Argininosuccinate synthase

NameArgininosuccinate synthase
Synonyms
  • 6.3.4.5
  • ASS
  • Citrulline--aspartate ligase
Gene NameASS1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016170|Argininosuccinate synthase
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVF
IEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATG
KGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWS
MDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKD
GTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAF
TMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYI
LGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK
Number of residues412
Molecular Weight46530.055
Theoretical pI8.18
GO Classification
Functions
  • argininosuccinate synthase activity
  • identical protein binding
  • poly(A) RNA binding
  • ATP binding
  • toxic substance binding
  • amino acid binding
Processes
  • liver development
  • arginine biosynthetic process
  • response to nutrient
  • argininosuccinate metabolic process
  • response to zinc ion
  • cellular response to oleic acid
  • aging
  • cellular nitrogen compound metabolic process
  • response to growth hormone
  • cellular response to dexamethasone stimulus
  • small molecule metabolic process
  • cellular response to ammonium ion
  • cellular response to glucagon stimulus
  • cellular response to laminar fluid shear stress
  • citrulline metabolic process
  • urea cycle
  • negative regulation of leukocyte cell-cell adhesion
  • midgut development
  • cellular response to amine stimulus
  • cellular response to amino acid stimulus
  • diaphragm development
  • cellular response to cAMP
  • cellular response to tumor necrosis factor
  • response to estradiol
  • aspartate metabolic process
  • acute-phase response
  • kidney development
  • positive regulation of nitric oxide biosynthetic process
  • polyamine metabolic process
  • cellular response to interferon-gamma
  • cellular response to lipopolysaccharide
  • response to drug
  • response to mycotoxin
Components
  • lysosome
  • mitochondrial outer membrane
  • cytosol
  • extracellular exosome
  • cytoplasm
  • nucleus
  • perikaryon
  • cell body fiber
  • endoplasmic reticulum
General FunctionToxic substance binding
Specific FunctionIs indirectly involved in the control of blood pressure.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID28872
UniProtKB IDP00966
UniProtKB Entry NameASSY_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0016171|Argininosuccinate synthase (ASS1)
ATGTCCAGCAAAGGCTCCGTGGTTCTGGCCTACAGTGGCGGCCTGGACACCTCGTGCATC
CTCGTGTGGCTGAAGGAACAAGGCTATGACGTCATTGCCTATCTGGCCAACATTGGCCAG
AAGGAAGACTTCGAGGAAGCCAGGAAGAAGGCACTGAAGCTTGGGGCCAAAAAGGTGTTC
ATTGAGGATGTCAGCAGGGAGTTTGTGGAGGAGTTCATCTGGCCGGCCATCCAGTCCAGC
GCACTGTATGAGGACCGCTACCTCCTGGGCACCTCTCTTGCCAGGCCCTGCATCGCCCGC
AAACAAGTGGAAATCGCCCAGCGGGAGGGGGCCAAGTATGTGTCCCACGGCGCCACAGGA
AAGGGGAACGATCAGGTCCGGTTTGAGCTCAGCTGCTACTCACTGGCCCCCCAGATAAAG
GTCATTGCTCCCTGGAGGATGCCTGAATTCTACAACCGGTTCAAGGGCCGCAATGACCTG
ATGGAGTACGCAAAGCAACACGGGATTCCCATCCCGGTCACTCCCAAGAACCCGTGGAGC
ATGGATGAGAACCTCATGCACATCAGCTACGAGGCTGGAATCCTGGAGAACCCCAAGAAC
CAAGCGCCTCCAGGTCTCTACACGAAGACCCAGGACCCAGCCAAAGCCCCCAACACCCCT
GACATTCTCGAGATCGAGTTCAAAAAAGGGGTCCCTGTGAAGGTGACCAACGTCAAGGAT
GGCACCACCCACCAGACCTCCTTGGAGCTCTTCATGTACCTGAACGAAGTCGCGGGCAAG
CATGGCGTGGGCCGTATTGACATCGTGGAGAACCGCTTCATTGGAATGAAGTCCCGAGGT
ATCTACGAGACCCCAGCAGGCACCATCCTTTACCATGCTCATTTAGACATCGAGGCCTTC
ACCATGGACCGGGAAGTGCGCAAAATCAAACAAGGCCTGGGCTTGAAATTTGCTGAGCTG
GTGTATACCGGTTTCTGGCACAGCCCTGAGTGTGAATTTGTCCGCCACTGCATCGCCAAG
TCCCAGGAGCGAGTGGAAGGGAAAGTGCAGGTGTCCGTCCTCAAGGGCCAGGTGTACATC
CTCGGCCGGGAGTCCCCACTGTCTCTCTACAATGAGGAGCTGGTGAGCATGAACGTGCAG
GGTGATTATGAGCCAACTGATGCCACCGGGTTCATCAACATCAATTCCCTCAGGCTGAAG
GAATATCATCGTCTCCAGAGCAAGGTCACTGCCAAATAG
GenBank Gene IDX01630
GeneCard IDNot Available
GenAtlas IDASS1
HGNC IDHGNC:758
Chromosome Location9
Locus9q34.1
References
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