Intercellular adhesion molecule 1

NameIntercellular adhesion molecule 1
Synonyms
  • ICAM-1
  • Major group rhinovirus receptor
Gene NameICAM1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020504|Intercellular adhesion molecule 1
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGI
ETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAP
LPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHH
GANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLD
GLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQE
TLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKA
TPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQ
AWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYE
IVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
Number of residues532
Molecular Weight57824.785
Theoretical pI8.06
GO Classification
Functions
  • receptor activity
  • transmembrane signaling receptor activity
  • integrin binding
  • virus receptor activity
Processes
  • adhesion of symbiont to host
  • response to gonadotropin
  • positive regulation of peptidyl-tyrosine phosphorylation
  • response to organic cyclic compound
  • T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
  • positive regulation of ERK1 and ERK2 cascade
  • T cell antigen processing and presentation
  • leukocyte cell-cell adhesion
  • cellular response to hypoxia
  • cellular response to tumor necrosis factor
  • positive regulation of nitric oxide biosynthetic process
  • cellular response to nutrient levels
  • response to amino acid
  • extracellular matrix organization
  • cellular response to glucose stimulus
  • negative regulation of endothelial cell apoptotic process
  • leukocyte migration
  • positive regulation of NF-kappaB transcription factor activity
  • response to ethanol
  • regulation of immune response
  • cellular response to interleukin-1
  • sensory perception of sound
  • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
  • receptor-mediated virion attachment to host cell
  • cell adhesion
  • positive regulation of cellular extravasation
  • regulation of ruffle assembly
  • response to drug
  • response to copper ion
  • response to amphetamine
  • cell aging
  • positive regulation of actin filament polymerization
  • positive regulation of GTPase activity
  • membrane to membrane docking
  • establishment of endothelial barrier
  • response to ionizing radiation
  • cellular response to lipopolysaccharide
  • cellular response to alkaloid
  • cell adhesion mediated by integrin
  • regulation of cell shape
  • negative regulation of calcium ion transport
  • cytokine-mediated signaling pathway
  • response to sulfur dioxide
  • acute inflammatory response to antigenic stimulus
  • positive regulation of vasoconstriction
  • establishment of Sertoli cell barrier
  • regulation of cell adhesion
  • interferon-gamma-mediated signaling pathway
  • regulation of leukocyte mediated cytotoxicity
  • ovarian follicle development
Components
  • focal adhesion
  • external side of plasma membrane
  • integral component of plasma membrane
  • membrane
  • immunological synapse
  • membrane raft
  • plasma membrane
  • extracellular space
  • cell surface
  • extracellular exosome
General FunctionVirus receptor activity
Specific FunctionICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins (PubMed:1968231, PubMed:2538243). Acts as a receptor for Coxsackievirus A21 capsid proteins (PubMed:11160747, PubMed:16004874, PubMed:9539703). Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell (PubMed:11413168).
Pfam Domain Function
Transmembrane Regions481-503
GenBank Protein ID758074
UniProtKB IDP05362
UniProtKB Entry NameICAM1_HUMAN
Cellular LocationMembrane
Gene sequence
>lcl|BSEQ0020505|Intercellular adhesion molecule 1 (ICAM1)
ATGGCTCCCAGCAGCCCCCGGCCCGCGCTGCCCGCACTCCTGGTCCTGCTCGGGGCTCTG
TTCCCAGGACCTGGCAATGCCCAGACATCTGTGTCCCCCTCAAAAGTCATCCTGCCCCGG
GGAGGCTCCGTGCTGGTGACATGCAGCACCTCCTGTGACCAGCCCAAGTTGTTGGGCATA
GAGACCCCGTTGCCTAAAAAGGAGTTGCTCCTGCCTGGGAACAACCGGAAGGTGTATGAA
CTGAGCAATGTGCAAGAAGATAGCCAACCAATGTGCTATTCAAACTGCCCTGATGGGCAG
TCAACAGCTAAAACCTTCCTCACCGTGTACTGGACTCCAGAACGGGTGGAACTGGCACCC
CTCCCCTCTTGGCAGCCAGTGGGCAAGAACCTTACCCTACGCTGCCAGGTGGAGGGTGGG
GCACCCCGGGCCAACCTCACCGTGGTGCTGCTCCGTGGGGAGAAGGAGCTGAAACGGGAG
CCAGCTGTGGGGGAGCCCGCTGAGGTCACGACCACGGTGCTGGTGAGGAGAGATCACCAT
GGAGCCAATTTCTCGTGCCGCACTGAACTGGACCTGCGGCCCCAAGGGCTGGAGCTGTTT
GAGAACACCTCGGCCCCCTACCAGCTCCAGACCTTTGTCCTGCCAGCGACTCCCCCACAA
CTTGTCAGCCCCCGGGTCCTAGAGGTGGACACGCAGGGGACCGTGGTCTGTTCCCTGGAC
GGGCTGTTCCCAGTCTCGGAGGCCCAGGTCCACCTGGCACTGGGGGACCAGAGGTTGAAC
CCCACAGTCACCTATGGCAACGACTCCTTCTCGGCCAAGGCCTCAGTCAGTGTGACCGCA
GAGGACGAGGGCACCCAGCGGCTGACGTGTGCAGTAATACTGGGGAACCAGAGCCAGGAG
ACACTGCAGACAGTGACCATCTACAGCTTTCCGGCGCCCAACGTGATTCTGACGAAGCCA
GAGGTCTCAGAAGGGACCGAGGTGACAGTGAAGTGTGAGGCCCACCCTAGAGCCAAGGTG
ACGCTGAATGGGGTTCCAGCCCAGCCACTGGGCCCGAGGGCCCAGCTCCTGCTGAAGGCC
ACCCCAGAGGACAACGGGCGCAGCTTCTCCTGCTCTGCAACCCTGGAGGTGGCCGGCCAG
CTTATACACAAGAACCAGACCCGGGAGCTTCGTGTCCTGTATGGCCCCCGACTGGACGAG
AGGGATTGTCCGGGAAACTGGACGTGGCCAGAAAATTCCCAGCAGACTCCAATGTGCCAG
GCTTGGGGGAACCCATTGCCCGAGCTCAAGTGTCTAAAGGATGGCACTTTCCCACTGCCC
ATCGGGGAATCAGTGACTGTCACTCGAGATCTTGAGGGCACCTACCTCTGTCGGGCCAGG
AGCACTCAAGGGGAGGTCACCCGCAAGGTGACCGTGAATGTGCTCTCCCCCCGGTATGAG
ATTGTCATCATCACTGTGGTAGCAGCCGCAGTCATAATGGGCACTGCAGGCCTCAGCACG
TACCTCTATAACCGCCAGCGGAAGATCAAGAAATACAGACTACAACAGGCCCAAAAAGGG
ACCCCCATGAAACCGAACACACAAGCCACGCCTCCCTGA
GenBank Gene IDX06990
GeneCard IDNot Available
GenAtlas IDICAM1
HGNC IDHGNC:5344
Chromosome Location19
Locus19p13.3-p13.2
References
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