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NameOsteocalcin
Synonyms
  • BGP
  • Bone Gla protein
  • Gamma-carboxyglutamic acid-containing protein
Gene NameBGLAP
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020481|Osteocalcin
MRALTLLALLALAALCIAGQAGAKPSGAESSKGAAFVSKQEGSEVVKRPRRYLYQWLGAP
VPYPDPLEPRREVCELNPDCDELADHIGFQEAYRRFYGPV
Number of residues100
Molecular Weight10962.445
Theoretical pI7.18
GO Classification
Functions
  • structural constituent of bone
  • hydroxyapatite binding
  • structural molecule activity
  • calcium ion binding
Processes
  • response to drug
  • cellular response to growth factor stimulus
  • regulation of bone mineralization
  • response to vitamin D
  • osteoblast development
  • osteoblast differentiation
  • response to testosterone
  • skeletal system development
  • odontogenesis
  • regulation of bone resorption
  • response to gravity
  • response to activity
  • regulation of osteoclast differentiation
  • response to estrogen
  • cell aging
  • response to glucocorticoid
  • bone development
  • response to vitamin K
  • response to mechanical stimulus
  • cell adhesion
  • response to ethanol
  • cellular response to vitamin D
  • response to zinc ion
  • response to hydroxyisoflavone
  • bone mineralization
Components
  • rough endoplasmic reticulum
  • extracellular space
  • Golgi apparatus
  • dendrite
  • perikaryon
  • membrane-bounded vesicle
  • cytoplasm
General FunctionStructural molecule activity
Specific FunctionConstitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID36093
UniProtKB IDP02818
UniProtKB Entry NameOSTCN_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0020482|Osteocalcin (BGLAP)
ATGAGAGCCCTCACACTCCTCGCCCTATTGGCCCTGGCCGCACTTTGCATCGCTGGCCAG
GCAGGTGCGAAGCCCAGCGGTGCAGAGTCCAGCAAAGGTGCAGCCTTTGTGTCCAAGCAG
GAGGGCAGCGAGGTAGTGAAGAGACCCAGGCGCTACCTGTATCAATGGCTGGGAGCCCCA
GTCCCCTACCCGGATCCCCTGGAGCCCAGGAGGGAGGTGTGTGAGCTCAATCCGGACTGT
GACGAGTTGGCTGACCACATCGGCTTTCAGGAGGCCTATCGGCGCTTCTACGGCCCGGTC
TAG
GenBank Gene IDX53698
GeneCard IDNot Available
GenAtlas IDBGLAP
HGNC IDHGNC:1043
Chromosome Location1
Locus1q25-q31
References
  1. Kiefer MC, Saphire AC, Bauer DM, Barr PJ: The cDNA and derived amino acid sequences of human and bovine bone Gla protein. Nucleic Acids Res. 1990 Apr 11;18(7):1909. 2336375
  2. Celeste AJ, Rosen V, Buecker JL, Kriz R, Wang EA, Wozney JM: Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones. EMBO J. 1986 Aug;5(8):1885-90. 3019668
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  5. Poser JW, Esch FS, Ling NC, Price PA: Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue. J Biol Chem. 1980 Sep 25;255(18):8685-91. 6967872