NameGlutamine synthetase
Synonyms
  • 6.3.1.2
  • GLNS
  • Glutamate decarboxylase
  • Glutamate--ammonia ligase
  • GS
Gene NameGLUL
OrganismHuman
Amino acid sequence
>lcl|BSEQ0019251|Glutamine synthetase
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEW
NFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRI
MDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHY
RACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDP
KPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRL
TGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCL
LNETGDEPFQYKN
Number of residues373
Molecular Weight42064.15
Theoretical pI6.88
GO Classification
Functions
  • manganese ion binding
  • magnesium ion binding
  • glutamate binding
  • glutamate-ammonia ligase activity
  • glutamate decarboxylase activity
  • identical protein binding
  • ATP binding
Processes
  • response to glucose
  • glutamate catabolic process
  • cell proliferation
  • positive regulation of insulin secretion
  • cellular response to starvation
  • cellular amino acid biosynthetic process
  • positive regulation of synaptic transmission, glutamatergic
  • cellular nitrogen compound metabolic process
  • neurotransmitter uptake
  • small molecule metabolic process
  • glutamine biosynthetic process
  • positive regulation of epithelial cell proliferation
  • protein homooligomerization
  • synaptic transmission
Components
  • rough endoplasmic reticulum
  • glial cell projection
  • cytosol
  • extracellular exosome
  • myelin sheath
  • cytoplasm
  • mitochondrion
  • axon terminus
  • protein complex
  • perikaryon
  • nucleus
General FunctionManganese ion binding
Specific FunctionThis enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID31833
UniProtKB IDP15104
UniProtKB Entry NameGLNA_HUMAN
Cellular LocationCytoplasm
Gene sequence
>lcl|BSEQ0019252|Glutamine synthetase (GLUL)
ATGACCACCTCAGCAAGTTCCCACTTAAATAAAGGCATCAAGCAGGTGTACATGTCCCTG
CCTCAGGGTGAGAAAGTCCAGGCCATGTATATCTGGATCGATGGTACTGGAGAAGGACTG
CGCTGCAAGACCCGGACCCTGGACAGTGAGCCCAAGTGTGTGGAAGAGTTGCCTGAGTGG
AATTTCGATGGCTCTAGTACTTTACAGTCTGAGGGTTCCAACAGTGACATGTATCTCGTG
CCTGCTGCCATGTTTCGGGACCCCTTCCGTAAGGACCCTAACAAGCTGGTGTTATGTGAA
GTTTTCAAGTACAATCGAAGGCCTGCAGAGACCAATTTGAGGCACACCTGTAAACGGATA
ATGGACATGGTGAGCAACCAGCACCCCTGGTTTGGCATGGAGCAGGAGTATACCCTCATG
GGGACAGATGGGCACCCCTTTGGTTGGCCTTCCAACGGCTTCCCAGGGCCCCAGGGTCCA
TATTACTGTGGTGTGGGAGCAGACAGAGCCTATGGCAGGGACATCGTGGAGGCCCATTAC
CGGGCCTGCTTGTATGCTGGAGTCAAGATTGCGGGGACTAATGCCGAGGTCATGCCTGCC
CAGTGGGAATTTCAGATTGGACCTTGTGAAGGAATCAGCATGGGAGATCATCTCTGGGTG
GCCCGTTTCATCTTGCATCGTGTGTGTGAAGACTTTGGAGTGATAGCAACCTTTGATCCT
AAGCCCATTCCTGGGAACTGGAATGGTGCAGGCTGCCATACCAACTTCAGCACCAAGGCC
ATGCGGGAGGAGAATGGTCTGAAGTACATCGAGGAGGCCATTGAGAAACTAAGCAAGCGG
CACCAGTACCACATCCGTGCCTATGATCCCAAGGGAGGCCTGGACAATGCCCGACGTCTA
ACTGGATTCCATGAAACCTCCAACATCAACGACTTTTCTGCTGGTGTAGCCAATCGTAGC
GCCAGCATACGCATTCCCCGGACTGTTGGCCAGGAGAAGAAGGGTTACTTTGAAGATCGT
CGCCCCTCTGCCAACTGCGACCCCTTTTCGGTGACAGAAGCCCTCATCCGCACGTGTCTT
CTCAATGAAACCGGCGATGAGCCCTTCCAGTACAAAAATTAA
GenBank Gene IDY00387
GeneCard IDNot Available
GenAtlas IDGLUL
HGNC IDHGNC:4341
Chromosome Location1
Locus1q31
References
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  2. Van den Hoff MJ, Geerts WJ, Das AT, Moorman AF, Lamers WH: cDNA sequence of the long mRNA for human glutamine synthase. Biochim Biophys Acta. 1991 Oct 8;1090(2):249-51. 1681907
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