Tmic
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NameCytochrome c oxidase subunit 6C
Synonyms
  • Cytochrome c oxidase polypeptide VIc
Gene NameCOX6C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0012777|Cytochrome c oxidase subunit 6C
MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMK
DFEEMRKAGIFQSVK
Number of residues75
Molecular Weight8781.36
Theoretical pI10.98
GO Classification
Functions
  • cytochrome-c oxidase activity
Processes
  • gene expression
  • small molecule metabolic process
  • transcription initiation from RNA polymerase II promoter
  • cellular metabolic process
  • respiratory electron transport chain
  • generation of precursor metabolites and energy
Components
  • integral component of membrane
  • mitochondrion
  • mitochondrial inner membrane
General FunctionCytochrome-c oxidase activity
Specific FunctionThis protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Pfam Domain Function
Transmembrane Regions14-54
GenBank Protein ID1200057
UniProtKB IDP09669
UniProtKB Entry NameCOX6C_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0012778|Cytochrome c oxidase subunit 6C (COX6C)
ATGGCTCCCGAAGTTTTGCCAAAACCTCGGATGCGTGGCCTTCTGGCCAGGCGTCTGCGA
AATCATATGGCTGTAGCATTCGTGCTATCCCTGGGGGTTGCAGCTTTGTATAAGTTTCGT
GTGGCTGATCAAAGAAAGAAGGCATACGCAGATTTCTACAGAAACTACGATGTCATGAAA
GATTTTGAGGAGATGAGGAAGGCTGGTATCTTTCAGAGTGTAAAGTAA
GenBank Gene IDX13238
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2285
Chromosome Location8
Locus8q22-q23
References
  1. Otsuka M, Mizuno Y, Yoshida M, Kagawa Y, Ohta S: Nucleotide sequence of cDNA encoding human cytochrome c oxidase subunit VIc. Nucleic Acids Res. 1988 Nov 25;16(22):10916. 2849755
  2. Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T: Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22-->q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14-->q21 by FISH and radiation hybrid mapping. Cytogenet Cell Genet. 1998;83(3-4):226-7. 10072584
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