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NamePeptidyl-prolyl cis-trans isomerase H
Synonyms
  • 5.2.1.8
  • CYP20
  • CYPH
  • PPIase H
  • Rotamase H
  • Small nuclear ribonucleoprotein particle-specific cyclophilin H
  • U-snRNP-associated cyclophilin SnuCyp-20
  • USA-CYP
Gene NamePPIH
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004577|Peptidyl-prolyl cis-trans isomerase H
MAVANSSPVNPVVFFDVSIGGQEVGRMKIELFADVVPKTAENFRQFCTGEFRKDGVPIGY
KGSTFHRVIKDFMIQGGDFVNGDGTGVASIYRGPFADENFKLRHSAPGLLSMANSGPSTN
GCQFFITCSKCDWLDGKHVVFGKIIDGLLVMRKIENVPTGPNNKPKLPVVISQCGEM
Number of residues177
Molecular Weight19208.04
Theoretical pI8.22
GO Classification
Functions
  • peptidyl-prolyl cis-trans isomerase activity
  • cyclosporin A binding
  • ribonucleoprotein complex binding
Processes
  • protein complex assembly
  • protein peptidyl-prolyl isomerization
  • positive regulation of viral genome replication
  • mRNA splicing, via spliceosome
  • protein folding
Components
  • nuclear speck
  • spliceosomal complex
  • U4/U6 snRNP
  • U4/U6 x U5 tri-snRNP complex
  • cytoplasm
General FunctionRibonucleoprotein complex binding
Specific FunctionPPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2708309
UniProtKB IDO43447
UniProtKB Entry NamePPIH_HUMAN
Cellular LocationNucleus speckle
Gene sequence
>lcl|BSEQ0016759|Peptidyl-prolyl cis-trans isomerase H (PPIH)
ATGGCGGTGGCAAATTCAAGTCCTGTTAACCCCGTGGTGTTCTTTGATGTCAGTATTGGC
GGTCAGGAAGTTGGCCGCATGAAGATCGAGCTCTTTGCAGACGTTGTGCCTAAGACGGCC
GAGAACTTTAGGCAGTTCTGCACCGGAGAATTCAGGAAAGATGGGGTTCCAATAGGATAC
AAAGGAAGCACCTTCCACAGGGTCATAAAGGATTTCATGATTCAGGGTGGAGATTTTGTT
AATGGAGATGGTACTGGAGTCGCCAGTATTTACCGGGGGCCATTTGCAGATGAAAATTTT
AAACTTAGACACTCAGCTCCAGGCCTGCTTTCCATGGCGAACAGTGGTCCAAGTACAAAT
GGCTGTCAGTTCTTTATCACCTGCTCTAAGTGCGATTGGCTGGATGGGAAGCATGTGGTG
TTTGGAAAAATCATCGATGGACTTCTAGTGATGAGAAAGATTGAGAATGTTCCCACAGGC
CCCAACAATAAGCCCAAGCTACCTGTGGTGATCTCGCAGTGTGGGGAGATGTAG
GenBank Gene IDAF016371
GeneCard IDNot Available
GenAtlas IDPPIH
HGNC IDHGNC:14651
Chromosome Location1
Locus1p34.1
References
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  2. Teigelkamp S, Achsel T, Mundt C, Gothel SF, Cronshagen U, Lane WS, Marahiel M, Luhrmann R: The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins. RNA. 1998 Feb;4(2):127-41. 9570313
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