Hypoxanthine-guanine phosphoribosyltransferase

NameHypoxanthine-guanine phosphoribosyltransferase
Synonyms
  • 2.4.2.8
  • HGPRT
  • HPRT
Gene NameHPRT1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009920|Hypoxanthine-guanine phosphoribosyltransferase
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
Number of residues218
Molecular Weight24579.155
Theoretical pI6.67
GO Classification
Functions
  • guanine phosphoribosyltransferase activity
  • nucleotide binding
  • hypoxanthine phosphoribosyltransferase activity
  • magnesium ion binding
  • protein homodimerization activity
Processes
  • nucleobase-containing small molecule metabolic process
  • positive regulation of dopamine metabolic process
  • central nervous system neuron development
  • protein homotetramerization
  • cerebral cortex neuron differentiation
  • purine nucleobase metabolic process
  • cytolysis
  • purine nucleotide biosynthetic process
  • dendrite morphogenesis
  • purine-containing compound salvage
  • dopamine metabolic process
  • response to amphetamine
  • GMP catabolic process
  • striatum development
  • GMP salvage
  • grooming behavior
  • guanine salvage
  • purine ribonucleoside salvage
  • hypoxanthine metabolic process
  • adenine salvage
  • hypoxanthine salvage
  • IMP metabolic process
  • small molecule metabolic process
  • IMP salvage
  • locomotory behavior
  • lymphocyte proliferation
Components
  • cytoplasm
  • cytosol
  • extracellular exosome
General FunctionProtein homodimerization activity
Specific FunctionConverts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID306885
UniProtKB IDP00492
UniProtKB Entry NameHPRT_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0009921|Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)
ATGGCGACCCGCAGCCCTGGCGTCGTGATTAGTGATGATGAACCAGGTTATGACCTTGAT
TTATTTTGCATACCTAATCATTATGCTGAGGATTTGGAAAGGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACTGAACGTCTTGCTCGAGATGTGATGAAGGAGATGGGAGGCCAT
CACATTGTAGCCCTCTGTGTGCTCAAGGGGGGCTATAAATTCTTTGCTGACCTGCTGGAT
TACATCAAAGCACTGAATAGAAATAGTGATAGATCCATTCCTATGACTGTAGATTTTATC
AGACTGAAGAGCTATTGTAATGACCAGTCAACAGGGGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTGGAAGATATAATTGACACTGGC
AAAACAATGCAGACTTTGCTTTCCTTGGTCAGGCAGTATAATCCAAAGATGGTCAAGGTC
GCAAGCTTGCTGGTGAAAAGGACCCCACGAAGTGTTGGATATAAGCCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTAGGATATGCCCTTGACTATAATGAATACTTCAGG
GATTTGAATCATGTTTGTGTCATTAGTGAAACTGGAAAAGCAAAATACAAAGCCTAA
GenBank Gene IDM31642
GeneCard IDNot Available
GenAtlas IDHPRT1
HGNC IDHGNC:5157
Chromosome LocationX
LocusXq26.1
References
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