Tmic
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NameCarbonic anhydrase 2
Synonyms
  • 4.2.1.1
  • CA-II
  • CAC
  • Carbonate dehydratase II
  • Carbonic anhydrase C
  • Carbonic anhydrase II
Gene NameCA2
OrganismHuman
Amino acid sequence
>lcl|BSEQ0018937|Carbonic anhydrase 2
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
Number of residues260
Molecular Weight29245.895
Theoretical pI7.47
GO Classification
Functions
  • arylesterase activity
  • zinc ion binding
  • carbonate dehydratase activity
Processes
  • positive regulation of osteoclast differentiation
  • positive regulation of cellular pH reduction
  • cellular response to fluid shear stress
  • odontogenesis of dentin-containing tooth
  • positive regulation of bone resorption
  • morphogenesis of an epithelium
  • small molecule metabolic process
  • response to zinc ion
  • secretion
  • bicarbonate transport
  • regulation of chloride transport
  • one-carbon metabolic process
  • regulation of intracellular pH
  • response to pH
  • regulation of anion transport
  • positive regulation of dipeptide transmembrane transport
  • angiotensin-activated signaling pathway
  • positive regulation of synaptic transmission, GABAergic
  • kidney development
  • response to estrogen
Components
  • plasma membrane
  • extracellular space
  • apical part of cell
  • cytosol
  • extracellular exosome
  • myelin sheath
  • basolateral plasma membrane
  • axon
  • cytoplasm
  • microvillus
General FunctionZinc ion binding
Specific FunctionEssential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrate cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye. Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption. Stimulates the chloride-bicarbonate exchange activity of SLC26A6.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID179780
UniProtKB IDP00918
UniProtKB Entry NameCAH2_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0018938|Carbonic anhydrase 2 (CA2)
ATGTCCCATCACTGGGGGTACGGCAAACACAACGGACCTGAGCACTGGCATAAGGACTTC
CCCATTGCCAAGGGAGAGCGCCAGTCCCCTGTTGACATCGACACTCATACAGCCAAGTAT
GACCCTTCCCTGAAGCCCCTGTCTGTTTCCTATGATCAAGCAACTTCCCTGAGGATCCTC
AACAATGGTCATGCTTTCAACGTGGAGTTTGATGACTCTCAGGACAAAGCAGTGCTCAAG
GGAGGACCCCTGGATGGCACTTACAGATTGATTCAGTTTCACTTTCACTGGGGTTCACTT
GATGGACAAGGTTCAGAGCATACTGTGGATAAAAAGAAATATGCTGCAGAACTTCACTTG
GTTCACTGGAACACCAAATATGGGGATTTTGGGAAAGCTGTGCAGCAACCTGATGGACTG
GCCGTTCTAGGTATTTTTTTGAAGGTTGGCAGCGCTAAACCGGGCCTTCAGAAAGTTGTT
GATGTGCTGGATTCCATTAAAACAAAGGGCAAGAGTGCTGACTTCACTAACTTCGATCCT
CGTGGCCTCCTTCCTGAATCCTTGGATTACTGGACCTACCCAGGCTCACTGACCACCCCT
CCTCTTCTGGAATGTGTGACCTGGATTGTGCTCAAGGAACCCATCAGCGTCAGCAGCGAG
CAGGTGTTGAAATTCCGTAAACTTAACTTCAATGGGGAGGGTGAACCCGAAGAACTGATG
GTGGACAACTGGCGCCCAGCTCAGCCACTGAAGAACAGGCAAATCAAAGCTTCCTTCAAA
TAA
GenBank Gene IDM77181
GeneCard IDNot Available
GenAtlas IDCA2
HGNC IDHGNC:1373
Chromosome Location8
Locus8q22
References
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