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NameMonocarboxylate transporter 5
Synonyms
  • MCT 4
  • MCT 5
  • MCT4
  • MCT5
  • Monocarboxylate transporter 4
  • Solute carrier family 16 member 4
Gene NameSLC16A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000389|Monocarboxylate transporter 5
MLKREGKVQPYTKTLDGGWGWMIVIHFFLVNVFVMGMTKTFAIFFVVFQEEFEGTSEQIG
WIGSIMSSLRFCAGPLVAIICDILGEKTTSILGAFVVTGGYLISSWATSIPFLCVTMGLL
PGLGSAFLYQVAAVVTTKYFKKRLALSTAIARSGMGLTFLLAPFTKFLIDLYDWTGALIL
FGAIALNLVPSSMLLRPIHIKSENNSGIKDKGSSLSAHGPEAHATETHCHETEESTIKDS
TTQKAGLPSKNLTVSQNQSEEFYNGPNRNRLLLKSDEESDKVISWSCKQLFDISLFRNPF
FYIFTWSFLLSQLAYFIPTFHLVARAKTLGIDIMDASYLVSVAGILETVSQIISGWVADQ
NWIKKYHYHKSYLILCGITNLLAPLATTFPLLMTYTICFAIFAGGYLALILPVLVDLCRN
STVNRFLGLASFFAGMAVLSGPPIAGWLYDYTQTYNGSFYFSGICYLLSSVSFFFVPLAE
RWKNSLT
Number of residues487
Molecular Weight54021.43
Theoretical pI8.13
GO Classification
Functions
  • symporter activity
  • monocarboxylic acid transmembrane transporter activity
Processes
  • ion transmembrane transport
  • monocarboxylic acid transport
Components
  • membrane
  • integral component of plasma membrane
General FunctionSymporter activity
Specific FunctionProton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Pfam Domain Function
Transmembrane Regions17-37 60-80 88-108 110-129 144-164 175-195 300-320 338-358 373-393 395-415 426-446 459-479
GenBank Protein ID2463628
UniProtKB IDO15374
UniProtKB Entry NameMOT5_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016030|Monocarboxylate transporter 5 (SLC16A4)
ATGCTGAAGAGGGAGGGGAAGGTCCAACCTTACACTAAAACCCTGGATGGAGGATGGGGA
TGGATGATTGTGATTCATTTTTTCCTGGTGAATGTGTTTGTGATGGGGATGACCAAGACT
TTTGCAATTTTCTTTGTGGTCTTTCAAGAAGAGTTTGAAGGCACCTCAGAGCAAATTGGT
TGGATTGGATCCATCATGTCATCTCTTCGTTTTTGTGCAGGTTTGGGTTCTGCTTTCTTA
TACCAAGTGGCTGCTGTGGTAACTACCAAATACTTCAAAAAACGATTGGCTCTTTCTACA
GCTATTGCCCGTTCTGGGATGGGACTGACTTTTCTTTTGGCACCCTTTACAAAATTCCTG
ATAGATCTGTATGACTGGACAGGAGCCCTTATATTATTTGGAGCTATCGCATTGAATTTG
GTGCCTTCTAGTATGCTCTTAAGACCCATCCATATCAAAAGTGAGAACAATTCTGGTATT
AAAGATAAAGGCAGCAGTTTGTCTGCACATGGTCCAGAGGCACATGCAACAGAAACACAC
TGCCATGAGACAGAAGAGTCTACCATCAAGGACAGTACTACGCAGAAGGCTGGACTACCT
AGCAAAAATTTAACAGTCTCACAAAATCAAAGTGAAGAGTTCTACAATGGGCCTAACAGG
AACAGACTGTTATTAAAGAGTGATGAAGAAAGTGATAAGGTTATTTCGTGGAGCTGCAAA
CAACTGTTTGACATTTCTCTCTTTAGAAATCCTTTCTTCTACATATTTACTTGGTCTTTT
CTCCTCAGTCAGTTAGCATACTTCATCCCTACCTTTCACCTGGTAGCCAGAGCCAAAACA
CTGGGGATTGACATCATGGATGCCTCTTACCTTGTTTCTGTAGCAGGTATCCTTGAGACG
GTCAGTCAGATTATTTCTGGATGGGTTGCTGATCAAAACTGGATTAAGAAGTATCATTAC
CACAAGTCTTACCTCATCCTCTGCGGCATCACTAACCTGCTTGCTCCTTTAGCCACCACA
TTTCCACTACTTATGACCTACACCATCTGCTTTGCCATCTTTGCTGGTGGTTACCTGGCA
TTGATACTGCCTGTACTGGTTGATCTGTGTAGGAATTCTACAGTAAACAGGTTTTTGGGA
CTTGCCAGTTTCTTTGCTGGGATGGCTGTCCTTTCTGGACCACCTATAGCAGGCTGGTTA
TATGATTATACCCAGACATACAATGGCTCTTTCTACTTCTCTGGCATATGCTATCTCCTC
TCTTCAGTTTCCTTTTTTTTTGTACCATTGGCCGAAAGATGGAAAAACAGTCTGACCTGA
GenBank Gene IDU59185
GeneCard IDNot Available
GenAtlas IDSLC16A4
HGNC IDHGNC:10925
Chromosome Location1
Locus1p13.3
References
  1. Price NT, Jackson VN, Halestrap AP: Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J. 1998 Jan 15;329 ( Pt 2):321-8. 9425115
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