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Fatty acid desaturase 2

NameFatty acid desaturase 2
Synonyms
  • 1.14.19.3
  • Acyl-CoA 6-desaturase
  • D6D
  • Delta-6 desaturase
  • Delta(6) desaturase
  • Delta(6) fatty acid desaturase
Gene NameFADS2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004408|Fatty acid desaturase 2
MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVIDRKVYNITKWSIQHPGGQRVI
GHYAGEDATDAFRAFHPDLEFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRKTA
EDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNGWIPTLITAFVLATSQAQAGWLQH
DYGHLSVYRKPKWNHLVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNMLHVFV
LGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIVHKNWVDLAWAV
SYYIRFFITYIPFYGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAYRDWFSSQL
TATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLL
RALLDIIRSLKKSGKLWLDAYLHK
Number of residues444
Molecular Weight52259.075
Theoretical pI9.18
GO Classification
Functions
  • linoleoyl-CoA desaturase activity
  • stearoyl-CoA 9-desaturase activity
Processes
  • unsaturated fatty acid biosynthetic process
  • small molecule metabolic process
  • alpha-linolenic acid metabolic process
  • unsaturated fatty acid metabolic process
  • linoleic acid metabolic process
Components
  • membrane
  • endoplasmic reticulum membrane
  • integral component of plasma membrane
General FunctionStearoyl-coa 9-desaturase activity
Specific FunctionComponent of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.
Pfam Domain Function
Transmembrane Regions132-152 158-178 265-285 306-326
GenBank Protein ID4406528
UniProtKB IDO95864
UniProtKB Entry NameFADS2_HUMAN
Cellular LocationEndoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0011620|Fatty acid desaturase 2 (FADS2)
ATGCACGGCAGGGAGGCGGGACCCTTTGTTTGTGTGTGCGTGTTGTTGGCCTCCATCCCC
ACTCCCCAGACTCCACTTCTCCAGGCCTCTCTCCCGCCTTTTCATCCCGCATCCGCAGGA
CACCCAATCACCGGGCAACAGGATGCCTTCCGCGCCTTCCACCCTGACCTGGAATTCGTG
GGCAAGTTCTTGAAACCCCTGCTGATTGGTGAACTGGCCCCGGAGGAGCCCAGCCAGGAC
CACGGCAAGAACTCAAAGATCACTGAGGACTTCCGGGCCCTGAGGAAGACGGCTGAGGAC
ATGAACCTGTTCAAGACCAACCACGTGTTCTTCCTCCTCCTCCTGGCCCACATCATCGCC
CTGGAGAGCATTGCATGGTTCACTGTCTTTTACTTTGGCAATGGCTGGATTCCTACCCTC
ATCACGGCCTTTGTCCTTGCTACCTCTCAGGCCCAAGCTGGATGGCTGCAACATGATTAT
GGCCACCTGTCTGTCTACAGAAAACCCAAGTGGAACCACCTTGTCCACAAATTCGTCATT
GGCCACTTAAAGGGTGCCTCTGCCAACTGGTGGAATCATCGCCACTTCCAGCACCACGCC
AAGCCTAACATCTTCCACAAGGATCCCGATGTGAACATGCTGCACGTGTTTGTTCTGGGC
GAATGGCAGCCCATCGAGTACGGCAAGAAGAAGCTGAAATACCTGCCCTACAATCACCAG
CACGAATACTTCTTCCTGATTGGGCCGCCGCTGCTCATCCCCATGTATTTCCAGTACCAG
ATCATCATGACCATGATCGTCCATAAGAACTGGGTGGACCTGGCCTGGGCCGTCAGCTAC
TACATCCGGTTCTTCATCACCTACATCCCTTTCTACGGCATCCTGGGAGCCCTCCTTTTC
CTCAACTTCATCAGGTTCCTGGAGAGCCACTGGTTTGTGTGGGTCACACAGATGAATCAC
ATCGTCATGGAGATTGACCAGGAGGCCTACCGTGACTGGTTCAGTAGCCAGCTGACAGCC
ACCTGCAACGTGGAGCAGTCCTTCTTCAACGACTGGTTCAGTGGACACCTTAACTTCCAG
ATTGAGCACCACCTCTTCCCCACCATGCCCCGGCACAACTTACACAAGATCGCCCCGCTG
GTGAAGTCTCTATGTGCCAAGCATGGCATTGAATACCAGGAGAAGCCGCTACTGAGGGCC
CTGCTGGACATCATCAGGTCCCTGAAGAAGTCTGGGAAGCTGTGGCTGGACGCCTACCTT
CACAAATGA
GenBank Gene IDAF126799
GeneCard IDNot Available
GenAtlas IDFADS2
HGNC IDHGNC:3575
Chromosome Location11
Locus11q12-q13.1
References
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  2. Marquardt A, Stohr H, White K, Weber BH: cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000 Jun 1;66(2):175-83. 10860662
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