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NameFatty acid-binding protein, brain
Synonyms
  • B-FABP
  • BLBP
  • Brain lipid-binding protein
  • Brain-type fatty acid-binding protein
  • FABPB
  • Fatty acid-binding protein 7
  • Mammary-derived growth inhibitor related
  • MRG
Gene NameFABP7
OrganismHuman
Amino acid sequence
>lcl|BSEQ0003608|Fatty acid-binding protein, brain
MVEAFCATWKLTNSQNFDEYMKALGVGFATRQVGNVTKPTVIISQEGDKVVIRTLSTFKN
TEISFQLGEEFDETTADDRNCKSVVSLDGDKLVHIQKWDGKETNFVREIKDGKMVMTLTF
GDVVAVRHYEKA
Number of residues132
Molecular Weight14888.855
Theoretical pI5.25
GO Classification
Functions
  • transporter activity
  • lipid binding
Processes
  • nervous system development
  • cell proliferation in forebrain
  • prepulse inhibition
  • triglyceride catabolic process
  • neurogenesis
  • epithelial cell proliferation
  • small molecule metabolic process
  • negative regulation of cell proliferation
Components
  • neuronal cell body
  • cell-cell junction
  • cell projection
  • cell periphery
  • cytoplasm
  • cytosol
  • nucleoplasm
General FunctionTransporter activity
Specific FunctionB-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2632065
UniProtKB IDO15540
UniProtKB Entry NameFABP7_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021304|Fatty acid-binding protein, brain (FABP7)
ATGGTGGAGGCTTTCTGTGCTACCTGGAAGCTGACCAACAGTCAGAACTTTGATGAGTAC
ATGAAGGCTCTAGGCGTGGGCTTTGCCACTAGGCAGGTGGGAAATGTGACCAAACCAACG
GTAATTATCAGTCAAGAAGGAGACAAAGTGGTCATCAGGACTCTCAGCACATTCAAGAAC
ACGGAGATTAGTTTCCAGCTGGGAGAAGAGTTTGATGAAACCACTGCAGATGATAGAAAC
TGTAAGTCTGTTGTTAGCCTGGATGGAGACAAACTTGTTCACATACAGAAATGGGATGGC
AAAGAAACAAATTTTGTAAGAGAAATTAAGGATGGCAAAATGGTTATGACCCTTACTTTT
GGTGATGTGGTTGCTGTTCGCCACTATGAGAAGGCATAA
GenBank Gene IDAJ002962
GeneCard IDNot Available
GenAtlas IDFABP7
HGNC IDHGNC:3562
Chromosome Location6
Locus6q22-q23
References
  1. Shimizu F, Watanabe TK, Shinomiya H, Nakamura Y, Fujiwara T: Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP). Biochim Biophys Acta. 1997 Oct 9;1354(1):24-8. 9375786
  2. Godbout R, Bisgrove DA, Shkolny D, Day RS 3rd: Correlation of B-FABP and GFAP expression in malignant glioma. Oncogene. 1998 Apr 16;16(15):1955-62. 9591779
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