NameThioredoxin domain-containing protein 12
Synonyms
  • 1.8.4.2
  • Endoplasmic reticulum resident protein 18
  • Endoplasmic reticulum resident protein 19
  • ER protein 18
  • ER protein 19
  • ERp18
  • ERp19
  • hTLP19
  • Thioredoxin-like protein p19
  • TLP19
Gene NameTXNDC12
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019261|Thioredoxin domain-containing protein 12
METRPRLGATCLLGFSFLLLVISSDGHNGLGKGFGDHIHWRTLEDGKKEAAASGLPLMVI
IHKSWCGACKALKPKFAESTEISELSHNFVMVNLEDEEEPKDEDFSPDGGYIPRILFLDP
SGKVHPEIINENGNPSYKYFYVSAEQVVQGMKEAQERLTGDAFRKKHLEDEL
Number of residues172
Molecular Weight19205.615
Theoretical pI5.1
GO Classification
Functions
  • protein-disulfide reductase (glutathione) activity
  • peptide disulfide oxidoreductase activity
Processes
  • cell redox homeostasis
  • negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Components
  • endoplasmic reticulum lumen
General FunctionProtein-disulfide reductase (glutathione) activity
Specific FunctionPossesses significant protein thiol-disulfide oxidase activity.
Pfam Domain FunctionNot Available
Transmembrane RegionsNot Available
GenBank Protein ID23477616
UniProtKB IDO95881
UniProtKB Entry NameTXD12_HUMAN
Cellular LocationEndoplasmic reticulum lumen
Gene sequence
>lcl|BSEQ0019262|Thioredoxin domain-containing protein 12 (TXNDC12)
ATGGAGACGCGGCCTCGTCTCGGGGCCACCTGTTTGCTGGGCTTCAGTTTCCTGCTCCTC
GTCATCTCTTCTGATGGACATAATGGGCTTGGAAAGGGTTTTGGAGATCATATTCATTGG
AGGACACTGGAAGATGGGAAGAAAGAAGCAGCTGCCAGTGGACTGCCCCTGATGGTGATT
ATTCATAAATCCTGGTGTGGAGCTTGCAAAGCTCTAAAGCCCAAATTTGCAGAATCTACG
GAAATTTCAGAACTCTCCCATAATTTTGTTATGGTAAATCTTGAGGATGAAGAGGAACCC
AAAGATGAAGATTTCAGCCCTGACGGGGGTTATATTCCACGAATCCTTTTTCTGGATCCC
AGTGGCAAGGTGCATCCTGAAATCATCAATGAGAATGGAAACCCCAGCTACAAGTATTTT
TATGTCAGTGCCGAGCAAGTTGTTCAGGGGATGAAGGAAGCTCAGGAAAGGCTGACGGGT
GATGCCTTCAGAAAGAAACATCTTGAAGATGAATTGTAA
GenBank Gene IDAF543416
GeneCard IDNot Available
GenAtlas IDTXNDC12
HGNC IDHGNC:24626
Chromosome Location1
Locus1p32.3
References
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