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NameCathepsin B
Synonyms
  • 3.4.22.1
  • APP secretase
  • APPS
  • Cathepsin B1
  • CPSB
Gene NameCTSB
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019038|Cathepsin B
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCG
TFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSW
NTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Number of residues339
Molecular Weight37821.35
Theoretical pI6.27
GO Classification
Functions
  • peptidase activity
  • cysteine-type endopeptidase activity
  • cysteine-type peptidase activity
  • peptide binding
  • proteoglycan binding
  • collagen binding
Processes
  • collagen catabolic process
  • spermatogenesis
  • decidualization
  • extracellular matrix disassembly
  • response to organic cyclic compound
  • extracellular matrix organization
  • proteolysis
  • skeletal muscle tissue development
  • response to peptide hormone
  • epithelial cell differentiation
  • negative regulation of cell death
  • response to wounding
  • toll-like receptor signaling pathway
  • regulation of apoptotic process
  • cellular response to thyroid hormone stimulus
  • proteolysis involved in cellular protein catabolic process
  • regulation of catalytic activity
  • response to ethanol
  • autophagy
  • response to interleukin-4
  • response to amine
  • innate immune response
  • viral entry into host cell
  • response to glucose
  • cellular response to mechanical stimulus
Components
  • mitochondrion
  • extracellular region
  • intracellular membrane-bounded organelle
  • extracellular space
  • lysosome
  • endolysosome lumen
  • apical plasma membrane
  • caveola
  • extracellular exosome
  • sarcolemma
  • nucleolus
  • melanosome
  • perinuclear region of cytoplasm
  • external side of plasma membrane
  • intracellular
General FunctionProteoglycan binding
Specific FunctionThiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181192
UniProtKB IDP07858
UniProtKB Entry NameCATB_HUMAN
Cellular LocationLysosome
Gene sequence
>lcl|BSEQ0019039|Cathepsin B (CTSB)
ATGTGGCAGCTCTGGGCCTCCCTCTGCTGCCTGCTGGTGTTGGCCAATGCCCGGAGCAGG
CCCTCTTTCCATCCCCTGTCGGATGAGCTGGTCAACTATGTCAACAAACGGAATACCACG
TGGCAGGCCGGGCACAACTTCTACAACGTGGACATGAGCTACTTGAAGAGGCTATGTGGT
ACCTTCCTGGGTGGGCCCAAGCCACCCCAGAGAGTTATGTTTACCGAGGACCTGAAGCTG
CCTGCAAGCTTCGATGCACGGGAACAATGGCCACAGTGTCCCACCATCAAAGAGATCAGA
GACCAGGGCTCCTGTGGCTCCTGCTGGGCCTTCGGGGCTGTGGAAGCCATCTCTGACCGG
ATCTGCATCCACACCAATGCGCACGTCAGCGTGGAGGTGTCGGCGGAGGACCTGCTCACA
TGCTGTGGCAGCATGTGTGGGGACGGCTGTAATGGTGGCTATCCTGCTGAAGCTTGGAAC
TTCTGGACAAGAAAAGGCCTGGTTTCTGGTGGCCTCTATGAATCCCATGTAGGGTGCAGA
CCGTACTCCATCCCTCCCTGTGAGCACCACGTCAACGGCTCCCGGCCCCCATGCACGGGG
GAGGGAGATACCCCCAAGTGTAGCAAGATCTGTGAGCCTGGCTACAGCCCGACCTACAAA
CAGGACAAGCACTACGGATACAATTCCTACAGCGTCTCCAATAGCGAGAAGGACATCATG
GCCGAGATCTACAAAAACGGCCCCGTGGAGGGAGCTTTCTCTGTGTATTCGGACTTCCTG
CTCTACAAGTCAGGAGTGTACCAACACGTCACCGGAGAGATGATGGGTGGCCATGCCATC
CGCATCCTGGGCTGGGGAGTGGAGAATGGCACACCCTACTGGCTGGTTGCCAACTCCTGG
AACACTGACTGGGGTGACAATGGCTTCTTTAAAATACTCAGAGGACAGGATCACTGTGGA
ATCGAATCAGAAGTGGTGGCTGGAATTCCACGCACCGATCAGTACTGGGAAAAGATCTAA
GenBank Gene IDM14221
GeneCard IDNot Available
GenAtlas IDCTSB
HGNC IDHGNC:2527
Chromosome Location8
Locus8p22
References
  1. Chan SJ, San Segundo B, McCormick MB, Steiner DF: Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. Proc Natl Acad Sci U S A. 1986 Oct;83(20):7721-5. 3463996
  2. Cao L, Taggart RT, Berquin IM, Moin K, Fong D, Sloane BF: Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. Gene. 1994 Feb 25;139(2):163-9. 8112600
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  6. Ritonja A, Popovic T, Turk V, Wiedenmann K, Machleidt W: Amino acid sequence of human liver cathepsin B. FEBS Lett. 1985 Feb 11;181(1):169-72. 3972105
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  9. Basrur V, Yang F, Kushimoto T, Higashimoto Y, Yasumoto K, Valencia J, Muller J, Vieira WD, Watabe H, Shabanowitz J, Hearing VJ, Hunt DF, Appella E: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. J Proteome Res. 2003 Jan-Feb;2(1):69-79. 12643545
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