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NameSolute carrier family 2, facilitated glucose transporter member 4
Synonyms
  • Glucose transporter type 4, insulin-responsive
  • GLUT-4
  • GLUT4
Gene NameSLC2A4
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001780|Solute carrier family 2, facilitated glucose transporter member 4
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETW
LGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAV
LGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAI
VIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPA
RKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQL
SGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGM
CGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAM
AVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQIS
AAFHRTPSLLEQEVKPSTELEYLGPDEND
Number of residues509
Molecular Weight54786.79
Theoretical pI6.94
GO Classification
Functions
  • glucose transmembrane transporter activity
  • D-glucose transmembrane transporter activity
Processes
  • carbohydrate metabolic process
  • cellular response to osmotic stress
  • glucose homeostasis
  • hexose transport
  • glucose transmembrane transport
  • transmembrane transport
  • membrane organization
  • amylopectin biosynthetic process
  • cellular response to insulin stimulus
  • glucose import
  • cellular response to hypoxia
  • response to ethanol
  • brown fat cell differentiation
  • small molecule metabolic process
  • glucose transport
Components
  • insulin-responsive compartment
  • endomembrane system
  • perinuclear region of cytoplasm
  • trans-Golgi network transport vesicle
  • external side of plasma membrane
  • integral component of plasma membrane
  • membrane raft
  • T-tubule
  • membrane
  • plasma membrane
  • coated pit
  • vesicle membrane
  • clathrin-coated vesicle
  • cytosol
  • multivesicular body
  • extracellular exosome
General FunctionGlucose transmembrane transporter activity
Specific FunctionInsulin-regulated facilitative glucose transporter.
Pfam Domain Function
Transmembrane Regions25-45 82-102 112-132 143-163 172-192 202-222 288-308 324-344 354-374 385-405 418-438 446-466
GenBank Protein ID307076
UniProtKB IDP14672
UniProtKB Entry NameGTR4_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0016243|Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)
ATGCCGTCGGGCTTCCAACAGATAGGCTCCGAAGATGGGGAACCCCCTCAGCAGCGAGTG
ACTGGGACCCTGGTCCTTGCTGTGTTCTCTGCGGTGCTTGGCTCCCTGCAGTTTGGGTAC
AACATTGGGGTCATCAATGCCCCTCAGAAGGTGATTGAACAGAGCTACAATGAGACGTGG
CTGGGGAGGCAGGGGCCTGAGGGACCCAGCTCCATCCCTCCAGGCACCCTCACCACCCTC
TGGGCCCTCTCCGTGGCCATCTTTTCCGTGGGCGGCATGATTTCCTCCTTCCTCATTGGT
ATCATCTCTCAGTGGCTTGGAAGGAAAAGGGCCATGCTGGTCAACAATGTCCTGGCGGTG
CTGGGGGGCAGCCTCATGGGCCTGGCCAATGCTGCTGCCTCCTATGAAATGCTCATCCTT
GGACGATTCCTCATTGGCGCCTACTCAGGGCTGACATCAGGGCTGGTGCCCATGTACGTG
GGGGAGATTGCTCCCACTCACCTGCGGGGCGCCCTGGGGACGCTCAACCAACTGGCCATT
GTTATCGGCATTCTGATCGCCCAGGTGCTGGGCTTGGAGTCCCTCCTGGGCACTGCCAGC
CTGTGGCCACTGCTCCTGGGCCTCACAGTGCTACCTGCCCTCCTGCAGCTGGTCCTGCTG
CCCTTCTGTCCCGAGAGCCCCCGCTACCTCTACATCATCCAGAATCTCGAGGGGCCTGCC
AGAAAGAGTCTGAAGCGCCTGACAGGCTGGGCCGATGTTTCTGGAGTGCTGGCTGAGCTG
AAGGATGAGAAGCGGAAGCTGGAGCGTGAGCGGCCACTGTCCCTGCTCCAGCTCCTGGGC
AGCCGTACCCACCGGCAGCCCCTGATCATTGCGGTCGTGCTGCAGCTGAGCCAGCAGCTC
TCTGGCATCAATGCTGTTTTCTATTATTCGACCAGCATCTTCGAGACAGCAGGGGTAGGC
CAGCCTGCCTATGCCACCATAGGAGCTGGTGTGGTCAACACAGTCTTCACCTTGGTCTCG
GTGTTGTTGGTGGAGCGGGCGGGGCGCCGGACGCTCCATCTCCTGGGCCTGGCGGGCATG
TGTGGCTGTGCCATCCTGATGACTGTGGCTCTGCTCCTGCTGGAGCGAGTTCCAGCCATG
AGCTACGTCTCCATTGTGGCCATCTTTGGCTTCGTGGCATTTTTTGAGATTGGCCCTGGC
CCCATTCCTTGGTTCATCGTGGCCGAGCTCTTCAGCCAGGGACCCCGCCCGGCAGCCATG
GCTGTGGCTGGTTTCTCCAACTGGACGAGCAACTTCATCATTGGCATGGGTTTCCAGTAT
GTTGCGGAGGCTATGGGGCCCTACGTCTTCCTTCTATTTGCGGTCCTCCTGCTGGGCTTC
TTCATCTTCACCTTCTTAAGAGTACCTGAAACTCGAGGCCGGACGTTTGACCAGATCTCA
GCTGCCTTCCACCGGACACCCTCTCTTTTAGAGCAGGAGGTGAAACCCAGCACAGAACTT
GAGTATTTAGGGCCAGATGAGAACGACTGA
GenBank Gene IDM20747
GeneCard IDNot Available
GenAtlas IDSLC2A4
HGNC IDHGNC:11009
Chromosome Location17
Locus17p13
References
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  2. Buse JB, Yasuda K, Lay TP, Seo TS, Olson AL, Pessin JE, Karam JH, Seino S, Bell GI: Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation. Diabetes. 1992 Nov;41(11):1436-45. 1397719
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  5. Chiaramonte R, Martini R, Taramelli R, Comi P: Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter. Gene. 1993 Aug 25;130(2):307-8. 7916714
  6. Verhey KJ, Birnbaum MJ: A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts. J Biol Chem. 1994 Jan 28;269(4):2353-6. 8300557
  7. Lalioti VS, Vergarajauregui S, Pulido D, Sandoval IV: The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1. J Biol Chem. 2002 May 31;277(22):19783-91. Epub 2002 Feb 12. 11842083
  8. Lisinski I, Matsumoto H, Yver DR, Schurmann A, Cushman SW, Al-Hasani H: Identification and characterization of p49/STRAP as a novel GLUT4-binding protein. Biochem Biophys Res Commun. 2006 Jun 16;344(4):1179-85. Epub 2006 Apr 21. 16647043
  9. Jeyaraj S, Boehmer C, Lang F, Palmada M: Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4. Biochem Biophys Res Commun. 2007 May 11;356(3):629-35. Epub 2007 Mar 12. 17382906
  10. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. 18669648
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  12. Kusari J, Verma US, Buse JB, Henry RR, Olefsky JM: Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus. J Clin Invest. 1991 Oct;88(4):1323-30. 1918382
  13. Choi WH, O'Rahilly S, Buse JB, Rees A, Morgan R, Flier JS, Moller DE: Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects. Diabetes. 1991 Dec;40(12):1712-8. 1756912
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