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NameMonocarboxylate transporter 3
Synonyms
  • MCT 3
  • MCT3
  • Solute carrier family 16 member 8
Gene NameSLC16A8
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010110|Monocarboxylate transporter 3
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWV
SSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTG
LGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLL
GGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRR
RLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDI
VARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMV
GALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEV
ALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALE
VLSARGEPTEPEIEARPRLAAESV
Number of residues504
Molecular Weight52318.215
Theoretical pI5.32
GO Classification
Functions
  • symporter activity
  • lactate transmembrane transporter activity
Processes
  • leukocyte migration
  • pyruvate metabolic process
  • lactate transport
  • plasma membrane lactate transport
  • blood coagulation
  • small molecule metabolic process
  • cellular metabolic process
  • transmembrane transport
Components
  • basal plasma membrane
  • membrane
  • plasma membrane
  • integral component of plasma membrane
General FunctionSymporter activity
Specific FunctionProton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate (By similarity).
Pfam Domain Function
Transmembrane Regions15-35 59-79 86-106 116-136 144-164 173-193 255-275 290-310 319-335 343-363 377-397 411-431
GenBank Protein ID6103363
UniProtKB IDO95907
UniProtKB Entry NameMOT3_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010111|Monocarboxylate transporter 3 (SLC16A8)
ATGGGCGCTGGCGGCCCCCGGCGGGGCGAGGGCCCCCCAGACGGCGGCTGGGGCTGGGTG
GTGCTGGGCGCCTGCTTTGTGGTCACCGGCTTCGCCTACGGCTTCCCCAAAGCCGTGAGC
GTCTTCTTCCGCGCGCTCATGCGCGACTTCGACGCCGGCTACAGCGACACGGCCTGGGTG
TCCTCCATCATGCTAGCCATGCTCTACGGCACGGGCCCCGTGTCCAGCATCCTCGTGACC
CGCTTTGGCTGTCGCCCGGTGATGCTGGCGGGTGGGCTGCTGGCTTCCGCGGGCATGATC
CTAGCTTCCTTTGCCACGCGCCTCCTGGAGCTCTACCTGACCGCTGGGGTGCTCACAGGC
CTGGGCCTGGCCCTCAACTTCCAGCCGTCGCTCATCATGCTGGGGCTGTACTTCGAGCGG
CGGCGGCCTCTGGCCAACGGGCTGGCGGCGGCGGGCAGCCCCGTGTTCCTGTCCGCGCTG
TCGCCGCTCGGCCAGCAGCTGCTGGAGCGCTTCGGCTGGCGCGGCGGCTTCCTGCTGCTC
GGCGGGCTCCTGCTGCACTGCTGCGCCTGCGGGGCTGTCATGAGGCCGCCGCCCGGGCCG
GGCCCGCGACCGCGCAGGGACAGCGCCGGCGACCGCGCCGGGGACGCTCCGGGCGAGGCG
GAGGCTGACGGTGCGGGGCTGCAGCTGCGCGAGGCATCCCCCAGGGTCCGGCCCCGCCGG
CGCCTGCTGGACTTGGCAGTGTGCACCGACCGCGCCTTCGCCGTGTACGCCGTCACCAAG
TTCCTGATGGCGCTCGGGCTCTTCGTCCCCGCCATCCTGCTGGTGAACTACGCCAAGGAC
GCGGGCGTGCCCGACACCGACGCCGCCTTCCTGCTGTCCATCGTGGGCTTCGTGGACATC
GTGGCGCGCCCGGCGTGCGGCGCCCTGGCGGGCCTGGCGCGTCTGCGGCCGCACGTCCCG
TATCTGTTCAGCCTGGCCCTGCTGGCCAATGGGCTCACAGACCTGAGCAGCGCACGCGCG
CGCTCCTACGGCGCCCTCGTCGCCTTCTGCGTCGCCTTCGGCCTCTCCTACGGCATGGTG
GGCGCGCTGCAGTTCGAGGTGCTCATGGCGGCTGTGGGCGCGCCCCGCTTCCCCAGTGCG
CTGGGCCTGGTGTTGCTCGTGGAGGCCGCGGCTGTGCTCATCGGACCGCCCTCTGCCGGC
CGCCTGGTGGATGTGTTGAAGAACTATGAGATCATCTTCTACCTGGCCGGCTCTGAGGTG
GCCCTGGCTGGGGTCTTCATGGCTGTCGCCACCAACTGCTGCCTGCGTTGTGCTAAAGCT
GCCCCGTCAGGCCCAGGCACTGAGGGCGGAGCCAGTGACACTGAGGACGCTGAGGCTGAA
GGGGACTCTGAGCCCCTGCCTGTTGTTGCAGAGGAACCCGGCAACCTGGAGGCCCTGGAG
GTGCTCAGCGCCCGGGGCGAGCCCACAGAACCAGAAATAGAGGCGAGGCCGAGGCTGGCT
GCCGAGTCTGTATAA
GenBank Gene IDAF132610
GeneCard IDNot Available
GenAtlas IDSLC16A8
HGNC IDHGNC:16270
Chromosome Location22
Locus22q12.3-q13.2
References
  1. Yoon H, Donoso LA, Philp NJ: Cloning of the human monocarboxylate transporter MCT3 gene: localization to chromosome 22q12.3-q13.2. Genomics. 1999 Sep 15;60(3):366-70. 10493836
  2. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al.: The DNA sequence of human chromosome 22. Nature. 1999 Dec 2;402(6761):489-95. 10591208