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NameHistone H2B type 1-J
Synonyms
  • H2B/r
  • H2BFR
  • Histone H2B.1
  • Histone H2B.r
Gene NameHIST1H2BJ
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021424|Histone H2B type 1-J
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT
KYTSAK
Number of residues126
Molecular Weight13904.055
Theoretical pINot Available
GO Classification
Functions
  • DNA binding
Processes
  • antibacterial humoral response
  • defense response to Gram-positive bacterium
  • innate immune response in mucosa
  • chromatin organization
  • nucleosome assembly
Components
  • cytoplasm
  • nucleus
  • extracellular space
  • nucleoplasm
  • nuclear nucleosome
  • nucleosome
General FunctionDna binding
Specific FunctionCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP06899
UniProtKB Entry NameH2B1J_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021425|Histone H2B type 1-J (HIST1H2BJ)
ATGCCAGAGCCAGCGAAGTCTGCTCCCGCCCCGAAAAAGGGCTCCAAGAAGGCGGTGACT
AAGGCGCAGAAGAAAGACGGCAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTATTCCATC
TATGTGTACAAGGTTCTGAAGCAGGTCCACCCTGACACCGGCATTTCGTCCAAGGCCATG
GGCATCATGAATTCGTTTGTGAACGACATTTTCGAGCGCATCGCAGGTGAGGCTTCCCGC
CTGGCGCATTACAACAAGCGCTCGACCATCACCTCCAGGGAGATCCAGACGGCCGTGCGC
CTGCTGCTGCCTGGGGAGTTGGCCAAGCACGCCGTGTCCGAGGGTACTAAGGCCGTCACC
AAGTACACCAGCGCTAAGTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4761
Chromosome Location6
LocusNot Available
References
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