Glutathione S-transferase P

NameGlutathione S-transferase P
Synonyms
  • 2.5.1.18
  • FAEES3
  • GST class-pi
  • GST3
  • GSTP1-1
Gene NameGSTP1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010574|Glutathione S-transferase P
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
Number of residues210
Molecular Weight23355.625
Theoretical pI5.3
GO Classification
Functions
  • S-nitrosoglutathione binding
  • nitric oxide binding
  • glutathione transferase activity
  • kinase regulator activity
  • dinitrosyl-iron complex binding
  • JUN kinase binding
Processes
  • positive regulation of superoxide anion generation
  • common myeloid progenitor cell proliferation
  • regulation of stress-activated MAPK cascade
  • negative regulation of biosynthetic process
  • negative regulation of apoptotic process
  • response to reactive oxygen species
  • negative regulation of ERK1 and ERK2 cascade
  • cellular response to lipopolysaccharide
  • negative regulation of fibroblast proliferation
  • xenobiotic metabolic process
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • negative regulation of extrinsic apoptotic signaling pathway
  • negative regulation of interleukin-1 beta production
  • negative regulation of JUN kinase activity
  • negative regulation of acute inflammatory response
  • glutathione metabolic process
  • negative regulation of leukocyte proliferation
  • glutathione derivative biosynthetic process
  • negative regulation of MAPK cascade
  • central nervous system development
  • negative regulation of monocyte chemotactic protein-1 production
  • regulation of ERK1 and ERK2 cascade
  • negative regulation of nitric-oxide synthase biosynthetic process
  • negative regulation of MAP kinase activity
  • negative regulation of stress-activated MAPK cascade
  • negative regulation of tumor necrosis factor production
  • negative regulation of protein kinase activity
  • negative regulation of tumor necrosis factor-mediated signaling pathway
  • small molecule metabolic process
  • nitric oxide storage
Components
  • cytosol
  • extracellular exosome
  • intracellular
  • cytoplasm
  • mitochondrion
  • nucleus
  • extracellular space
  • vesicle
  • TRAF2-GSTP1 complex
General FunctionS-nitrosoglutathione binding
Specific FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31946
UniProtKB IDP09211
UniProtKB Entry NameGSTP1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010575|Glutathione S-transferase P (GSTP1)
ATGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATG
CTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAG
GAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGAC
CTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT
GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTC
CGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTG
AAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGC
AAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTG
CTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATAT
GTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG
AACCTCCCCATCAATGGCAACGGGAAACAGTGA
GenBank Gene IDM24485
GeneCard IDNot Available
GenAtlas IDGSTP1
HGNC IDHGNC:4638
Chromosome Location11
Locus11q13
References
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