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Histone H2AX

NameHistone H2AX
Synonyms
  • H2a/x
  • H2AX
  • Histone H2A.X
Gene NameH2AFX
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013494|Histone H2AX
MSGRGKTGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGHYAERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGGVTIAQGGVLPNIQAVLLPKK
TSATVGPKAPSGGKKATQASQEY
Number of residues143
Molecular Weight15144.45
Theoretical pINot Available
GO Classification
Functions
  • histone binding
  • DNA binding
  • enzyme binding
  • damaged DNA binding
Processes
  • DNA damage checkpoint
  • cellular response to DNA damage stimulus
  • meiotic cell cycle
  • double-strand break repair
  • cellular response to gamma radiation
  • double-strand break repair via homologous recombination
  • double-strand break repair via nonhomologous end joining
  • nucleosome assembly
  • response to ionizing radiation
  • spermatogenesis
  • viral process
  • cerebral cortex development
  • DNA repair
  • chromatin organization
  • positive regulation of DNA repair
  • cellular senescence
  • chromatin silencing
Components
  • extracellular exosome
  • condensed nuclear chromosome
  • nucleoplasm
  • male germ cell nucleus
  • nucleosome
  • nuclear chromatin
  • site of double-strand break
  • XY body
  • nucleus
  • replication fork
General FunctionHistone binding
Specific FunctionVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP16104
UniProtKB Entry NameH2AX_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013495|Histone H2AX (H2AFX)
ATGTCGGGCCGCGGCAAGACTGGCGGCAAGGCCCGCGCCAAGGCCAAGTCGCGCTCGTCG
CGCGCCGGCCTCCAGTTCCCAGTGGGCCGTGTACACCGGCTGCTGCGGAAGGGCCACTAC
GCCGAGCGCGTTGGCGCCGGCGCGCCAGTGTACCTGGCGGCAGTGCTGGAGTACCTCACC
GCTGAGATCCTGGAGCTGGCGGGCAATGCGGCCCGCGACAACAAGAAGACGCGAATCATC
CCCCGCCACCTGCAGCTGGCCATCCGCAACGACGAGGAGCTCAACAAGCTGCTGGGCGGC
GTGACGATCGCCCAGGGAGGCGTCCTGCCCAACATCCAGGCCGTGCTGCTGCCCAAGAAG
ACCAGCGCCACCGTGGGGCCGAAGGCGCCCTCGGGCGGCAAGAAGGCCACCCAGGCCTCC
CAGGAGTACTAA
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4739
Chromosome Location11
LocusNot Available
References
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  29. Jha HC, A J MP, Saha A, Banerjee S, Lu J, Robertson ES: Epstein-Barr virus essential antigen EBNA3C attenuates H2AX expression. J Virol. 2014 Apr;88(7):3776-88. doi: 10.1128/JVI.03568-13. Epub 2014 Jan 15. 24429368
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