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NameTransforming growth factor beta-3
Synonyms
  • TGF-beta-3
Gene NameTGFB3
OrganismHuman
Amino acid sequence
>lcl|BSEQ0009427|Transforming growth factor beta-3
MKMHLQRALVVLALLNFATVSLSLSTCTTLDFGHIKKKRVEAIRGQILSKLRLTSPPEPT
VMTHVPYQVLALYNSTRELLEEMHGEREEGCTQENTESEYYAKEIHKFDMIQGLAEHNEL
AVCPKGITSKVFRFNVSSVEKNRTNLFRAEFRVLRVPNPSSKRNEQRIELFQILRPDEHI
AKQRYIGGKNLPTRGTAEWLSFDVTDTVREWLLRRESNLGLEISIHCPCHTFQPNGDILE
NIHEVMEIKFKGVDNEDDHGRGDLGRLKKQKDHHNPHLILMMIPPHRLDNPGQGGQRKKR
ALDTNYCFRNLEENCCVRPLYIDFRQDLGWKWVHEPKGYYANFCSGPCPYLRSADTTHST
VLGLYNTLNPEASASPCCVPQDLEPLTILYYVGRTPKVEQLSNMVVKSCKCS
Number of residues412
Molecular Weight47327.895
Theoretical pINot Available
GO Classification
Functions
  • transforming growth factor beta binding
  • cytokine activity
  • type II transforming growth factor beta receptor binding
  • type III transforming growth factor beta receptor binding
  • identical protein binding
  • type I transforming growth factor beta receptor binding
Processes
  • blood coagulation
  • transforming growth factor beta receptor signaling pathway
  • salivary gland morphogenesis
  • positive regulation of epithelial to mesenchymal transition
  • cell-cell junction organization
  • activation of MAPK activity
  • SMAD protein import into nucleus
  • positive regulation of transcription, DNA-templated
  • positive regulation of SMAD protein import into nucleus
  • uterine wall breakdown
  • negative regulation of cell proliferation
  • SMAD protein signal transduction
  • positive regulation of bone mineralization
  • positive regulation of transcription from RNA polymerase II promoter
  • negative regulation of DNA replication
  • positive regulation of pathway-restricted SMAD protein phosphorylation
  • response to hypoxia
  • negative regulation of transforming growth factor beta receptor signaling pathway
  • aging
  • palate development
  • cell growth
  • negative regulation of neuron apoptotic process
  • platelet degranulation
  • positive regulation of cell division
  • positive regulation of collagen biosynthetic process
  • platelet activation
  • response to estrogen
  • cell development
  • regulation of apoptotic process
  • mammary gland development
  • response to laminar fluid shear stress
  • detection of hypoxia
  • in utero embryonic development
  • response to progesterone
  • positive regulation of DNA replication
  • embryonic neurocranium morphogenesis
  • positive regulation of apoptotic process
  • positive regulation of protein secretion
  • female pregnancy
  • frontal suture morphogenesis
  • regulation of cell proliferation
  • lung alveolus development
  • regulation of MAPK cascade
  • negative regulation of macrophage cytokine production
  • inner ear development
  • ossification involved in bone remodeling
  • extracellular matrix organization
  • digestive tract development
  • positive regulation of filopodium assembly
  • face morphogenesis
  • odontogenesis
Components
  • extracellular region
  • nucleus
  • plasma membrane
  • extracellular space
  • platelet alpha granule lumen
  • cell surface
  • proteinaceous extracellular matrix
  • T-tubule
  • neuronal cell body
  • extracellular matrix
General FunctionType iii transforming growth factor beta receptor binding
