L-lactate dehydrogenase A chain

NameL-lactate dehydrogenase A chain
Synonyms
  • 1.1.1.27
  • Cell proliferation-inducing gene 19 protein
  • LDH muscle subunit
  • LDH-A
  • LDH-M
  • Renal carcinoma antigen NY-REN-59
Gene NameLDHA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0037014|L-lactate dehydrogenase A chain
MATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKG
EMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFI
IPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGV
HPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYE
VIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGI
SDLVKVTLTSEEEARLKKSADTLWGIQKELQF
Number of residues332
Molecular Weight36688.465
Theoretical pI8.45
GO Classification
Functions
  • L-lactate dehydrogenase activity
  • NAD binding
Processes
  • positive regulation of apoptotic process
  • response to cAMP
  • response to hydrogen peroxide
  • response to hypoxia
  • pyruvate metabolic process
  • lactate metabolic process
  • NAD metabolic process
  • response to estrogen
  • glycolytic process
  • cellular response to extracellular stimulus
  • response to nutrient
  • response to drug
  • response to glucose
  • substantia nigra development
  • small molecule metabolic process
  • post-embryonic organ development
  • cellular metabolic process
Components
  • mitochondrion
  • membrane
  • nucleus
  • sperm fibrous sheath
  • cytosol
  • extracellular exosome
General FunctionNad binding
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID34313
UniProtKB IDP00338
UniProtKB Entry NameLDHA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0016089|L-lactate dehydrogenase A chain (LDHA)
ATGGCAACTCTAAAGGATCAGCTGATTTATAATCTTCTAAAGGAAGAACAGACCCCCCAG
AATAAGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTA
ATGAAGGACTTGGCAGATGAACTTGCTCTTGTTGATGTCATCGAAGACAAATTGAAGGGA
GAGATGATGGATCTCCAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGC
AAAGTGGATATCTTGACCTACGTGGCTTGGAAGATAAGTGGTTTTCCCAAAAACCGTGTT
ATTGGAAGCGGTTGCAATCTGGATTCAGCCCGATTCCGTTACCTAATGGGGGAAAGGCTG
GGAGTTCACCCATTAAGCTGTCATGGGTGGGTCCTTGGGGAACATGGAGATTCCAGTGTG
CCTGTATGGAGTGGAATGAATGTTGCTGGTGTCTCTCTGAAGACTCTGCACCCAGATTTA
GGGACTGATAAAGATAAGGAACAGTGGAAAGAGGTTCACAAGCAGGTGGTTGAGAGTGCT
TATGAGGTGATCAAACTCAAAGGCTACACATCCTGGGCTATTGGACTCTCTGTAGCAGAT
TTGGCAGAGAGTATAATGAAGAATCTTAGGCGGGTGCACCCAGTTTCCACCATGATTAAG
GGTCTTTACGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGAAT
GGAATCTCAGACCTTGTGAAGGTGACTCTGACTTCTGAGGAAGAGGCCCGTTTGAAGAAG
AGTGCAGATACACTTTGGGGGATCCAAAAGGAGCTGCAATTTTAA
GenBank Gene IDX02152
GeneCard IDNot Available
GenAtlas IDLDHA
HGNC IDHGNC:6535
Chromosome Location11
Locus11p15.4
References
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