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Trypsin-1

NameTrypsin-1
Synonyms
  • 3.4.21.4
  • Beta-trypsin
  • Cationic trypsinogen
  • Serine protease 1
  • TRP1
  • TRY1
  • TRYP1
  • Trypsin I
Gene NamePRSS1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0016543|Trypsin-1
MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVS
AGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVIN
ARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKIT
SNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIK
NTIAANS
Number of residues247
Molecular Weight26557.88
Theoretical pI6.48
GO Classification
Functions
  • serine-type endopeptidase activity
  • metal ion binding
Processes
  • extracellular matrix disassembly
  • extracellular matrix organization
  • vitamin metabolic process
  • water-soluble vitamin metabolic process
  • cobalamin metabolic process
  • proteolysis
  • digestion
  • small molecule metabolic process
Components
  • blood microparticle
  • extracellular region
  • extracellular space
  • extracellular exosome
General FunctionSerine-type endopeptidase activity
Specific FunctionHas activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID521216
UniProtKB IDP07477
UniProtKB Entry NameTRY1_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0016544|Trypsin-1 (PRSS1)
ATGAATCCACTCCTGATCCTTACCTTTGTGGCAGCTGCTCTTGCTGCCCCCTTTGATGAT
GATGACAAGATCGTTGGGGGCTACAACTGTGAGGAGAATTCTGTCCCCTACCAGGTGTCC
CTGAATTCTGGCTACCACTTCTGTGGTGGCTCCCTCATCAACGAACAGTGGGTGGTATCA
GCAGGCCACTGCTACAAGTCCCGCATCCAGGTGAGACTGGGAGAGCACAACATCGAAGTC
CTGGAGGGGAATGAGCAGTTCATCAATGCAGCCAAGATCATCCGCCACCCCCAATACGAC
AGGAAGACTCTGAACAATGACATCATGTTAATCAAGCTCTCCTCACGTGCAGTAATCAAC
GCCCGCGTGTCCACCATCTCTCTGCCCACCGCCCCTCCAGCCACTGGCACGAAGTGCCTC
ATCTCTGGCTGGGGCAACACTGCGAGCTCTGGCGCCGACTACCCAGACGAGCTGCAGTGC
CTGGATGCTCCTGTGCTGAGCCAGGCTAAGTGTGAAGCCTCCTACCCTGGAAAGATTACC
AGCAACATGTTCTGTGTGGGCTTCCTTGAGGGAGGCAAGGATTCATGTCAGGGTGATTCT
GGTGGCCCTGTGGTCTGCAATGGACAGCTCCAAGGAGTTGTCTCCTGGGGTGATGGCTGT
GCCCAGAAGAACAAGCCTGGAGTCTACACCAAGGTCTACAACTATGTGAAATGGATTAAG
AACACCATAGCTGCCAATAGCTAA
GenBank Gene IDM22612
GeneCard IDNot Available
GenAtlas IDPRSS1
HGNC IDHGNC:9475
Chromosome Location7
Locus7q32-qter|7q34
References
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