NamePhospholipase A2
Synonyms
  • 3.1.1.4
  • Group IB phospholipase A2
  • Phosphatidylcholine 2-acylhydrolase 1B
  • PLA2
  • PLA2A
  • PPLA2
Gene NamePLA2G1B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019511|Phospholipase A2
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPV
DELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNC
DRNAAICFSKAPYNKAHKNLDTKKYCQS
Number of residues148
Molecular Weight16359.535
Theoretical pI7.91
GO Classification
Functions
  • phospholipase A2 activity
  • receptor binding
  • bile acid binding
  • calcium-dependent phospholipase A2 activity
  • calcium ion binding
Processes
  • glycerophospholipid biosynthetic process
  • innate immune response in mucosa
  • phospholipid metabolic process
  • positive regulation of fibroblast proliferation
  • phosphatidic acid biosynthetic process
  • activation of phospholipase A2 activity
  • phosphatidylcholine acyl-chain remodeling
  • actin filament organization
  • phosphatidylethanolamine acyl-chain remodeling
  • positive regulation of calcium ion transport into cytosol
  • phosphatidylglycerol acyl-chain remodeling
  • small molecule metabolic process
  • phosphatidylcholine metabolic process
  • phosphatidylinositol acyl-chain remodeling
  • neutrophil mediated immunity
  • phosphatidylserine acyl-chain remodeling
  • leukotriene biosynthetic process
  • interleukin-8 production
  • arachidonic acid secretion
  • multicellular organismal lipid catabolic process
  • positive regulation of immune response
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of protein secretion
  • neutrophil chemotaxis
  • glucose transport
  • intracellular signal transduction
  • cellular response to insulin stimulus
  • positive regulation of NF-kappaB transcription factor activity
  • positive regulation of DNA replication
  • activation of MAPK activity
  • signal transduction
  • antibacterial humoral response
  • fatty acid biosynthetic process
  • defense response to Gram-positive bacterium
Components
  • extracellular region
  • extracellular space
  • cell surface
  • secretory granule
General FunctionReceptor binding
Specific FunctionPA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID190013
UniProtKB IDP04054
UniProtKB Entry NamePA21B_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0019512|Phospholipase A2 (PLA2G1B)
ATGAAACTCCTTGTGCTAGCTGTGCTGCTCACAGTGGCCGCCGCCGACAGCGGCATCAGC
CCTCGGGCCGTGTGGCAGTTCCGCAAAATGATCAAGTGCGTGATCCCGGGGAGTGACCCC
TTCTTGGAATACAACAACTACGGCTGCTACTGTGGCTTGGGGGGCTCAGGCACCCCCGTG
GATGAACTGGACAAGTGCTGCCAGACACATGACAACTGCTATGACCAGGCCAAGAAGCTG
GACAGCTGTAAATTTCTGCTGGACAACCCGTACACCCACACCTATTCATACTCGTGCTCT
GGCTCGGCAATCACCTGTAGCAGCAAAAACAAAGAGTGTGAGGCCTTCATTTGCAACTGC
GACCGCAACGCTGCCATCTGCTTTTCAAAAGCTCCATATAACAAGGCACACAAGAACCTG
GACACCAAGAAGTATTGTCAGAGTTGA
GenBank Gene IDM21054
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:9030
Chromosome Location12
Locus12q23-q24.1
References
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