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NameIg gamma-1 chain C region
SynonymsNot Available
Gene NameIGHG1
Amino acid sequence
>lcl|BSEQ0005514|Ig gamma-1 chain C region
Number of residues330
Molecular Weight36105.695
Theoretical pI8.31
GO Classification
  • immunoglobulin receptor binding
  • antigen binding
  • phagocytosis, recognition
  • positive regulation of B cell activation
  • complement activation
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • innate immune response
  • Fc-epsilon receptor signaling pathway
  • receptor-mediated endocytosis
  • defense response to bacterium
  • phagocytosis, engulfment
  • B cell receptor signaling pathway
  • complement activation, classical pathway
  • immunoglobulin complex, circulating
  • extracellular region
  • extracellular space
  • extracellular exosome
  • external side of plasma membrane
  • blood microparticle
General FunctionImmunoglobulin receptor binding
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP01857
UniProtKB Entry NameIGHG1_HUMAN
Cellular LocationSecreted
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDIGHG1
Chromosome LocationNot Available
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  3. Rutishauser U, Cunningham BA, Bennett C, Konigsberg WH, Edelman GM: The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7. Biochemistry. 1970 Aug 4;9(16):3171-81. 5530842
  4. Ponstingl H, Hilschmann N: [The rule of antibody structure. The primary structure of a monoclonal IgG1 immunoglobulin (myeloma protein Nie). III. The chymotryptic peptides of the H-chain, alignment of the tryptic peptides and discussion of the complete structure]. Hoppe Seylers Z Physiol Chem. 1976 Nov;357(11):1571-604. 826475
  5. Schmidt WE, Jung HD, Palm W, Hilschmann N: [Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I]. Hoppe Seylers Z Physiol Chem. 1983 Jun;364(6):713-47. 6884994
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