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NameC-X-C motif chemokine 10
  • 10 kDa interferon gamma-induced protein
  • Gamma-IP10
  • INP10
  • IP-10
  • SCYB10
  • Small-inducible cytokine B10
Gene NameCXCL10
Amino acid sequence
>lcl|BSEQ0016256|C-X-C motif chemokine 10
Number of residues98
Molecular Weight10880.915
Theoretical pI10.62
GO Classification
  • CXCR3 chemokine receptor binding
  • receptor binding
  • chemokine activity
  • heparin binding
  • cAMP-dependent protein kinase regulator activity
  • signal transduction
  • cell surface receptor signaling pathway
  • positive regulation of cAMP metabolic process
  • positive regulation of cell proliferation
  • positive regulation of leukocyte chemotaxis
  • positive regulation of release of sequestered calcium ion into cytosol
  • immune response
  • response to auditory stimulus
  • cellular response to lipopolysaccharide
  • endothelial cell activation
  • positive regulation of monocyte chemotaxis
  • negative regulation of myoblast differentiation
  • inflammatory response
  • negative regulation of myoblast fusion
  • positive regulation of cAMP-mediated signaling
  • cell-cell signaling
  • regulation of endothelial tube morphogenesis
  • response to cold
  • chemotaxis
  • regulation of T cell chemotaxis
  • response to vitamin D
  • T cell chemotaxis
  • muscle organ development
  • positive regulation of T cell migration
  • regulation of protein kinase activity
  • response to gamma radiation
  • regulation of cell proliferation
  • chemokine-mediated signaling pathway
  • cellular response to heat
  • positive regulation of transcription from RNA polymerase II promoter
  • defense response to virus
  • blood circulation
  • negative regulation of angiogenesis
  • G-protein coupled receptor signaling pathway
  • extracellular region
  • extracellular space
  • external side of plasma membrane
General FunctionReceptor binding
Specific FunctionChemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID33918
UniProtKB IDP02778
UniProtKB Entry NameCXL10_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0016257|C-X-C motif chemokine 10 (CXCL10)
GenBank Gene IDX02530
GeneCard IDNot Available
GenAtlas IDCXCL10
Chromosome Location4
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  3. Proost P, De Wolf-Peeters C, Conings R, Opdenakker G, Billiau A, Van Damme J: Identification of a novel granulocyte chemotactic protein (GCP-2) from human tumor cells. In vitro and in vivo comparison with natural forms of GRO, IP-10, and IL-8. J Immunol. 1993 Feb 1;150(3):1000-10. 8423327
  4. Tensen CP, Flier J, Van Der Raaij-Helmer EM, Sampat-Sardjoepersad S, Van Der Schors RC, Leurs R, Scheper RJ, Boorsma DM, Willemze R: Human IP-9: A keratinocyte-derived high affinity CXC-chemokine ligand for the IP-10/Mig receptor (CXCR3). J Invest Dermatol. 1999 May;112(5):716-22. 10233762
  5. Hensbergen PJ, van der Raaij-Helmer EM, Dijkman R, van der Schors RC, Werner-Felmayer G, Boorsma DM, Scheper RJ, Willemze R, Tensen CP: Processing of natural and recombinant CXCR3-targeting chemokines and implications for biological activity. Eur J Biochem. 2001 Sep;268(18):4992-9. 11559369
  6. Loos T, Mortier A, Gouwy M, Ronsse I, Put W, Lenaerts JP, Van Damme J, Proost P: Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation. Blood. 2008 Oct 1;112(7):2648-56. doi: 10.1182/blood-2008-04-149039. Epub 2008 Jul 21. 18645041
  7. Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD: The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 2002 Aug 20;41(33):10418-25. 12173928