Specific FunctionInvolved in embryogenesis and cell differentiation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP10600
UniProtKB Entry NameTGFB3_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0013153|Transforming growth factor beta-3 (TGFB3)
ATGAAGATGCACTTGCAAAGGGCTCTGGTGGTCCTGGCCCTGCTGAACTTTGCCACGGTC
AGCCTCTCTCTGTCCACTTGCACCACCTTGGACTTCGGCCACATCAAGAAGAAGAGGGTG
GAAGCCATTAGGGGACAGATCTTGAGCAAGCTCAGGCTCACCAGCCCCCCTGAGCCAACG
GTGATGACCCACGTCCCCTATCAGGTCCTGGCCCTTTACAACAGCACCCGGGAGCTGCTG
GAGGAGATGCATGGGGAGAGGGAGGAAGGCTGCACCCAGGAAAACACCGAGTCGGAATAC
TATGCCAAAGAAATCCATAAATTCGACATGATCCAGGGGCTGGCGGAGCACAACGAACTG
GCTGTCTGCCCTAAAGGAATTACCTCCAAGGTTTTCCGCTTCAATGTGTCCTCAGTGGAG
AAAAATAGAACCAACCTATTCCGAGCAGAATTCCGGGTCTTGCGGGTGCCCAACCCCAGC
TCTAAGCGGAATGAGCAGAGGATCGAGCTCTTCCAGATCCTTCGGCCAGATGAGCACATT
GCCAAACAGCGCTATATCGGTGGCAAGAATCTGCCCACACGGGGCACTGCCGAGTGGCTG
TCCTTTGATGTCACTGACACTGTGCGTGAGTGGCTGTTGAGAAGAGAGTCCAACTTAGGT
CTAGAAATCAGCATTCACTGTCCATGTCACACCTTTCAGCCCAATGGAGATATCCTGGAA
AACATTCACGAGGTGATGGAAATCAAATTCAAAGGCGTGGACAATGAGGATGACCATGGC
CGTGGAGATCTGGGGCGCCTCAAGAAGCAGAAGGATCACCACAACCCTCATCTAATCCTC
ATGATGATTCCCCCACACCGGCTCGACAACCCGGGCCAGGGGGGTCAGAGGAAGAAGCGG
GCTTTGGACACCAATTACTGCTTCCGCAACTTGGAGGAGAACTGCTGTGTGCGCCCCCTC
TACATTGACTTCCGACAGGATCTGGGCTGGAAGTGGGTCCATGAACCTAAGGGCTACTAT
GCCAACTTCTGCTCAGGCCCTTGCCCATACCTCCGCAGTGCAGACACAACCCACAGCACG
GTGCTGGGACTGTACAACACTCTGAACCCTGAAGCATCTGCCTCGCCTTGCTGCGTGCCC
CAGGACCTGGAGCCCCTGACCATCCTGTACTATGTTGGGAGGACCCCCAAAGTGGAGCAG
CTCTCCAACATGGTGGTGAAGTCTTGTAAATGTAGCTGA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:11769
Chromosome Location14
LocusNot Available
References
  1. ten Dijke P, Hansen P, Iwata KK, Pieler C, Foulkes JG: Identification of another member of the transforming growth factor type beta gene family. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4715-9. 3164476
  2. Derynck R, Lindquist PB, Lee A, Wen D, Tamm J, Graycar JL, Rhee L, Mason AJ, Miller DA, Coffey RJ, et al.: A new type of transforming growth factor-beta, TGF-beta 3. EMBO J. 1988 Dec 1;7(12):3737-43. 3208746
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  5. Arrick BA, Lee AL, Grendell RL, Derynck R: Inhibition of translation of transforming growth factor-beta 3 mRNA by its 5' untranslated region. Mol Cell Biol. 1991 Sep;11(9):4306-13. 1875922
  6. Nakajima M, Kizawa H, Saitoh M, Kou I, Miyazono K, Ikegawa S: Mechanisms for asporin function and regulation in articular cartilage. J Biol Chem. 2007 Nov 2;282(44):32185-92. Epub 2007 Sep 7. 17827158
  7. Mittl PR, Priestle JP, Cox DA, McMaster G, Cerletti N, Grutter MG: The crystal structure of TGF-beta 3 and comparison to TGF-beta 2: implications for receptor binding. Protein Sci. 1996 Jul;5(7):1261-71. 8819159
  8. Beffagna G, Occhi G, Nava A, Vitiello L, Ditadi A, Basso C, Bauce B, Carraro G, Thiene G, Towbin JA, Danieli GA, Rampazzo A: Regulatory mutations in transforming growth factor-beta3 gene cause arrhythmogenic right ventricular cardiomyopathy type 1. Cardiovasc Res. 2005 Feb 1;65(2):366-73. 15639475
  9. Rienhoff HY Jr, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M: A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A. 2013 Aug;161A(8):2040-6. doi: 10.1002/ajmg.a.36056. Epub 2013 Jul 3. 23824657