NameFerritin light chain
Synonyms
  • Ferritin L subunit
Gene NameFTL
OrganismHuman
Amino acid sequence
>lcl|BSEQ0036948|Ferritin light chain
MSSQIRQNYSTDVEAAVNSLVNLYLQASYTYLSLGFYFDRDDVALEGVSHFFRELAEEKR
EGYERLLKMQNQRGGRALFQDIKKPAEDEWGKTPDAMKAAMALEKKLNQALLDLHALGSA
RTDPHLCDFLETHFLDEEVKLIKKMGDHLTNLHRLGGPEAGLGEYLFERLTLKHD
Number of residues175
Molecular Weight20019.49
Theoretical pI5.59
GO Classification
Functions
  • iron ion binding
  • ferric iron binding
  • identical protein binding
Processes
  • membrane organization
  • cellular iron ion homeostasis
  • post-Golgi vesicle-mediated transport
  • iron ion homeostasis
  • iron ion transport
  • transmembrane transport
  • receptor-mediated endocytosis
Components
  • intracellular ferritin complex
  • membrane
  • cytosol
  • extracellular exosome
General FunctionIron ion binding
Specific FunctionStores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID182514
UniProtKB IDP02792
UniProtKB Entry NameFRIL_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0016009|Ferritin light chain (FTL)
ATGAGCTCCCAGATTCGTCAGAATTATTCCACCGACGTGGAGGCAGCCGTCAACAGCCTG
GTCAATTTGTACCTGCAGGCCTCCTACACCTACCTCTCTCTGGGCTTCTATTTCGACCGC
GATGATGTGGCTCTGGAAGGCGTGAGCCACTTCTTCCGCGAATTGGCCGAGGAGAAGCGC
GAGGGCTACGAGCGTCTCCTGAAGATGCAAAACCAGCGTGGCGGCCGCGCTCTCTTCCAG
GACATCAAGAAGCCAGCTGAAGATGAGTGGGGTAAAACCCCAGACGCCATGAAAGCTGCC
ATGGCCCTGGAGAAAAAGCTGAACCAGGCCCTTTTGGATCTTCATGCCCTGGGTTCTGCC
CGCACGGACCCCCATCTCTGTGACTTCCTGGAGACTCACTTCCTAGATGAGGAAGTGAAG
CTTATCAAGAAGATGGGTGACCACCTGACCAACCTCCACAGGCTGGGTGGCCCGGAGGCT
GGGCTGGGCGAGTATCTCTTCGAAAGGCTCACTCTCAAGCACGACTAA
GenBank Gene IDM11147
GeneCard IDNot Available
GenAtlas IDFTL
HGNC IDHGNC:3999
Chromosome Location19
Locus19q13.3-q13.4
References
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