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NameUbiquitin carboxyl-terminal hydrolase isozyme L1
Synonyms
  • 3.4.19.12
  • Neuron cytoplasmic protein 9.5
  • PGP 9.5
  • PGP9.5
  • Ubiquitin thioesterase L1
  • UCH-L1
Gene NameUCHL1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009794|Ubiquitin carboxyl-terminal hydrolase isozyme L1
MQLKPMEINPEMLNKVLSRLGVAGQWRFVDVLGLEEESLGSVPAPACALLLLFPLTAQHE
NFRKKQIEELKGQEVSPKVYFMKQTIGNSCGTIGLIHAVANNQDKLGFEDGSVLKQFLSE
TEKMSPEDRAKCFEKNEAIQAAHDAVAQEGQCRVDDKVNFHFILFNNVDGHLYELDGRMP
FPVNHGASSEDTLLKDAAKVCREFTEREQGEVRFSAVALCKAA
Number of residues223
Molecular Weight24824.17
Theoretical pINot Available
GO Classification
Functions
  • ubiquitin protein ligase binding
  • omega peptidase activity
  • alpha-2A adrenergic receptor binding
  • ligase activity
  • cysteine-type endopeptidase activity
  • ubiquitin binding
  • ubiquitin-specific protease activity
Processes
  • sensory perception of pain
  • neuromuscular process
  • muscle fiber development
  • axon transport of mitochondrion
  • axon target recognition
  • adult walking behavior
  • eating behavior
  • proteasome-mediated ubiquitin-dependent protein catabolic process
  • negative regulation of MAP kinase activity
  • cell proliferation
  • response to ischemia
  • protein deubiquitination
Components
  • neuronal cell body
  • cytoplasm
  • axon
  • endoplasmic reticulum membrane
  • cytosol
  • extracellular exosome
  • myelin sheath
  • nucleoplasm
  • neuron projection terminus
General FunctionUbiquitin-specific protease activity
Specific FunctionUbiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP09936
UniProtKB Entry NameUCHL1_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0020904|Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1)
ATGCAGCTCAAGCCGATGGAGATCAACCCCGAGATGCTGAACAAAGTGCTGTCCCGGCTG
GGGGTCGCCGGCCAGTGGCGCTTCGTGGACGTGCTGGGGCTGGAAGAGGAGTCTCTGGGC
TCGGTGCCAGCGCCTGCCTGCGCGCTGCTGCTGCTGTTTCCCCTCACGGCCCAGCATGAG
AACTTCAGGAAAAAGCAGATTGAAGAGCTGAAGGGACAAGAAGTTAGTCCTAAAGTGTAC
TTCATGAAGCAGACCATTGGGAATTCCTGTGGCACAATCGGACTTATTCACGCAGTGGCC
AATAATCAAGACAAACTGGGATTTGAGGATGGATCAGTTCTGAAACAGTTTCTTTCTGAA
ACAGAGAAAATGTCCCCTGAAGACAGAGCAAAATGCTTTGAAAAGAATGAGGCCATACAG
GCAGCCCATGATGCCGTGGCACAGGAAGGCCAATGTCGGGTAGATGACAAGGTGAATTTC
CATTTTATTCTGTTTAACAACGTGGATGGCCACCTCTATGAACTTGATGGACGAATGCCT
TTTCCGGTGAACCATGGCGCCAGTTCAGAGGACACCCTGCTGAAGGACGCTGCCAAGGTC
TGCAGAGAATTCACCGAGCGTGAGCAAGGAGAAGTCCGCTTCTCTGCCGTGGCTCTCTGC
AAGGCAGCCTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:12513
Chromosome Location4
LocusNot Available
References
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