Canmetcon
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NameGlutathione S-transferase P
Synonyms
  • 2.5.1.18
  • FAEES3
  • GST class-pi
  • GST3
  • GSTP1-1
Gene NameGSTP1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0010574|Glutathione S-transferase P
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
Number of residues210
Molecular Weight23355.625
Theoretical pI5.3
GO Classification
Functions
  • nitric oxide binding
  • kinase regulator activity
  • dinitrosyl-iron complex binding
  • JUN kinase binding
  • S-nitrosoglutathione binding
  • glutathione transferase activity
Processes
  • common myeloid progenitor cell proliferation
  • negative regulation of stress-activated MAPK cascade
  • negative regulation of acute inflammatory response
  • negative regulation of biosynthetic process
  • negative regulation of tumor necrosis factor production
  • glutathione metabolic process
  • negative regulation of ERK1 and ERK2 cascade
  • negative regulation of protein kinase activity
  • negative regulation of tumor necrosis factor-mediated signaling pathway
  • glutathione derivative biosynthetic process
  • negative regulation of fibroblast proliferation
  • small molecule metabolic process
  • nitric oxide storage
  • central nervous system development
  • negative regulation of I-kappaB kinase/NF-kappaB signaling
  • positive regulation of superoxide anion generation
  • regulation of ERK1 and ERK2 cascade
  • negative regulation of interleukin-1 beta production
  • regulation of stress-activated MAPK cascade
  • negative regulation of MAP kinase activity
  • negative regulation of JUN kinase activity
  • negative regulation of apoptotic process
  • response to reactive oxygen species
  • negative regulation of leukocyte proliferation
  • cellular response to lipopolysaccharide
  • negative regulation of MAPK cascade
  • xenobiotic metabolic process
  • negative regulation of monocyte chemotactic protein-1 production
  • negative regulation of extrinsic apoptotic signaling pathway
  • negative regulation of nitric-oxide synthase biosynthetic process
Components
  • vesicle
  • cytosol
  • intracellular
  • extracellular exosome
  • cytoplasm
  • TRAF2-GSTP1 complex
  • mitochondrion
  • nucleus
  • extracellular space
General FunctionS-nitrosoglutathione binding
Specific FunctionConjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31946
UniProtKB IDP09211
UniProtKB Entry NameGSTP1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0010575|Glutathione S-transferase P (GSTP1)
ATGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATG
CTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAG
GAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGAC
CTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT
GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTC
CGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTG
AAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGC
AAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTG
CTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATAT
GTGGGGCGCCTCAGTGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG
AACCTCCCCATCAATGGCAACGGGAAACAGTGA
GenBank Gene IDM24485
GeneCard IDNot Available
GenAtlas IDGSTP1
HGNC IDHGNC:4638
Chromosome Location11
Locus11q13
References
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  2. Cowell IG, Dixon KH, Pemble SE, Ketterer B, Taylor JB: The structure of the human glutathione S-transferase pi gene. Biochem J. 1988 Oct 1;255(1):79-83. 3196325
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  28. Oakley AJ, Lo Bello M, Battistoni A, Ricci G, Rossjohn J, Villar HO, Parker MW: The structures of human glutathione transferase P1-1 in complex with glutathione and various inhibitors at high resolution. J Mol Biol. 1997 Nov 21;274(1):84-100. 9398518
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  30. Ji X, Blaszczyk J, Xiao B, O'Donnell R, Hu X, Herzog C, Singh SV, Zimniak P: Structure and function of residue 104 and water molecules in the xenobiotic substrate-binding site in human glutathione S-transferase P1-1. Biochemistry. 1999 Aug 10;38(32):10231-8. 10441116
  31. Nicotra M, Paci M, Sette M, Oakley AJ, Parker MW, Lo Bello M, Caccuri AM, Federici G, Ricci G: Solution structure of glutathione bound to human glutathione transferase P1-1: comparison of NMR measurements with the crystal structure. Biochemistry. 1998 Mar 3;37(9):3020-7. 9485454
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  33. Federici L, Lo Sterzo C, Pezzola S, Di Matteo A, Scaloni F, Federici G, Caccuri AM: Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases. Cancer Res. 2009 Oct 15;69(20):8025-34. doi: 10.1158/0008-5472.CAN-09-1314. Epub 2009 Oct 6. 19808963