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NameCellular tumor antigen p53
Synonyms
  • Antigen NY-CO-13
  • P53
  • Phosphoprotein p53
  • Tumor suppressor p53
Gene NameTP53
OrganismHuman
Amino acid sequence
>lcl|BSEQ0006595|Cellular tumor antigen p53
MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGP
DEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAK
SVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHE
RCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNS
SCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELP
PGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPG
GSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD
Number of residues393
Molecular Weight43652.79
Theoretical pI6.78
GO Classification
Functions
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • enzyme binding
  • protein heterodimerization activity
  • transcription factor activity, sequence-specific DNA binding
  • damaged DNA binding
  • ATP binding
  • protein self-association
  • protein N-terminus binding
  • protein kinase binding
  • RNA polymerase II transcription factor binding
  • copper ion binding
  • ubiquitin protein ligase binding
  • protein phosphatase 2A binding
  • identical protein binding
  • sequence-specific DNA binding
  • histone acetyltransferase binding
  • DNA binding
  • protein phosphatase binding
  • core promoter sequence-specific DNA binding
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
  • RNA polymerase II core promoter sequence-specific DNA binding
  • double-stranded DNA binding
  • transcription regulatory region DNA binding
  • histone deacetylase regulator activity
  • protease binding
  • chromatin binding
  • receptor tyrosine kinase binding
  • transcription factor binding
  • p53 binding
  • chaperone binding
  • zinc ion binding
Processes
  • cellular response to DNA damage stimulus
  • intrinsic apoptotic signaling pathway
  • release of cytochrome c from mitochondria
  • mitotic cell cycle arrest
  • nucleotide-excision repair
  • positive regulation of reactive oxygen species metabolic process
  • entrainment of circadian clock by photoperiod
  • negative regulation of neuroblast proliferation
  • oxidative stress-induced premature senescence
  • double-strand break repair
  • cellular response to ionizing radiation
  • DNA damage response, signal transduction by p53 class mediator
  • positive regulation of cardiac muscle cell apoptotic process
  • determination of adult lifespan
  • cellular response to UV-C
  • positive regulation of apoptotic process
  • rRNA transcription
  • positive regulation of cell cycle arrest
  • negative regulation of transcription from RNA polymerase II promoter
  • response to gamma radiation
  • somitogenesis
  • circadian behavior
  • positive regulation of peptidyl-tyrosine phosphorylation
  • chromatin assembly
  • cell proliferation
  • response to ischemia
  • DNA strand renaturation
  • regulation of transcription, DNA-templated
  • Notch signaling pathway
  • cellular protein localization
  • negative regulation of glucose catabolic process to lactate via pyruvate
  • base-excision repair
  • gastrulation
  • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • blood coagulation
  • intrinsic apoptotic signaling pathway in response to hypoxia
  • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  • replicative senescence
  • negative regulation of macromitophagy
  • embryonic organ development
  • negative regulation of helicase activity
  • positive regulation of transcription, DNA-templated
  • chromosome breakage
  • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • protein complex assembly
  • negative regulation of fibroblast proliferation
  • positive regulation of neuron apoptotic process
  • negative regulation of reactive oxygen species metabolic process
  • oligodendrocyte apoptotic process
  • multicellular organism growth
  • positive regulation of release of cytochrome c from mitochondria
  • response to salt stress
  • T cell proliferation involved in immune response
  • gene expression
  • mitochondrial DNA repair
  • positive regulation of execution phase of apoptosis
