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NameMetalloproteinase inhibitor 1
  • CLGI
  • Collagenase inhibitor
  • EPA
  • Erythroid-potentiating activity
  • Fibroblast collagenase inhibitor
  • TIMP
  • TIMP-1
  • Tissue inhibitor of metalloproteinases 1
Gene NameTIMP1
Amino acid sequence
>lcl|BSEQ0019751|Metalloproteinase inhibitor 1
Number of residues207
Molecular Weight23170.64
Theoretical pINot Available
GO Classification
  • metalloendopeptidase inhibitor activity
  • protease binding
  • cytokine activity
  • metal ion binding
  • cartilage development
  • negative regulation of membrane protein ectodomain proteolysis
  • regulation of integrin-mediated signaling pathway
  • negative regulation of metalloenzyme activity
  • extracellular matrix disassembly
  • extracellular matrix organization
  • negative regulation of trophoblast cell migration
  • response to peptide hormone
  • negative regulation of apoptotic process
  • platelet degranulation
  • positive regulation of cell proliferation
  • negative regulation of endopeptidase activity
  • blood coagulation
  • aging
  • response to cytokine
  • response to hormone
  • platelet activation
  • basement membrane
  • extracellular exosome
  • platelet alpha granule lumen
  • extracellular region
  • extracellular space
  • proteinaceous extracellular matrix
General FunctionProtease binding
Specific FunctionMetalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP01033
UniProtKB Entry NameTIMP1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0019752|Metalloproteinase inhibitor 1 (TIMP1)
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
Chromosome LocationX
LocusNot Available
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