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NameProtein S100-B
  • S-100 protein beta chain
  • S-100 protein subunit beta
  • S100 calcium-binding protein B
Gene NameS100B
Amino acid sequence
>lcl|BSEQ0010821|Protein S100-B
Number of residues92
Molecular Weight10712.985
Theoretical pI4.25
GO Classification
  • protein homodimerization activity
  • calcium-dependent protein binding
  • S100 protein binding
  • RAGE receptor binding
  • identical protein binding
  • tau protein binding
  • zinc ion binding
  • calcium ion binding
  • cell proliferation
  • long-term synaptic potentiation
  • positive regulation of I-kappaB kinase/NF-kappaB signaling
  • innate immune response
  • positive regulation of apoptotic process
  • astrocyte differentiation
  • positive regulation of cell proliferation
  • negative regulation of skeletal muscle cell differentiation
  • response to glucocorticoid
  • regulation of neuronal synaptic plasticity
  • axonogenesis
  • cellular response to hypoxia
  • memory
  • response to methylmercury
  • central nervous system development
  • regulation of cell shape
  • learning or memory
  • perinuclear region of cytoplasm
  • ruffle
  • intracellular membrane-bounded organelle
  • cytoplasm
  • neuronal cell body
  • extracellular region
  • nucleus
  • extracellular space
General FunctionZinc ion binding
Specific FunctionWeakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID337730
UniProtKB IDP04271
UniProtKB Entry NameS100B_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010822|Protein S100-B (S100B)
GenBank Gene IDM59488
GeneCard IDNot Available
GenAtlas IDS100B
Chromosome Location21
LocusNot Available
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  4. Jensen R, Marshak DR, Anderson C, Lukas TJ, Watterson DM: Characterization of human brain S100 protein fraction: amino acid sequence of S100 beta. J Neurochem. 1985 Sep;45(3):700-5. 4031854
  5. Baudier J, Glasser N, Haglid K, Gerard D: Purification, characterization and ion binding properties of human brain S100b protein. Biochim Biophys Acta. 1984 Oct 23;790(2):164-73. 6487634
  6. Yang Q, O'Hanlon D, Heizmann CW, Marks A: Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma. Exp Cell Res. 1999 Feb 1;246(2):501-9. 9925766
  7. Park H, Adsit FG, Boyington JC: The 1.5 A crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding. J Biol Chem. 2010 Dec 24;285(52):40762-70. doi: 10.1074/jbc.M110.169276. Epub 2010 Oct 13. 20943659
  8. Gilquin B, Cannon BR, Hubstenberger A, Moulouel B, Falk E, Merle N, Assard N, Kieffer S, Rousseau D, Wilder PT, Weber DJ, Baudier J: The calcium-dependent interaction between S100B and the mitochondrial AAA ATPase ATAD3A and the role of this complex in the cytoplasmic processing of ATAD3A. Mol Cell Biol. 2010 Jun;30(11):2724-36. doi: 10.1128/MCB.01468-09. Epub 2010 Mar 29. 20351179
  9. Yamaguchi F, Umeda Y, Shimamoto S, Tsuchiya M, Tokumitsu H, Tokuda M, Kobayashi R: S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation. J Biol Chem. 2012 Apr 20;287(17):13787-98. doi: 10.1074/jbc.M111.329771. Epub 2012 Mar 7. 22399290
  10. Smith SP, Shaw GS: A novel calcium-sensitive switch revealed by the structure of human S100B in the calcium-bound form. Structure. 1998 Feb 15;6(2):211-22. 9519411
  11. McClintock KA, Shaw GS: A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. J Biol Chem. 2003 Feb 21;278(8):6251-7. Epub 2002 Dec 11. 12480931