Tmic
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NameCatalase
Synonyms
  • 1.11.1.6
Gene NameCAT
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020512|Catalase
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
Number of residues527
Molecular Weight59755.82
Theoretical pI7.41
GO Classification
Functions
  • antioxidant activity
  • enzyme binding
  • receptor binding
  • catalase activity
  • aminoacylase activity
  • protein homodimerization activity
  • NADP binding
  • heme binding
  • oxidoreductase activity, acting on peroxide as acceptor
  • metal ion binding
Processes
  • response to L-ascorbic acid
  • response to hydrogen peroxide
  • protein homotetramerization
  • aerobic respiration
  • response to cadmium ion
  • response to ozone
  • response to hyperoxia
  • purine nucleobase metabolic process
  • response to vitamin A
  • UV protection
  • response to activity
  • response to vitamin E
  • response to light intensity
  • response to drug
  • positive regulation of cell division
  • negative regulation of NF-kappaB transcription factor activity
  • protein tetramerization
  • response to toxic substance
  • small molecule metabolic process
  • response to fatty acid
  • hemoglobin metabolic process
  • negative regulation of apoptotic process
  • cholesterol metabolic process
  • hydrogen peroxide catabolic process
  • response to phenylpropanoid
  • response to hypoxia
  • response to insulin
  • response to lead ion
  • triglyceride metabolic process
  • positive regulation of phosphatidylinositol 3-kinase signaling
  • cellular response to growth factor stimulus
  • positive regulation of NF-kappaB transcription factor activity
  • response to inactivity
  • purine nucleotide catabolic process
  • osteoblast differentiation
  • ureteric bud development
  • response to reactive oxygen species
  • response to ethanol
  • response to estradiol
  • nucleobase-containing small molecule metabolic process
  • aging
Components
  • membrane
  • intracellular membrane-bounded organelle
  • endoplasmic reticulum
  • peroxisome
  • peroxisomal membrane
  • peroxisomal matrix
  • Golgi apparatus
  • plasma membrane
  • cytosol
  • extracellular exosome
  • focal adhesion
  • extracellular space
  • mitochondrial intermembrane space
  • lysosome
  • mitochondrion
General FunctionReceptor binding
Specific FunctionOccurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID1228085
UniProtKB IDP04040
UniProtKB Entry NameCATA_HUMAN
Cellular LocationPeroxisome
Gene sequence
>lcl|BSEQ0020513|Catalase (CAT)
ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAGAAAGCTGATGTCCTGACCACTGGAGCTGGTAACCCAGTAGGAGACAAACTTAAT
GTTATTACAGTAGGGCCCCGTGGGCCCCTTCTTGTTCAGGATGTGGTTTTCACTGATGAA
ATGGCTCATTTTGACCGAGAGAGAATTCCTGAGAGAGTTGTGCATGCTAAAGGAGCAGGG
GCCTTTGGCTACTTTGAGGTCACACATGACATTACCAAATACTCCAAGGCAAAGGTATTT
GAGCATATTGGAAAGAAGACTCCCATCGCAGTTCGGTTCTCCACTGTTGCTGGAGAATCG
GGTTCAGCTGACACAGTTCGGGACCCTCGTGGGTTTGCAGTGAAATTTTACACAGAAGAT
GGTAACTGGGATCTCGTTGGAAATAACACCCCCATTTTCTTCATCAGGGATCCCATATTG
TTTCCATCTTTTATCCACAGCCAAAAGAGAAATCCTCAGACACATCTGAAGGATCCGGAC
ATGGTCTGGGACTTCTGGAGCCTACGTCCTGAGTCTCTGCATCAGGTTTCTTTCTTGTTC
AGTGATCGGGGGATTCCAGATGGACATCGCCACATGAATGGATATGGATCACATACTTTC
AAGCTGGTTAATGCAAATGGGGAGGCAGTTTATTGCAAATTCCATTATAAGACTGACCAG
GGCATCAAAAACCTTTCTGTTGAAGATGCGGCGAGACTTTCCCAGGAAGATCCTGACTAT
GGCATCCGGGATCTTTTTAACGCCATTGCCACAGGAAAGTACCCCTCCTGGACTTTTTAC
ATCCAGGTCATGACATTTAATCAGGCAGAAACTTTTCCATTTAATCCATTCGATCTCACC
AAGGTTTGGCCTCACAAGGACTACCCTCTCATCCCAGTTGGTAAACTGGTCTTAAACCGG
AATCCAGTTAATTACTTTGCTGAGGTTGAACAGATAGCCTTCGACCCAAGCAACATGCCA
CCTGGCATTGAGGCCAGTCCTGACAAAATGCTTCAGGGCCGCCTTTTTGCCTATCCTGAC
ACTCACCGCCATCGCCTGGGACCCAATTATCTTCATATACCTGTGAACTGTCCCTACCGT
GCTCGAGTGGCCAACTACCAGCGTGACGGCCCGATGTGCATGCAGGACAATCAGGGTGGT
GCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAG
CACAGCATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTT
ACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGT
GAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAG
AACTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTAC
AATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCG
GCAAGGGAGAAGGCAAATCTGTGA
GenBank Gene IDX04085
GeneCard IDNot Available
GenAtlas IDCAT
HGNC IDHGNC:1516
Chromosome Location11
Locus11p13
References
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