTAAAA
ATTATGTGGAAGTGGATAGGAGAACTGCAGCTGTCAATAGCCTAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2015
Chromosome Location1
LocusNot Available
References
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