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NameVascular endothelial growth factor A
Synonyms
  • Vascular permeability factor
  • VEGF
  • VEGF-A
  • VPF
Gene NameVEGFA
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000325|Vascular endothelial growth factor A
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGGQNHHEVVKFMDVYQRSYCHPIETLVD
IFQEYPDEIEYIFKPSCVPLMRCGGCCNDEGLECVPTEESNITMQIMRIKPHQGQHIGEM
SFLQHNKCECRPKKDRARQEKKSVRGKGKGQKRKRKKSRYKSWSVYVGARCCLMPWSLPG
PHPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR
Number of residues232
Molecular Weight27042.205
Theoretical pI9.08
GO Classification
Functions
  • fibronectin binding
  • vascular endothelial growth factor receptor 1 binding
  • vascular endothelial growth factor receptor binding
  • protein homodimerization activity
  • protein heterodimerization activity
  • chemoattractant activity
  • extracellular matrix binding
  • heparin binding
  • identical protein binding
  • growth factor activity
  • cytokine activity
  • neuropilin binding
  • platelet-derived growth factor receptor binding
  • receptor agonist activity
  • vascular endothelial growth factor receptor 2 binding
Processes
  • artery morphogenesis
  • basophil chemotaxis
  • platelet activation
  • cellular response to hypoxia
  • cell migration involved in sprouting angiogenesis
  • platelet degranulation
  • positive regulation of neuroblast proliferation
  • cardiac vascular smooth muscle cell development
  • lactation
  • positive regulation of angiogenesis
  • commissural neuron axon guidance
  • nervous system development
  • positive regulation of receptor internalization
  • positive regulation of axon extension involved in axon guidance
  • coronary vein morphogenesis
  • in utero embryonic development
  • macrophage differentiation
  • positive regulation of gene expression
  • positive regulation of cell proliferation
  • surfactant homeostasis
  • positive regulation of peptidyl-tyrosine autophosphorylation
  • lymph vessel morphogenesis
  • branching morphogenesis of an epithelial tube
  • patterning of blood vessels
  • positive regulation of mast cell chemotaxis
  • endothelial cell chemotaxis
  • positive regulation of protein kinase D signaling
  • positive regulation of peptidyl-tyrosine phosphorylation
  • positive regulation of CREB transcription factor activity
  • cell maturation
  • camera-type eye morphogenesis
  • kidney development
  • positive regulation of positive chemotaxis
  • coronary artery morphogenesis
  • positive regulation of protein localization to early endosome
  • positive regulation of protein phosphorylation
  • positive regulation of endothelial cell proliferation
  • positive regulation of vascular permeability
  • negative regulation of transcription from RNA polymerase II promoter
  • positive regulation of protein autophosphorylation
  • positive regulation of retinal ganglion cell axon guidance
  • primitive erythrocyte differentiation
  • positive regulation of leukocyte migration
  • positive regulation of focal adhesion assembly
  • angiogenesis
  • positive regulation of p38MAPK cascade
  • regulation of retinal ganglion cell axon guidance
  • ovarian follicle development
  • positive regulation of cell division
  • positive regulation of cellular component movement
  • blood coagulation
  • mammary gland alveolus development
  • regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • positive regulation of cell migration
  • positive regulation of cell adhesion
  • regulation of transcription from RNA polymerase II promoter
  • dopaminergic neuron differentiation
  • positive regulation of MAP kinase activity
  • outflow tract morphogenesis
  • lung development
  • epithelial cell differentiation
