Tmic
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NameSuperoxide dismutase [Cu-Zn]
Synonyms
  • 1.15.1.1
  • hSod1
  • Superoxide dismutase 1
Gene NameSOD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021851|Superoxide dismutase [Cu-Zn]
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Number of residues154
Molecular Weight15935.685
Theoretical pI6.07
GO Classification
Functions
  • protein phosphatase 2B binding
  • copper ion binding
  • protein homodimerization activity
  • superoxide dismutase activity
  • chaperone binding
  • Rac GTPase binding
  • identical protein binding
  • zinc ion binding
Processes
  • response to superoxide
  • response to ethanol
  • cellular response to potassium ion
  • locomotory behavior
  • superoxide metabolic process
  • regulation of blood pressure
  • regulation of T cell differentiation in thymus
  • muscle cell cellular homeostasis
  • response to amphetamine
  • transmission of nerve impulse
  • negative regulation of neuron apoptotic process
  • auditory receptor cell stereocilium organization
  • positive regulation of catalytic activity
  • response to nutrient levels
  • response to carbon monoxide
  • platelet activation
  • response to copper ion
  • response to antipsychotic drug
  • thymus development
  • blood coagulation
  • cellular response to ATP
  • superoxide anion generation
  • embryo implantation
  • myeloid cell homeostasis
  • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  • regulation of multicellular organism growth
  • heart contraction
  • glutathione metabolic process
  • neurofilament cytoskeleton organization
  • positive regulation of apoptotic process
  • positive regulation of cytokine production
  • regulation of protein kinase activity
  • retina homeostasis
  • response to heat
  • peripheral nervous system myelin maintenance
  • response to drug
  • response to axon injury
  • cell aging
  • regulation of GTPase activity
  • cellular iron ion homeostasis
  • spermatogenesis
  • response to hydrogen peroxide
  • cellular response to cadmium ion
  • response to antibiotic
  • regulation of mitochondrial membrane potential
  • regulation of organ growth
  • positive regulation of superoxide anion generation
  • response to organic substance
  • sensory perception of sound
  • hydrogen peroxide biosynthetic process
  • activation of MAPK activity
  • retrograde axon cargo transport
  • reactive oxygen species metabolic process
  • response to reactive oxygen species
  • ovarian follicle development
  • platelet degranulation
  • anterograde axon cargo transport
  • removal of superoxide radicals
  • relaxation of vascular smooth muscle
  • negative regulation of cholesterol biosynthetic process
  • placenta development
Components
  • mitochondrial intermembrane space
  • mitochondrion
  • extracellular space
  • cytosol
  • protein complex
  • lysosome
  • extracellular exosome
  • dense core granule
  • extracellular matrix
  • myelin sheath
  • cytoplasmic vesicle
  • nucleoplasm
  • extracellular region
  • nucleus
  • neuronal cell body
  • peroxisome
  • mitochondrial matrix
  • cytoplasm
  • dendrite cytoplasm
General FunctionZinc ion binding
Specific FunctionDestroys radicals which are normally produced within the cells and which are toxic to biological systems.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP00441
UniProtKB Entry NameSODC_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021852|Superoxide dismutase [Cu-Zn] (SOD1)
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA
GenBank Gene IDL44139
GeneCard IDNot Available
GenAtlas IDSOD1
HGNC IDHGNC:11179
Chromosome Location21
LocusNot Available
References
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