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SEC14-like protein 2

NameSEC14-like protein 2
Synonyms
  • Alpha-tocopherol-associated protein
  • C22orf6
  • hTAP
  • KIAA1186
  • KIAA1658
  • SPF
  • Squalene transfer protein
  • Supernatant protein factor
  • TAP
Gene NameSEC14L2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000511|SEC14-like protein 2
MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHV
EFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDL
LRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEE
NYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVE
YGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPG
CVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGI
YVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK
Number of residues403
Molecular Weight46144.9
Theoretical pI7.94
GO Classification
Functions
  • transporter activity
  • transferase activity, transferring alkyl or aryl (other than methyl) groups
  • phospholipid binding
  • enzyme activator activity
  • vitamin E binding
Processes
  • positive regulation of cholesterol biosynthetic process
  • positive regulation of transcription, DNA-templated
  • regulation of cholesterol biosynthetic process
  • transcription, DNA-templated
Components
  • cytoplasm
  • nucleus
  • integral component of membrane
  • cytosol
  • extracellular exosome
General FunctionVitamin e binding
Specific FunctionCarrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID5596693
UniProtKB IDO76054
UniProtKB Entry NameS14L2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016047|SEC14-like protein 2 (SEC14L2)
ATGAGCGGCAGAGTCGGCGATCTGAGCCCCAGGCAGAAGGAGGCATTGGCCAAGTTTCGG
GAGAATGTCCAGGATGTGCTGCCGGCCCTGCCGAATCCAGATGACTATTTTCTCCTGCGT
TGGCTCCGAGCCAGAAGCTTCGACCTGCAGAAGTCGGAGGCCATGCTCCGGAAGTTGGGG
AGGAAGGTGGAGACCATCACCATAATTTATGACTGCGAGGGGCTTGGCCTCAAGCATCTC
TGGAAGCCTGCTGTGGAGGCCTATGGAGAGTTTCTCTGCATGTTTGAGGAAAATTATCCC
GAAACACTGAAGCGTCTTTTTGTTGTTAAAGCCCCCAAACTGTTTCCTGTGGCCTATAAC
CTCATCAAACCCTTCCTGAGTGAGGACACTCGTAAGAAGATCATGGTCCTGGGAGCAAAT
TGGAAGGAGGTTTTACTGAAACATATCAGCCCTGACCAGGTGCCTGTGGAGTATGGGGGC
ACCATGACTGACCCTGATGGAAACCCCAAGTGCAAATCCAAGATCAACTACGGGGGTGAC
ATCCCCAGGAAGTATTATGTGCGAGACCAGGTGAAACAGCAGTATGAACACAGCGTGCAG
ATTTCCCGTGGCTCCTCCCACCAAGTGGAGTATGAGATCCTCTTCCCTGGCTGTGTCCTC
AGGTGGCAGTTTATGTCAGATGGAGCGGATGTTGGTTTTGGGATTTTCCTGAAGACCAAG
ATGGGAGAGAGGCAGCGGGCAGGGGAGATGACAGAGGTGCTGCCCAACCAGAGGTACAAC
TCCCACCTGGTCCCTGAAGATGGGACCCTCACCTGCAGTGATCCTGGCATCTATGTCCTG
CGGTTTGACAACACCTACAGCTTCATTCATGCCAAGAAGGTCAATTTCACTGTGGAGGTC
CTGCTTCCAGACAAAGCCTCAGAAGAGAAGATGAAACAGCTGGGGGCAGGCACCCCGAAA
TAA
GenBank Gene IDAL096881
GeneCard IDNot Available
GenAtlas IDSEC14L2
HGNC IDHGNC:10699
Chromosome Location22
Locus22q12.2
References
  1. Zimmer S, Stocker A, Sarbolouki MN, Spycher SE, Sassoon J, Azzi A: A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. J Biol Chem. 2000 Aug 18;275(33):25672-80. 10829015
  2. Yamauchi J, Iwamoto T, Kida S, Masushige S, Yamada K, Esashi T: Tocopherol-associated protein is a ligand-dependent transcriptional activator. Biochem Biophys Res Commun. 2001 Jul 13;285(2):295-9. 11444841
  3. Shibata N, Arita M, Misaki Y, Dohmae N, Takio K, Ono T, Inoue K, Arai H: Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2244-9. 11226224
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