  • cellular response to vascular endothelial growth factor stimulus
  • positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
  • regulation of cGMP metabolic process
  • positive regulation of branching involved in ureteric bud morphogenesis
  • negative regulation of apoptotic process
  • heart morphogenesis
  • positive regulation of protein kinase C signaling
  • positive regulation of histone deacetylase activity
  • mesoderm development
  • positive regulation of endothelial cell migration
  • activation of protein kinase activity
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  • positive regulation of mesenchymal cell proliferation
  • vascular endothelial growth factor signaling pathway
  • positive regulation of vascular endothelial growth factor receptor signaling pathway
  • positive regulation of protein complex assembly
  • VEGF-activated neuropilin signaling pathway
  • positive regulation of epithelial cell proliferation
  • positive regulation of blood vessel endothelial cell migration
  • positive regulation of peptidyl-serine phosphorylation
  • monocyte differentiation
  • tube formation
  • growth
  • positive regulation of cell migration involved in sprouting angiogenesis
  • positive regulation of transcription from RNA polymerase II promoter
  • vasculogenesis
  • post-embryonic camera-type eye development
  • regulation of cell shape
  • positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
  • eye photoreceptor cell development
  • response to hypoxia
  • positive chemotaxis
  • induction of positive chemotaxis
  • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
  • positive regulation of ERK1 and ERK2 cascade
  • cardiac muscle fiber development
  • vascular endothelial growth factor receptor signaling pathway
Components
  • platelet alpha granule lumen
  • proteinaceous extracellular matrix
  • cytoplasm
  • secretory granule
  • membrane
  • extracellular region
  • extracellular space
  • cell surface
General FunctionVascular endothelial growth factor receptor binding
Specific FunctionGrowth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID181971
UniProtKB IDP15692
UniProtKB Entry NameVEGFA_HUMAN
Cellular LocationSecreted
Gene sequence
>lcl|BSEQ0021644|Vascular endothelial growth factor A (VEGFA)
CTGACGGACAGACAGACAGACACCGCCCCCAGCCCCAGCTACCACCTCCTCCCCGGCCGG
CGGCGGACAGTGGACGCGGCGGCGAGCCGCGGGCAGGGGCCGGAGCCCGCGCCCGGAGGC
GGGGTGGAGGGGGTCGGGGCTCGCGGCGTCGCACTGAAACTTTTCGTCCAACTTCTGGGC
TGTTCTCGCTTCGGAGGAGCCGTGGTCCGCGCGGGGGAAGCCGAGCCGAGCGGAGCCGCG
AGAAGTGCTAGCTCGGGCCGGGAGGAGCCGCAGCCGGAGGAGGGGGAGGAGGAAGAAGAG
AAGGAAGAGGAGAGGGGGCCGCAGTGGCGACTCGGCGCTCGGAAGCCGGGCTCATGGACG
GGTGAGGCGGCGGTGTGCGCAGACAGTGCTCCAGCCGCGCGCGCTCCCCAGGCCCTGGCC
CGGGCCTCGGGCCGGGGAGGAAGAGTAGCTCGCCGAGGCGCCGAGGAGAGCGGGCCGCCC
CACAGCCCGAGCCGGAGAGGGAGCGCGAGCCGCGCCGGCCCCGGTCGGGCCTCCGAAACC
ATGAACTTTCTGCTGTCTTGGGTGCATTGGAGCCTTGCCTTGCTGCTCTACCTCCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGAGGGCAGAATCATCACGAAGTG
GTGAAGTTCATGGATGTCTATCAGCGCAGCTACTGCCATCCAATCGAGACCCTGGTGGAC
ATCTTCCAGGAGTACCCTGATGAGATCGAGTACATCTTCAAGCCATCCTGTGTGCCCCTG
ATGCGATGCGGGGGCTGCTGCAATGACGAGGGCCTGGAGTGTGTGCCCACTGAGGAGTCC
AACATCACCATGCAGATTATGCGGATCAAACCTCACCAAGGCCAGCACATAGGAGAGATG
AGCTTCCTACAGCACAACAAATGTGAATGCAGACCAAAGAAAGATAGAGCAAGACAAGAA
AAAAAATCAGTTCGAGGAAAGGGAAAGGGGCAAAAACGAAAGCGCAAGAAATCCCGGTAT
AAGTCCTGGAGCGTGTACGTTGGTGCCCGCTGCTGTCTAATGCCCTGGAGCCTCCCTGGC
CCCCATCCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAG
ACGTGTAAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTA
AACGAACGTACTTGCAGATGTGACAAGCCGAGGCGGTGA
GenBank Gene IDM32977
GeneCard IDNot Available
GenAtlas IDVEGF
HGNC IDHGNC:12680
Chromosome Location6
Locus6p12
References
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