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NameS-formylglutathione hydrolase
Synonyms
  • 3.1.2.12
  • Esterase D
  • FGH
  • Methylumbelliferyl-acetate deacetylase
Gene NameESD
OrganismHuman
Amino acid sequence
>lcl|BSEQ0004482|S-formylglutathione hydrolase
MALKQISSNKCFGGLQKVFEHDSVELNCKMKFAVYLPPKAETGKCPALYWLSGLTCTEQN
FISKSGYHQSASEHGLVVIAPDTSPRGCNIKGEDESWDFGTGAGFYVDATEDPWKTNYRM
YSYVTEELPQLINANFPVDPQRMSIFGHSMGGHGALICALKNPGKYKSVSAFAPICNPVL
CPWGKKAFSGYLGTDQSKWKAYDATHLVKSYPGSQLDILIDQGKDDQFLLDGQLLPDNFI
AACTEKKIPVVFRLQEGYDHSYYFIATFITDHIRHHAKYLNA
Number of residues282
Molecular Weight31462.545
Theoretical pI7.02
GO Classification
Functions
  • methylumbelliferyl-acetate deacetylase activity
  • S-formylglutathione hydrolase activity
  • hydrolase activity, acting on ester bonds
  • carboxylic ester hydrolase activity
Processes
  • xenobiotic metabolic process
  • formaldehyde catabolic process
  • glutathione derivative biosynthetic process
  • small molecule metabolic process
Components
  • extracellular exosome
  • endoplasmic reticulum lumen
  • cytoplasmic membrane-bounded vesicle
General FunctionS-formylglutathione hydrolase activity
Specific FunctionSerine hydrolase involved in the detoxification of formaldehyde.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID182265
UniProtKB IDP10768
UniProtKB Entry NameESTD_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019263|S-formylglutathione hydrolase (ESD)
ATGGCATTGAAGCAGATTTCCAGCAACAAGTGCTTTGGGGGATTGCAGAAAGTTTTTGAA
CATGACAGTGTTGAACTAAACTGCAAAATGAAATTTGCTGTCTACTTACCACCAAAGGCA
GAAACAGGAAAGTGCCCTGCACTGTATTGGCTCTCAGGTTTAACTTGCACAGAGCAAAAT
TTTATATCAAAATCTGGTTATCATCAGTCTGCTTCAGAACATGGTCTTGTTGTCATTGCT
CCAGATACCAGCCCTCGTGGCTGCAATATTAAAGGTGAAGATGAGAGCTGGGACTTTGGC
ACTGGTGCTGGATTTTATGTTGATGCCACTGAAGATCCTTGGAAAACCAACTACAGAATG
TACTCTTATGTCACAGAGGAGCTTCCCCAACTCATAAATGCCAATTTTCCAGTGGATCCC
CAAAGGATGTCTATTTTTGGCCACTCCATGGGAGGTCATGGAGCTCTGATCTGTGCTTTG
AAAAATCCTGGAAAATACAAATCTGTGTCAGCATTTGCTCCAATTTGCAACCCTGTACTC
TGTCCCTGGGGCAAAAAAGCCTTTAGTGGATATTTGGGAACAGATCAAAGTAAATGGAAG
GCTTATGATGCTACCCACCTTGTGAAATCCTATCCAGGATCTCAGCTGGACATACTAATT
GATCAAGGGAAAGATGACCAGTTTCTTTTAGATGGACAGTTACTCCCTGATAACTTCATA
GCTGCCTGTACAGAAAAGAAAATCCCCGTTGTTTTTCGATTGCAAGAGGGTTATGATCAT
AGCTACTACTTCATTGCAACCTTTATTACTGACCACATCAGACATCATGCTAAATACCTG
AATGCATGA
GenBank Gene IDM13450
GeneCard IDNot Available
GenAtlas IDESD
HGNC IDHGNC:3465
Chromosome Location13
Locus13q14.1-q14.2
References
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