Transcription factor AP-1

NameTranscription factor AP-1
Synonyms
  • Activator protein 1
  • AP1
  • p39
  • Proto-oncogene c-Jun
  • V-jun avian sarcoma virus 17 oncogene homolog
Gene NameJUN
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016292|Transcription factor AP-1
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDL
LTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAE
LHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGA
LSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETP
PLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANM
LREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
Number of residues331
Molecular Weight35675.32
Theoretical pI9.11
GO Classification
Functions
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • R-SMAD binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • RNA polymerase II activating transcription factor binding
  • transcription regulatory region DNA binding
  • DNA binding
  • cAMP response element binding
  • chromatin binding
  • RNA polymerase II distal enhancer sequence-specific DNA binding
  • transcription factor binding
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • transcription factor activity, sequence-specific DNA binding
  • transcriptional activator activity, RNA polymerase II transcription factor binding
  • enzyme binding
  • poly(A) RNA binding
  • GTPase activator activity
  • transcription coactivator activity
Processes
  • positive regulation of DNA replication
  • TRIF-dependent toll-like receptor signaling pathway
  • learning
  • negative regulation of protein autophosphorylation
  • axon regeneration
  • cellular response to calcium ion
  • SMAD protein signal transduction
  • innate immune response
  • membrane depolarization
  • SMAD protein import into nucleus
  • regulation of cell proliferation
  • positive regulation of smooth muscle cell proliferation
  • negative regulation of DNA binding
  • Fc-epsilon receptor signaling pathway
  • positive regulation of neuron apoptotic process
  • response to mechanical stimulus
  • positive regulation of transcription, DNA-templated
  • monocyte differentiation
  • MyD88-dependent toll-like receptor signaling pathway
  • liver development
  • response to cAMP
  • positive regulation of DNA-templated transcription, initiation
  • MyD88-independent toll-like receptor signaling pathway
  • transforming growth factor beta receptor signaling pathway
  • leading edge cell differentiation
  • response to hydrogen peroxide
  • release of cytochrome c from mitochondria
  • regulation of sequence-specific DNA binding transcription factor activity
  • response to drug
  • aging
  • microglial cell activation
  • negative regulation of cell proliferation
  • positive regulation of cell differentiation
  • stress-activated MAPK cascade
  • regulation of cell cycle
  • positive regulation of endothelial cell proliferation
  • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of monocyte differentiation
  • response to muscle stretch
  • positive regulation of fibroblast proliferation
  • toll-like receptor 10 signaling pathway
  • toll-like receptor 4 signaling pathway
  • response to cytokine
  • positive regulation by host of viral transcription
  • circadian rhythm
  • toll-like receptor 2 signaling pathway
  • toll-like receptor 5 signaling pathway
  • negative regulation of neuron apoptotic process
  • positive regulation of pri-miRNA transcription from RNA polymerase II promoter
  • cellular response to hormone stimulus
  • toll-like receptor 3 signaling pathway
  • response to radiation
  • toll-like receptor 9 signaling pathway
  • regulation of cell death
  • response to lipopolysaccharide
  • toll-like receptor signaling pathway
  • positive regulation of GTPase activity
  • negative regulation by host of viral transcription
  • toll-like receptor TLR1
  • negative regulation of transcription, DNA-templated
  • angiogenesis
  • outflow tract morphogenesis
  • toll-like receptor TLR6
  • cellular response to potassium ion starvation
Components
  • cytosol
  • transcriptional repressor complex
  • nucleoplasm
  • nuclear euchromatin
  • transcription factor complex
  • nuclear chromosome
  • nucleus
General FunctionTranscriptional activator activity, rna polymerase ii transcription factor binding
Specific FunctionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID386839
UniProtKB IDP05412
UniProtKB Entry NameJUN_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0016293|Transcription factor AP-1 (JUN)
ATGACTGCAAAGATGGAAACGACCTTCTATGACGATGCCCTCAACGCCTCGTTCCTCCCG
TCCGAGAGCGGACCTTATGGCTACAGTAACCCCAAGATCCTGAAACAGAGCATGACCCTG
AACCTGGCCGACCCAGTGGGGAGCCTGAAGCCGCACCTCCGCGCCAAGAACTCGGACCTC
CTCACCTCGCCCGACGTGGGGCTGCTCAAGCTGGCGTCGCCCGAGCTGGAGCGCCTGATA
ATCCAGTCCAGCAACGGGCACATCACCACCACGCCGACCCCCACCCAGTTCCTGTGCCCC
AAGAACGTGACAGATGAGCAGGAGGGCTTCGCCGAGGGCTTCGTGCGCGCCCTGGCCGAA
CTGCACAGCCAGAACACGCTGCCCAGCGTCACGTCGGCGGCGCAGCCGGTCAACGGGGCA
GGCATGGTGGCTCCCGCGGTAGCCTCGGTGGCAGGGGGCAGCGGCAGCGGCGGCTTCAGC
GCCAGCCTGCACAGCGAGCCGCCGGTCTACGCAAACCTCAGCAACTTCAACCCAGGCGCG
CTGAGCAGCGGCGGCGGGGCGCCCTCCTACGGCGCGGCCGGCCTGGCCTTTCCCGCGCAA
CCCCAGCAGCAGCAGCAGCCGCCGCACCACCTGCCCCAGCAGATGCCCGTGCAGCACCCG
CGGCTGCAGGCCCTGAAGGAGGAGCCTCAGACAGTGCCCGAGATGCCCGGCGAGACACCG
CCCCTGTCCCCCATCGACATGGAGTCCCAGGAGCGGATCAAGGCGGAGAGGAAGCGCATG
AGGAACCGCATCGCTGCCTCCAAGTGCCGAAAAAGGAAGCTGGAGAGAATCGCCCGGCTG
GAGGAAAAAGTGAAAACCTTGAAAGCTCAGAACTCGGAGCTGGCGTCCACGGCCAACATG
CTCAGGGAACAGGTGGCACAGCTTAAACAGAAAGTCATGAACCACGTTAACAGTGGGTGC
CAACTCATGCTAACGCAGCAGTTGCAAACATTTTGA
GenBank Gene IDJ04111
GeneCard IDNot Available
GenAtlas IDJUN
HGNC IDHGNC:6204
Chromosome Location1
Locus1p32-p31
References
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