  • positive regulation of mitochondrial membrane permeability
  • protein tetramerization
  • negative regulation of transcription, DNA-templated
  • positive regulation of intrinsic apoptotic signaling pathway
  • B cell lineage commitment
  • regulation of apoptotic process
  • cerebellum development
  • positive regulation of protein oligomerization
  • response to antibiotic
  • positive regulation of thymocyte apoptotic process
  • apoptotic process
  • protein localization
  • T cell lineage commitment
  • transcription initiation from RNA polymerase II promoter
  • neuron apoptotic process
  • positive regulation of histone deacetylation
  • DNA repair
  • regulation of fibroblast apoptotic process
  • negative regulation of apoptotic process
  • negative regulation of cell growth
  • regulation of mitochondrial membrane permeability
  • in utero embryonic development
  • cellular response to hypoxia
  • cellular response to glucose starvation
  • cell aging
  • regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of cell proliferation
  • viral process
  • regulation of mitochondrial membrane permeability involved in apoptotic process
  • regulation of tissue remodeling
  • cellular response to drug
  • regulation of cellular senescence
  • programmed cell death
  • regulation of intrinsic apoptotic signaling pathway by p53 class mediator
  • positive regulation of transcription from RNA polymerase II promoter
  • protein import into nucleus, translocation
  • negative regulation of DNA replication
  • necroptotic process
  • T cell differentiation in thymus
  • intrinsic apoptotic signaling pathway by p53 class mediator
  • Ras protein signal transduction
  • response to X-ray
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • transforming growth factor beta receptor signaling pathway
  • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
  • multicellular organismal development
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • mitotic G1 DNA damage checkpoint
  • cell differentiation
  • positive regulation of gene expression
  • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
  • cell cycle arrest
  • negative regulation of proteolysis
  • cellular response to UV
  • ER overload response
Components
  • cytoplasm
  • nuclear chromatin
  • mitochondrion
  • protein complex
  • nuclear matrix
  • nucleus
  • replication fork
  • endoplasmic reticulum
  • mitochondrial matrix
  • cytosol
  • nucleolus
  • nucleoplasm
  • PML body
General FunctionNot Available
Specific FunctionNot Available
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP04637
UniProtKB Entry NameP53_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0021858|Cellular tumor antigen p53 (TP53)
ATGGAGGAGCCGCAGTCAGATCCTAGCGTCGAGCCCCCTCTGAGTCAGGAAACATTTTCA
GACCTATGGAAACTACTTCCTGAAAACAACGTTCTGTCCCCCTTGCCGTCCCAAGCAATG
GATGATTTGATGCTGTCCCCGGACGATATTGAACAATGGTTCACTGAAGACCCAGGTCCA
GATGAAGCTCCCAGAATGCCAGAGGCTGCTCCCCCCGTGGCCCCTGCACCAGCAGCTCCT
ACACCGGCGGCCCCTGCACCAGCCCCCTCCTGGCCCCTGTCATCTTCTGTCCCTTCCCAG
AAAACCTACCAGGGCAGCTACGGTTTCCGTCTGGGCTTCTTGCATTCTGGGACAGCCAAG
TCTGTGACTTGCACGTACTCCCCTGCCCTCAACAAGATGTTTTGCCAACTGGCCAAGACC
TGCCCTGTGCAGCTGTGGGTTGATTCCACACCCCCGCCCGGCACCCGCGTCCGCGCCATG
GCCATCTACAAGCAGTCACAGCACATGACGGAGGTTGTGAGGCGCTGCCCCCACCATGAG
CGCTGCTCAGATAGCGATGGTCTGGCCCCTCCTCAGCATCTTATCCGAGTGGAAGGAAAT
TTGCGTGTGGAGTATTTGGATGACAGAAACACTTTTCGACATAGTGTGGTGGTGCCCTAT
GAGCCGCCTGAGGTTGGCTCTGACTGTACCACCATCCACTACAACTACATGTGTAACAGT
TCCTGCATGGGCGGCATGAACCGGAGGCCCATCCTCACCATCATCACACTGGAAGACTCC
AGTGGTAATCTACTGGGACGGAACAGCTTTGAGGTGCGTGTTTGTGCCTGTCCTGGGAGA
GACCGGCGCACAGAGGAAGAGAATCTCCGCAAGAAAGGGGAGCCTCACCACGAGCTGCCC
CCAGGGAGCACTAAGCGAGCACTGCCCAACAACACCAGCTCCTCTCCCCAGCCAAAGAAG
AAACCACTGGATGGAGAATATTTCACCCTTCAGATCCGTGGGCGTGAGCGCTTCGAGATG
TTCCGAGAGCTGAATGAGGCCTTGGAACTCAAGGATGCCCAGGCTGGGAAGGAGCCAGGG
GGGAGCAGGGCTCACTCCAGCCACCTGAAGTCCAAAAAGGGTCAGTCTACCTCCCGCCAT
AAAAAACTCATGTTCAAGACAGAAGGGCCTGACTCAGACTGA
GenBank Gene IDX02469
GeneCard IDNot Available
GenAtlas IDTP53
HGNC IDHGNC:11998
Chromosome LocationNot Available
Locus17p13.1
References
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