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NameTranscription factor AP-1
Synonyms
  • Activator protein 1
  • AP1
  • p39
  • Proto-oncogene c-Jun
  • V-jun avian sarcoma virus 17 oncogene homolog
Gene NameJUN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016292|Transcription factor AP-1
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Number of residues331
Molecular Weight35675.32
Theoretical pI9.11
GO Classification
Functions
  • DNA binding
  • RNA polymerase II distal enhancer sequence-specific DNA binding
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • transcriptional activator activity, RNA polymerase II transcription factor binding
  • chromatin binding
  • transcription factor binding
  • transcription factor activity, sequence-specific DNA binding
  • poly(A) RNA binding
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • enzyme binding
  • GTPase activator activity
  • transcription coactivator activity
  • R-SMAD binding
  • RNA polymerase II activating transcription factor binding
  • transcription regulatory region DNA binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • cAMP response element binding
Processes
  • response to cAMP
  • positive regulation of monocyte differentiation
  • MyD88-dependent toll-like receptor signaling pathway
  • liver development
  • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • response to hydrogen peroxide
  • positive regulation of fibroblast proliferation
  • MyD88-independent toll-like receptor signaling pathway
  • toll-like receptor 4 signaling pathway
  • transforming growth factor beta receptor signaling pathway
  • positive regulation by host of viral transcription
  • negative regulation of cell proliferation
  • regulation of sequence-specific DNA binding transcription factor activity
  • response to drug
  • toll-like receptor 5 signaling pathway
  • aging
  • positive regulation of pri-miRNA transcription from RNA polymerase II promoter
  • regulation of cell death
  • positive regulation of transcription from RNA polymerase II promoter
  • stress-activated MAPK cascade
  • regulation of cell cycle
  • toll-like receptor 9 signaling pathway
  • positive regulation of endothelial cell proliferation
  • response to cytokine
  • response to muscle stretch
  • toll-like receptor 10 signaling pathway
  • toll-like receptor signaling pathway
  • negative regulation of neuron apoptotic process
  • circadian rhythm
  • negative regulation by host of viral transcription
  • toll-like receptor 2 signaling pathway
  • toll-like receptor TLR1
  • cellular response to hormone stimulus
  • outflow tract morphogenesis
  • toll-like receptor 3 signaling pathway
  • response to radiation
  • toll-like receptor TLR6
  • TRIF-dependent toll-like receptor signaling pathway
  • response to lipopolysaccharide
  • negative regulation of transcription, DNA-templated
  • positive regulation of GTPase activity
  • negative regulation of protein autophosphorylation
  • cellular response to potassium ion starvation
  • angiogenesis
  • SMAD protein signal transduction
  • positive regulation of DNA replication
  • SMAD protein import into nucleus
  • axon regeneration
  • learning
  • negative regulation of DNA binding
  • innate immune response
  • cellular response to calcium ion
  • regulation of cell proliferation
  • positive regulation of DNA-templated transcription, initiation
  • membrane depolarization
  • Fc-epsilon receptor signaling pathway
  • release of cytochrome c from mitochondria
  • positive regulation of neuron apoptotic process
  • positive regulation of smooth muscle cell proliferation
  • leading edge cell differentiation
  • positive regulation of transcription, DNA-templated
  • positive regulation of cell differentiation
  • monocyte differentiation
  • response to mechanical stimulus
  • microglial cell activation
Components
  • nucleus
  • nuclear euchromatin
  • transcription factor complex
  • cytosol
  • transcriptional repressor complex
  • nucleoplasm
  • nuclear chromosome
General FunctionTranscriptional activator activity, rna polymerase ii transcription factor binding
Specific FunctionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID386839
UniProtKB IDP05412
UniProtKB Entry NameJUN_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016293|Transcription factor AP-1 (JUN)
ATGACTGCAAAGATGGAAACGACCTTCTATGACGATGCCCTCAACGCCTCGTTCCTCCCG
TCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGATCCTGAAACAGAGCATGACCCTG
AACCTGGCCGACCCAGTGGGGAGCCTGAAGCCGCACCTCCGCGCCAAGAACTCGGACCTC
CTCACCTCGCCCGACGTGGGGCTGCTCAAGCTGGCGTCGCCCGAGCTGGAGCGCCTGATA
ATCCAGTCCAGCAACGGGCACATCACCACCACGCCGACCCCCACCCAGTTCCTGTGCCCC
AAGAACGTGACAGATGAGCAGGAGGGCTTCGCCGAGGGCTTCGTGCGCGCCCTGGCCGAA
CTGCACAGCCAGAACACGCTGCCCAGCGTCACGTCGGCGGCGCAGCCGGTCAACGGGGCA
GGCATGGTGGCTCCCGCGGTAGCCTCGGTGGCAGGGGGCAGCGGCAGCGGCGGCTTCAGC
GCCAGCCTGCACAGCGAGCCGCCGGTCTACGCAAACCTCAGCAACTTCAACCCAGGCGCG
CTGAGCAGCGGCGGCGGGGCGCCCTCCTACGGCGCGGCCGGCCTGGCCTTTCCCGCGCAA
CCCCAGCAGCAGCAGCAGCCGCCGCACCACCTGCCCCAGCAGATGCCCGTGCAGCACCCG
CGGCTGCAGGCCCTGAAGGAGGAGCCTCAGACAGTGCCCGAGATGCCCGGCGAGACACCG
CCCCTGTCCCCCATCGACATGGAGTCCCAGGAGCGGATCAAGGCGGAGAGGAAGCGCATG
AGGAACCGCATCGCTGCCTCCAAGTGCCGAAAAAGGAAGCTGGAGAGAATCGCCCGGCTG
GAGGAAAAAGTGAAAACCTTGAAAGCTCAGAACTCGGAGCTGGCGTCCACGGCCAACATG
CTCAGGGAACAGGTGGCACAGCTTAAACAGAAAGTCATGAACCACGTTAACAGTGGGTGC
CAACTCATGCTAACGCAGCAGTTGCAAACATTTTGA
GenBank Gene IDJ04111
GeneCard IDNot Available
GenAtlas IDJUN
HGNC IDHGNC:6204
Chromosome Location1
Locus1p32-p31
References
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