SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

NameSWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
Synonyms
  • 3.6.4.-
  • hSNF2H
  • SNF2H
  • Sucrose nonfermenting protein 2 homolog
  • SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5
  • WCRF135
Gene NameSMARCA5
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019595|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5
MSSAAEPPPPPPPESAPSKPAASIASGGSNSSNKGGPEGVAAQAVASAASAGPADAEMEE
IFDDASPGKQKEIQEPDPTYEEKMQTDRANRFEYLLKQTELFAHFIQPAAQKTPTSPLKM
KPGRPRIKKDEKQNLLSVGDYRHRRTEQEEDEELLTESSKATNVCTRFEDSPSYVKWGKL
RDYQVRGLNWLISLYENGINGILADEMGLGKTLQTISLLGYMKHYRNIPGPHMVLVPKST
LHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEWDVCVTSYEMLIKEKSVFKKF
NWRYLVIDEAHRIKNEKSKLSEIVREFKTTNRLLLTGTPLQNNLHELWSLLNFLLPDVFN
SADDFDSWFDTNNCLGDQKLVERLHMVLRPFLLRRIKADVEKSLPPKKEVKIYVGLSKMQ
REWYTRILMKDIDILNSAGKMDKMRLLNILMQLRKCCNHPYLFDGAEPGPPYTTDMHLVT
NSGKMVVLDKLLPKLKEQGSRVLIFSQMTRVLDILEDYCMWRNYEYCRLDGQTPHDERQD
SINAYNEPNSTKFVFMLSTRAGGLGINLATADVVILYDSDWNPQVDLQAMDRAHRIGQTK
TVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQNLNKIGKDEMLQMIRHGATH
VFASKESEITDEDIDGILERGAKKTAEMNEKLSKMGESSLRNFTMDTESSVYNFEGEDYR
EKQKIAFTEWIEPPKRERKANYAVDAYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPR
LFELLEKEILFYRKTIGYKVPRNPELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQ
GFTNWNKRDFNQFIKANEKWGRDDIENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKI
MAQIERGEARIQRRISIKKALDTKIGRYKAPFHQLRISYGTNKGKNYTEEEDRFLICMLH
KLGFDKENVYDELRQCIRNSPQFRFDWFLKSRTAMELQRRCNTLITLIERENMELEEKEK
AEKKKRGPKPSTQKRKMDGAPDGRGRKKKLKL
Number of residues1052
Molecular Weight121904.335
Theoretical pINot Available
GO Classification
Functions
  • ATP binding
  • DNA binding
  • ATPase activity
  • helicase activity
Processes
  • double-strand break repair
  • regulation of transcription from RNA polymerase II promoter
  • negative regulation of gene expression, epigenetic
  • regulation of gene expression, epigenetic
  • ATP-dependent chromatin remodeling
  • chromatin remodeling
  • chromatin silencing at rDNA
  • nucleosome assembly
  • DNA repair
  • CENP-A containing nucleosome assembly
  • nucleosome positioning
  • DNA-templated transcription, initiation
  • gene expression
Components
  • condensed chromosome
  • nucleus
  • NURF complex
  • chromatin silencing complex
  • RSF complex
  • nucleolus
  • nucleoplasm
General FunctionHelicase activity
Specific FunctionHelicase that possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO60264
UniProtKB Entry NameSMCA5_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0019596|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)
ATGTCGTCCGCGGCCGAGCCTCCGCCACCCCCGCCTCCCGAGAGCGCGCCTTCCAAGCCC
GCAGCCTCGATCGCCAGCGGCGGGAGCAACAGCAGCAACAAAGGCGGCCCCGAAGGCGTC
GCGGCGCAGGCGGTTGCGTCTGCGGCCAGCGCTGGTCCCGCAGACGCCGAGATGGAGGAA
ATATTTGATGATGCGTCACCTGGAAAGCAAAAGGAAATCCAAGAACCAGATCCTACCTAT
GAAGAAAAAATGCAAACTGACCGGGCAAATAGATTCGAGTATTTATTAAAGCAGACAGAA
CTTTTTGCACATTTCATTCAACCTGCTGCTCAGAAGACTCCAACTTCACCTTTGAAGATG
