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NameProtein phosphatase 1 regulatory subunit 11
Synonyms
  • HCG V
  • HCGV
  • Hemochromatosis candidate gene V protein
  • Protein phosphatase inhibitor 3
  • TCTE5
Gene NamePPP1R11
OrganismHuman
Amino acid sequence
>lcl|BSEQ0017692|Protein phosphatase 1 regulatory subunit 11
MAEAGAGLSETVTETTVTVTTEPENRSLTIKLRKRKPEKKVEWTSDTVDNEHMGRRSSKC
CCIYEKPRAFGESSTESDEEEEEGCGHTHCVRGHRKGRRRATLGPTPTTPPQPPDPSQPP
PGPMQH
Number of residues126
Molecular Weight13952.425
Theoretical pINot Available
GO Classification
Functions
  • protein serine/threonine phosphatase inhibitor activity
  • protein phosphatase 1 binding
Processes
  • negative regulation of protein dephosphorylation
  • negative regulation of phosphoprotein phosphatase activity
Components
  • protein phosphatase type 1 complex
  • cytoplasm
  • nucleus
General FunctionProtein serine/threonine phosphatase inhibitor activity
Specific FunctionInhibitor of protein phosphatase 1.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDO60927
UniProtKB Entry NamePP1RB_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0017693|Protein phosphatase 1 regulatory subunit 11 (PPP1R11)
ATGGCCGAGGCAGGGGCTGGGCTGAGCGAGACCGTCACTGAGACAACGGTTACCGTGACA
ACCGAGCCCGAGAACCGGAGCCTTACCATCAAACTTCGGAAACGGAAGCCAGAGAAAAAG
GTAGAATGGACAAGTGACACTGTGGACAATGAACACATGGGCCGCCGCTCATCCAAATGC
TGCTGTATTTATGAGAAACCTCGGGCCTTTGGCGAGAGCTCCACGGAAAGTGATGAGGAG
GAAGAAGAGGGCTGTGGTCATACACACTGTGTACGTGGCCACCGCAAAGGACGGCGTCGT
GCAACCCTAGGACCGACCCCCACCACCCCTCCCCAGCCTCCTGACCCTTCCCAGCCCCCT
CCAGGGCCAATGCAGCACTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9285
Chromosome Location6
LocusNot Available
References
  1. Giffon T, Lepourcelet M, Pichon L, Jezequel P, Bouric P, Carn G, Pontarotti P, Gall JY, David V: Cloning of a human homologue of the mouse Tctex-5 gene within the MHC class I region. Immunogenetics. 1996;44(5):331-9. 8781118
  2. Lepourcelet M, Andrieux N, Giffon T, Pichon L, Hampe A, Galibert F, Mosser J: Systematic sequencing of the human HLA-A/HLA-F region: establishment of a cosmid contig and identification of a new gene cluster within 37 kb of sequence. Genomics. 1996 Nov 1;37(3):316-26. 8938444
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  5. Zhang J, Zhang L, Zhao S, Lee EY: Identification and characterization of the human HCG V gene product as a novel inhibitor of protein phosphatase-1. Biochemistry. 1998 Nov 24;37(47):16728-34. 9843442
  6. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648
  7. Olsen JV, Vermeulen M, Santamaria A, Kumar C, Miller ML, Jensen LJ, Gnad F, Cox J, Jensen TS, Nigg EA, Brunak S, Mann M: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. Sci Signal. 2010 Jan 12;3(104):ra3. doi: 10.1126/scisignal.2000475. 20068231
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