Tmic
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NameEstrogen receptor
Synonyms
  • ER
  • ER-alpha
  • ESR
  • Estradiol receptor
  • NR3A1
  • Nuclear receptor subfamily 3 group A member 1
Gene NameESR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000246|Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Number of residues595
Molecular Weight66215.45
Theoretical pI8.14
GO Classification
Functions
  • transcription factor activity, sequence-specific DNA binding
  • steroid hormone receptor activity
  • estrogen receptor activity
  • estrogen response element binding
  • ATPase binding
  • steroid binding
  • RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
  • chromatin binding
  • nitric-oxide synthase regulator activity
  • transcription factor binding
  • enzyme binding
  • identical protein binding
  • zinc ion binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • beta-catenin binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • core promoter sequence-specific DNA binding
Processes
  • intracellular estrogen receptor signaling pathway
  • positive regulation of transcription from RNA polymerase II promoter
  • signal transduction
  • gene expression
  • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
  • antral ovarian follicle growth
  • phospholipase C-activating G-protein coupled receptor signaling pathway
  • negative regulation of sequence-specific DNA binding transcription factor activity
  • regulation of apoptotic process
  • prostate epithelial cord elongation
  • response to estrogen
  • uterus development
  • transcription initiation from RNA polymerase II promoter
  • mammary gland branching involved in pregnancy
  • epithelial cell development
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • mammary gland alveolus development
  • vagina development
  • positive regulation of sequence-specific DNA binding transcription factor activity
  • positive regulation of nitric-oxide synthase activity
  • androgen metabolic process
  • positive regulation of cytosolic calcium ion concentration
  • positive regulation of phospholipase C activity
  • regulation of branching involved in prostate gland morphogenesis
  • regulation of transcription, DNA-templated
  • positive regulation of fibroblast proliferation
  • epithelial cell proliferation involved in mammary gland duct elongation
  • transcription, DNA-templated
  • cellular response to estradiol stimulus
  • chromatin remodeling
  • intracellular steroid hormone receptor signaling pathway
  • male gonad development
  • transcription from RNA polymerase II promoter
  • positive regulation of transcription, DNA-templated
  • negative regulation of gene expression
  • response to estradiol
  • positive regulation of nitric oxide biosynthetic process
Components
  • nucleus
  • cytosol
  • plasma membrane
  • nucleoplasm
  • transcriptionally active chromatin
  • cytoplasm
  • Golgi apparatus
  • membrane
  • nuclear chromatin
  • integral component of membrane
General FunctionZinc ion binding
Specific FunctionNuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31234
UniProtKB IDP03372
UniProtKB Entry NameESR1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021831|Estrogen receptor (ESR1)
ATGACCATGACCCTCCACACCAAAGCATCTGGGATGGCCCTACTGCATCAGATCCAAGGG
AACGAGCTGGAGCCCCTGAACCGTCCGCAGCTCAAGATCCCCCTGGAGCGGCCCCTGGGC
GAGGTGTACCTGGACAGCAGCAAGCCCGCCGTGTACAACTACCCCGAGGGCGCCGCCTAC
GAGTTCAACGCCGCGGCCGCCGCCAACGCGCAGGTCTACGGTCAGACCGGCCTCCCCTAC
GGCCCCGGGTCTGAGGCTGCGGCGTTCGGCTCCAACGGCCTGGGGGGTTTCCCCCCACTC
AACAGCGTGTCTCCGAGCCCGCTGATGCTACTGCACCCGCCGCCGCAGCTGTCGCCTTTC
CTGCAGCCCCACGGCCAGCAGGTGCCCTACTACCTGGAGAACGAGCCCAGCGGCTACACG
GTGCGCGAGGCCGGCCCGCCGGCATTCTACAGGCCAAATTCAGATAATCGACGCCAGGGT
GGCAGAGAAAGATTGGCCAGTACCAATGACAAGGGAAGTATGGCTATGGAATCTGCCAAG
GAGACTCGCTACTGTGCAGTGTGCAATGACTATGCTTCAGGCTACCATTATGGAGTCTGG
TCCTGTGAGGGCTGCAAGGCCTTCTTCAAGAGAAGTATTCAAGGACATAACGACTATATG
TGTCCAGCCACCAACCAGTGCACCATTGATAAAAACAGGAGGAAGAGCTGCCAGGCCTGC
CGGCTCCGCAAATGCTACGAAGTGGGAATGATGAAAGGTGGGATACGAAAAGACCGAAGA
GGAGGGAGAATGTTGAAACACAAGCGCCAGAGAGATGATGGGGAGGGCAGGGGTGAAGTG
GGGTCTGCTGGAGACATGAGAGCTGCCAACCTTTGGCCAAGCCCGCTCATGATCAAACGC
TCTAAGAAGAACAGCCTGGCCTTGTCCCTGACGGCCGACCAGATGGTCAGTGCCTTGTTG
GATGCTGAGCCCCCCATACTCTATTCCGAGTATGATCCTACCAGACCCTTCAGTGAAGCT
TCGATGATGGGCTTACTGACCAACCTGGCAGACAGGGAGCTGGTTCACATGATCAACTGG
GCGAAGAGGGTGCCAGGCTTTGTGGATTTGACCCTCCATGATCAGGTCCACCTTCTAGAA
TGTGCCTGGCTAGAGATCCTGATGATTGGTCTCGTCTGGCGCTCCATGGAGCACCCAGGG
AAGCTACTGTTTGCTCCTAACTTGCTCTTGGACAGGAACCAGGGAAAATGTGTAGAGGGC
ATGGTGGAGATCTTCGACATGCTGCTGGCTACATCATCTCGGTTCCGCATGATGAATCTG
CAGGGAGAGGAGTTTGTGTGCCTCAAATCTATTATTTTGCTTAATTCTGGAGTGTACACA
TTTCTGTCCAGCACCCTGAAGTCTCTGGAAGAGAAGGACCATATCCACCGAGTCCTGGAC
AAGATCACAGACACTTTGATCCACCTGATGGCCAAGGCAGGCCTGACCCTGCAGCAGCAG
CACCAGCGGCTGGCCCAGCTCCTCCTCATCCTCTCCCACATCAGGCACATGAGTAACAAA
GGCATGGAGCATCTGTACAGCATGAAGTGCAAGAACGTGGTGCCCCTCTATGACCTGCTG
CTGGAGATGCTGGACGCCCACCGCCTACATGCGCCCACTAGCCGTGGAGGGGCATCCGTG
GAGGAGACGGACCAAAGCCACTTGGCCACTGCGGGCTCTACTTCATCGCATTCCTTGCAA
AAGTATTACATCACGGGGGAGGCAGAGGGTTTCCCTGCCACGGTCTGA
GenBank Gene IDX03635
GeneCard IDNot Available
GenAtlas IDESR1
HGNC IDHGNC:3467
Chromosome Location6
Locus6q25.1
References
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