Superoxide dismutase [Cu-Zn]

NameSuperoxide dismutase [Cu-Zn]
Synonyms
  • 1.15.1.1
  • hSod1
  • Superoxide dismutase 1
Gene NameSOD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021851|Superoxide dismutase [Cu-Zn]
MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ
Number of residues154
Molecular Weight15935.685
Theoretical pI6.07
GO Classification
Functions
  • protein homodimerization activity
  • Rac GTPase binding
  • identical protein binding
  • protein phosphatase 2B binding
  • zinc ion binding
  • superoxide dismutase activity
  • copper ion binding
  • chaperone binding
Processes
  • response to antibiotic
  • cellular response to potassium ion
  • regulation of mitochondrial membrane potential
  • cell aging
  • muscle cell cellular homeostasis
  • activation of MAPK activity
  • regulation of organ growth
  • removal of superoxide radicals
  • positive regulation of catalytic activity
  • relaxation of vascular smooth muscle
  • positive regulation of apoptotic process
  • retrograde axon cargo transport
  • thymus development
  • response to ethanol
  • negative regulation of cholesterol biosynthetic process
  • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  • regulation of blood pressure
  • response to hydrogen peroxide
  • transmission of nerve impulse
  • positive regulation of cytokine production
  • negative regulation of neuron apoptotic process
  • response to copper ion
  • sensory perception of sound
  • regulation of T cell differentiation in thymus
  • platelet activation
  • peripheral nervous system myelin maintenance
  • embryo implantation
  • platelet degranulation
  • auditory receptor cell stereocilium organization
  • cellular response to cadmium ion
  • glutathione metabolic process
  • response to antipsychotic drug
  • hydrogen peroxide biosynthetic process
  • response to heat
  • locomotory behavior
  • myeloid cell homeostasis
  • regulation of protein kinase activity
  • anterograde axon cargo transport
  • regulation of GTPase activity
  • response to superoxide
  • spermatogenesis
  • response to amphetamine
  • neurofilament cytoskeleton organization
  • superoxide metabolic process
  • response to organic substance
  • retina homeostasis
  • response to nutrient levels
  • reactive oxygen species metabolic process
  • ovarian follicle development
  • blood coagulation
  • cellular iron ion homeostasis
  • cellular response to ATP
  • placenta development
  • response to carbon monoxide
  • positive regulation of superoxide anion generation
  • regulation of multicellular organism growth
  • superoxide anion generation
  • response to reactive oxygen species
  • heart contraction
  • response to drug
  • response to axon injury
Components
  • myelin sheath
  • mitochondrial matrix
  • nucleoplasm
  • extracellular space
  • lysosome
  • cytoplasm
  • cytoplasmic vesicle
  • mitochondrion
  • mitochondrial intermembrane space
  • protein complex
  • peroxisome
  • extracellular matrix
  • dense core granule
  • extracellular region
  • cytosol
  • nucleus
  • neuronal cell body
  • extracellular exosome
  • dendrite cytoplasm
General FunctionZinc ion binding
Specific FunctionDestroys radicals which are normally produced within the cells and which are toxic to biological systems.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP00441
UniProtKB Entry NameSODC_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021852|Superoxide dismutase [Cu-Zn] (SOD1)
ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA
GenBank Gene IDL44139
GeneCard IDNot Available
GenAtlas IDSOD1
HGNC IDHGNC:11179
Chromosome Location21
LocusNot Available
References
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