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NameIg alpha-1 chain C region
SynonymsNot Available
Gene NameIGHA1
Amino acid sequence
>lcl|BSEQ0008861|Ig alpha-1 chain C region
Number of residues353
Molecular Weight37654.29
Theoretical pINot Available
GO Classification
  • antigen binding
  • phagocytosis, engulfment
  • retina homeostasis
  • B cell receptor signaling pathway
  • antibacterial humoral response
  • complement activation, classical pathway
  • phagocytosis, recognition
  • immune response
  • positive regulation of B cell activation
  • protein-chromophore linkage
  • glomerular filtration
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • innate immune response
  • positive regulation of respiratory burst
  • Fc-epsilon receptor signaling pathway
  • receptor-mediated endocytosis
  • blood microparticle
  • extracellular region
  • extracellular space
  • extracellular exosome
  • monomeric IgA immunoglobulin complex
  • secretory dimeric IgA immunoglobulin complex
  • secretory IgA immunoglobulin complex
  • external side of plasma membrane
General FunctionAntigen binding
Specific FunctionIg alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP01876
UniProtKB Entry NameIGHA1_HUMAN
Cellular LocationNot Available
Gene sequenceNot Available
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
Chromosome LocationNot Available
LocusNot Available
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  2. Putnam FW, Liu YS, Low TL: Primary structure of a human IgA1 immunoglobulin. IV. Streptococcal IgA1 protease, digestion, Fab and Fc fragments, and the complete amino acid sequence of the alpha 1 heavy chain. J Biol Chem. 1979 Apr 25;254(8):2865-74. 107164
  3. Kratzin H, Altevogt P, Ruban E, Kortt A, Staroscik K, Hilschmann N: [The primary structure of a monoclonal IgA-immunoglobulin (IgA Tro.), II. The amino acid sequence of the H-chain, alpha-type, subgroup III; structure of the complete IgA-molecule (author's transl)]. Hoppe Seylers Z Physiol Chem. 1975 Aug;356(8):1337-42. 809331
  4. Yang C, Kratzin H, Gotz H, Hilschmann N: [Rule of antibody structure. Primary structure of a human monoclonal IgA-immunoglobulin (myeloma protein Tro). VII. Purification and characterization of the disulfide bridges]. Hoppe Seylers Z Physiol Chem. 1979 Dec;360(12):1919-40. 393607
  5. Calero M, Escribano J, Grubb A, Mendez E: Location of a novel type of interpolypeptide chain linkage in the human protein HC-IgA complex (HC-IgA) and identification of a heterogeneous chromophore associated with the complex. J Biol Chem. 1994 Jan 7;269(1):384-9. 7506257
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