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NameHistone H2B type 1-K
Synonyms
  • H2B K
  • H2BFT
  • HIRA-interacting protein 1
  • HIRIP1
Gene NameHIST1H2BK
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013505|Histone H2B type 1-K
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSAK
Number of residues126
Molecular Weight13890.035
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • nucleosome assembly
  • antibacterial humoral response
  • defense response to Gram-positive bacterium
  • innate immune response in mucosa
  • chromatin organization
Components
  • cytoplasm
  • nucleus
  • extracellular space
  • nucleoplasm
  • nuclear nucleosome
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO60814
UniProtKB Entry NameH2B1K_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013506|Histone H2B type 1-K (HIST1H2BK)
ATGCCGGAACCAGCGAAGTCCGCTCCCGCGCCCAAGAAGGGCTCGAAGAAAGCCGTGACT
AAGGCGCAGAAGAAGGACGGCAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTACTCCGTA
TACGTGTACAAGGTGCTGAAGCAGGTCCACCCCGACACCGGCATCTCCTCTAAGGCCATG
GGAATCATGAACTCCTTCGTCAACGACATCTTCGAACGCATCGCGGGTGAGGCTTCCCGC
CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC
CTGCTGCTGCCCGGGGAGTTGGCCAAGCACGCCGTGTCCGAGGGCACCAAGGCCGTCACC
AAGTACACCAGCGCTAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:13954
Chromosome Location6
LocusNot Available
References
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