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NameATPase ASNA1
Synonyms
  • 3.6.-.-
  • ARSA
  • Arsenical pump-driving ATPase
  • Arsenite-stimulated ATPase
  • hARSA-I
  • hASNA-I
  • Transmembrane domain recognition complex 40 kDa ATPase subunit
  • TRC40
Gene NameASNA1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001496|ATPase ASNA1
MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQ
LSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFE
EDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFP
TIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPE
QTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQA
KYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSAQ
Number of residues348
Molecular Weight38792.445
Theoretical pI4.54
GO Classification
Functions
  • ATPase activity
  • metal ion binding
  • arsenite transmembrane transporter activity
  • transporter activity
  • ATP binding
Processes
  • cellular protein metabolic process
  • endoplasmic reticulum unfolded protein response
  • IRE1-mediated unfolded protein response
  • protein insertion into ER membrane
  • transport
  • inorganic anion transport
Components
  • nucleus
  • endoplasmic reticulum membrane
  • extracellular exosome
  • nucleolus
  • cytoplasm
General FunctionTransporter activity
Specific FunctionATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID2905657
UniProtKB IDO43681
UniProtKB Entry NameASNA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010528|ATPase ASNA1 (ASNA1)
ATGGCGGCAGGGGTGGCCGGGTGGGGGGTTGAGGCAGAGGAGTTCGAAGATGCTCCTGAT
GTGGAGCCGCTGGAGCCTACACTTAGCAACATCATCGAGCAGCGCAGCCTGAAGTGGATC
TTCGTCGGGGGCAAGGGTGGTGTGGGCAAGACCACCTGCAGCTGCAGCCTGGCAGTCCAG
CTCTCCAAGGGGCGTGAGAGTGTTCTGATCATCTCCACAGACCCAGCACACAACATCTCA
GATGCTTTTGACCAGAAGTTCTCAAAGGTGCCTACCAAGGTCAAAGGCTATGACAACCTC
TTTGCTATGGAGATTGACCCCAGCCTGGGCGTGGCGGAGCTGCCTGACGAGTTCTTCGAG
GAGGACAACATGCTGAGCATGGGCAAGAAGATGATGCAGGAGGCCATGAGCGCATTTCCC
GGCATCGATGAGGCCATGAGCTATGCCGAGGTCATGAGGCTGGTGAAGGGCATGAACTTC
TCGGTGGTGGTATTTGACACGGCACCCACGGGCCACACCCTGAGGCTGCTCAACTTCCCC
ACCATCGTGGAGCGGGGCCTGGGCCGGCTTATGCAGATCAAGAACCAGATCAGCCCTTTC
ATCTCACAGATGTGCAACATGCTGGGCCTGGGGGACATGAACGCAGACCAGCTGGCCTCC
AAGCTGGAGGAGACGCTGCCCGTCATCCGCTCAGTCAGCGAACAGTTCAAGGACCCTGAG
CAGACAACTTTCATCTGCGTATGCATTGCTGAGTTCCTGTCCCTGTATGAGACAGAGAGG
CTGATCCAGGAGCTGGCCAAGTGCAAGATTGACACACACAATATAATTGTCAACCAGCTC
GTCTTCCCCGACCCCGAGAAGCCCTGCAAGATGTGTGAGGCCCGTCACAAGATCCAGGCC
AAGTATCTGGACCAGATGGAGGACCTGTATGAAGACTTCCACATCGTGAAGCTGCCGCTG
TTACCCCATGAGGTGCGGGGGGCAGACAAGGTCAACACCTTCTCGGCCCTCCTCCTGGAG
CCCTACAAGCCCCCCAGTGCCCAGTAG
GenBank Gene IDAF047469
GeneCard IDNot Available
GenAtlas IDASNA1
HGNC IDHGNC:752
Chromosome Location19
Locus19q13.3
References
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