AAACCAGGGCGCCCACGAATAAAAAAAGATGAGAAGCAGAACTTACTATCCGTTGGCGAT
TACCGACACCGTAGAACAGAGCAAGAGGAGGATGAAGAGCTATTAACAGAAAGCTCCAAA
GCAACCAATGTTTGCACTCGATTTGAAGACTCTCCATCGTATGTAAAATGGGGTAAACTG
AGAGATTATCAGGTCCGAGGATTAAACTGGCTCATTTCTTTGTATGAGAATGGCATCAAT
GGTATCCTTGCAGATGAAATGGGCCTAGGAAAGACTCTTCAAACAATTTCTCTTCTTGGG
TACATGAAACATTATAGAAACATTCCTGGGCCTCATATGGTTTTGGTTCCTAAGTCTACA
TTACACAACTGGATGAGTGAATTCAAGAGATGGGTACCAACACTTAGATCTGTTTGTTTG
ATAGGAGATAAAGAACAAAGAGCTGCTTTTGTCAGAGACGTTTTATTACCGGGAGAATGG
GATGTATGTGTAACATCTTATGAAATGCTTATTAAAGAGAAGTCTGTGTTCAAAAAATTT
AATTGGAGATACTTAGTAATAGATGAAGCTCACAGGATCAAAAATGAAAAATCTAAGTTG
TCAGAAATAGTGAGGGAATTCAAGACTACAAATAGACTATTATTAACTGGAACACCTCTT
CAGAACAACTTGCATGAGCTGTGGTCACTTCTTAACTTTCTGTTGCCAGATGTGTTTAAT
TCAGCAGATGACTTTGATTCCTGGTTTGATACAAACAACTGCCTTGGGGATCAAAAACTA
GTTGAGAGGCTTCATATGGTTTTGCGTCCATTCCTCCTTCGTCGAATTAAGGCTGATGTT
GAAAAGAGTTTGCCTCCAAAGAAGGAAGTAAAAATCTATGTGGGCCTCAGCAAAATGCAA
AGGGAATGGTATACTCGGATATTAATGAAGGATATAGATATACTCAACTCAGCAGGCAAG
ATGGACAAAATGAGGTTATTGAACATCCTAATGCAGTTGAGAAAATGTTGTAATCATCCA
TATCTCTTTGATGGAGCAGAACCTGGTCCACCTTATACAACAGATATGCATCTAGTAACC
AACAGTGGCAAAATGGTGGTTTTAGACAAGCTGCTCCCTAAGTTAAAAGAACAAGGTTCA
CGAGTACTAATCTTCAGTCAAATGACAAGGGTATTGGACATTTTGGAAGATTATTGCATG
TGGAGAAATTATGAGTACTGCAGGTTGGATGGTCAGACACCCCATGATGAGAGACAAGAC
TCCATCAATGCATACAATGAACCAAACAGCACAAAGTTTGTTTTCATGTTAAGCACGCGT
GCTGGTGGTCTTGGCATCAATCTTGCGACTGCTGATGTAGTAATTTTGTATGATTCTGAT
TGGAATCCCCAAGTAGATCTTCAGGCTATGGACCGAGCACATAGAATTGGGCAGACTAAG
ACAGTCAGAGTGTTCCGCTTTATAACTGATAACACTGTAGAAGAAAGAATAGTAGAACGT
GCTGAGATGAAACTCAGACTGGATTCAATAGTCATTCAACAAGGGAGGCTTGTGGATCAG
AATCTGAACAAAATTGGGAAAGATGAAATGCTTCAAATGATTAGACATGGAGCAACACAT
GTGTTTGCTTCAAAGGAAAGTGAGATCACTGATGAAGATATCGATGGTATTTTGGAAAGA
GGTGCAAAGAAGACTGCAGAGATGAATGAAAAGCTCTCCAAGATGGGCGAAAGTTCACTT
AGAAACTTTACAATGGATACAGAGTCAAGTGTTTATAACTTCGAAGGAGAAGACTATAGA
GAAAAACAAAAGATTGCATTCACAGAGTGGATTGAACCACCTAAACGAGAAAGAAAAGCC
AACTATGCCGTTGATGCATATTTCAGGGAAGCTCTTCGTGTTAGTGAACCTAAAGCACCC
AAGGCTCCTCGACCTCCAAAACAACCCAATGTTCAGGATTTCCAGTTCTTTCCTCCACGT
TTATTTGAATTACTGGAAAAAGAAATTCTGTTTTACAGAAAAACTATTGGGTACAAGGTA
CCTCGAAATCCTGAGCTGCCTAACGCAGCACAGGCACAAAAAGAAGAACAGCTTAAAATT
GATGAAGCTGAATCCCTTAATGATGAAGAGTTAGAGGAAAAAGAGAAGCTTCTAACACAG
GGATTTACCAATTGGAATAAGAGAGATTTTAACCAGTTTATCAAAGCTAATGAGAAGTGG
GGTCGTGATGATATTGAAAATATAGCAAGAGAAGTAGAAGGCAAAACTCCAGAAGAAGTC
ATTGAATATTCAGCTGTGTTTTGGGAAAGGTGCAACGAGCTCCAGGACATAGAGAAGATT
ATGGCTCAGATTGAAAGGGGAGAGGCGAGAATTCAAAGAAGAATAAGCATCAAGAAAGCA
CTTGACACAAAGATTGGACGGTACAAAGCACCTTTTCATCAGCTGAGAATATCATATGGT
ACTAACAAAGGAAAAAACTATACTGAAGAAGAAGATCGTTTTCTGATTTGTATGCTTCAC
AAACTTGGATTTGACAAAGAAAATGTTTATGATGAATTGCGACAGTGTATTCGCAACTCT
CCTCAGTTCAGATTTGACTGGTTTCTTAAGTCCAGAACTGCAATGGAGCTCCAGAGGAGA
TGTAATACCTTAATTACTTTGATTGAAAGAGAAAACATGGAACTAGAAGAAAAGGAGAAG
GCAGAGAAAAAGAAACGAGGACCAAAGCCTTCAACACAGAAACGTAAAATGGATGGCGCA
CCTGATGGTCGAGGAAGAAAAAAGAAGCTGAAACTATGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11101
Chromosome Location4
LocusNot Available
References
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