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NameChloride intracellular channel protein 1
Synonyms
  • Chloride channel ABP
  • G6
  • hRNCC
  • NCC27
  • Nuclear chloride ion channel 27
  • Regulatory nuclear chloride ion channel protein
Gene NameCLIC1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017672|Chloride intracellular channel protein 1
MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCP
GGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKN
SNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNL
LPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKAL
K
Number of residues241
Molecular Weight26922.47
Theoretical pINot Available
GO Classification
Functions
  • voltage-gated ion channel activity
  • chloride channel activity
Processes
  • platelet aggregation
  • chloride transmembrane transport
  • regulation of mitochondrial membrane potential
  • positive regulation of osteoblast differentiation
  • signal transduction
  • chloride transport
  • regulation of cell cycle
Components
  • nuclear membrane
  • perinuclear region of cytoplasm
  • blood microparticle
  • cytoplasm
  • mitochondrion
  • nuclear envelope
  • membrane
  • chloride channel complex
  • brush border
  • nucleus
  • plasma membrane
  • extracellular space
  • vesicle
  • extracellular exosome
General FunctionVoltage-gated ion channel activity
Specific FunctionCan insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.
Pfam Domain Function
Transmembrane Regions26-46
GenBank Protein IDNot Available
UniProtKB IDO00299
UniProtKB Entry NameCLIC1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0017673|Chloride intracellular channel protein 1 (CLIC1)
ATGGCTGAAGAACAACCGCAGGTCGAATTGTTCGTGAAGGCTGGCAGTGATGGGGCCAAG
ATTGGGAACTGCCCATTCTCCCAGAGACTGTTCATGGTACTGTGGCTCAAGGGAGTCACC
TTCAATGTTACCACCGTTGACACCAAAAGGCGGACCGAGACAGTGCAGAAGCTGTGCCCA
GGGGGGCAGCTCCCATTCCTGCTGTATGGCACTGAAGTGCACACAGACACCAACAAGATT
GAGGAATTTCTGGAGGCAGTGCTGTGCCCTCCCAGGTACCCCAAGCTGGCAGCTCTGAAC
CCTGAGTCCAACACAGCTGGGCTGGACATATTTGCCAAATTTTCTGCCTACATCAAGAAT
TCAAACCCAGCACTCAATGACAATCTGGAGAAGGGACTCCTGAAAGCCCTGAAGGTTTTA
GACAATTACTTAACATCCCCCCTCCCAGAAGAAGTGGATGAAACCAGTGCTGAAGATGAA
GGTGTCTCTCAGAGGAAGTTTTTGGATGGCAACGAGCTCACCCTGGCTGACTGCAACCTG
TTGCCAAAGTTACACATAGTACAGGTGGTGTGTAAGAAGTACCGGGGATTCACCATCCCC
GAGGCCTTCCGGGGAGTGCATCGGTACTTGAGCAATGCCTACGCCCGGGAAGAATTCGCT
TCCACCTGTCCAGATGATGAGGAGATCGAGCTCGCCTATGAGCAAGTGGCAAAGGCCCTC
AAATAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2062
Chromosome Location6
LocusNot Available
References
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  7. Tonini R, Ferroni A, Valenzuela SM, Warton K, Campbell TJ, Breit SN, Mazzanti M: Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells. FASEB J. 2000 Jun;14(9):1171-8. 10834939
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