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NameCyclic AMP-responsive element-binding protein 1
Synonyms
  • CREB-1
Gene NameCREB1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001907|Cyclic AMP-responsive element-binding protein 1
MTMESGAENQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPN
GQTVQVHGVIQAAQPSVIQSPQVQTVQSSCKDLKRLFSGTQISTIAESEDSQESVDSVTD
SQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSG
QYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQV
VVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAAREC
RRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Number of residues341
Molecular Weight36687.86
Theoretical pI5.24
GO Classification
Functions
  • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
  • transcriptional activator activity, RNA polymerase II transcription factor binding
  • cAMP response element binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II activating transcription factor binding
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
  • enzyme binding
  • RNA polymerase II distal enhancer sequence-specific DNA binding
  • transcription cofactor activity
  • transcription factor activity, sequence-specific DNA binding
Processes
  • Type I pneumocyte differentiation
  • axon guidance
  • toll-like receptor 3 signaling pathway
  • Notch signaling pathway
  • epidermal growth factor receptor signaling pathway
  • toll-like receptor 4 signaling pathway
  • pituitary gland development
  • innate immune response
  • toll-like receptor 5 signaling pathway
  • positive regulation of multicellular organism growth
  • Fc-epsilon receptor signaling pathway
  • toll-like receptor 9 signaling pathway
  • toll-like receptor signaling pathway
  • viral process
  • cellular response to zinc ion
  • positive regulation of transcription, DNA-templated
  • toll-like receptor TLR1
  • regulation of circadian rhythm
  • fibroblast growth factor receptor signaling pathway
  • toll-like receptor TLR6
  • response to organic substance
  • positive regulation of hormone secretion
  • neurotrophin TRK receptor signaling pathway
  • TRIF-dependent toll-like receptor signaling pathway
  • signal transduction
  • response to glucagon
  • negative regulation of transcription by competitive promoter binding
  • positive regulation of transcription from RNA polymerase II promoter
  • protein phosphorylation
  • lung saccule development
  • circadian rhythm
  • response to drug
  • secretory granule organization
  • positive regulation of fat cell differentiation
  • protein stabilization
  • synaptic transmission
  • positive regulation of osteoclast differentiation
  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
  • activation of phospholipase C activity
  • positive regulation of lipid biosynthetic process
  • MyD88-dependent toll-like receptor signaling pathway
  • regulation of cell size
  • phosphatidylinositol-mediated signaling
  • lactation
  • MyD88-independent toll-like receptor signaling pathway
  • memory
  • stress-activated MAPK cascade
  • positive regulation of transforming growth factor beta3 production
  • transforming growth factor beta receptor signaling pathway
  • regulation of apoptotic process
  • toll-like receptor 10 signaling pathway
  • toll-like receptor 2 signaling pathway
Components
  • mitochondrion
  • nuclear euchromatin
  • nucleus
  • ATF4-CREB1 transcription factor complex
  • nucleoplasm
General FunctionTranscriptional activator activity, rna polymerase ii transcription factor binding
Specific FunctionPhosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID240429
UniProtKB IDP16220
UniProtKB Entry NameCREB1_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0021836|Cyclic AMP-responsive element-binding protein 1 (CREB1)
ATGACCATGGAATCTGGAGCCGAGAACCAGCAGAGTGGAGATGCAGCTGTAACAGAAGCT
GAAAACCAACAAATGACAGTTCAAGCCCAGCCACAGATTGCCACATTAGCCCAGGTATCT
ATGCCAGCAGCTCATGCAACATCATCTGCTCCCACCGTAACTCTAGTACAGCTGCCCAAT
GGGCAGACAGTTCAAGTCCATGGAGTCATTCAGGCGGCCCAGCCATCAGTTATTCAGTCT
CCACAAGTCCAAACAGTTCAGATTTCAACTATTGCAGAAAGTGAAGATTCACAGGAGTCA
GTGGATAGTGTAACTGATTCCCAAAAGCGAAGGGAAATTCTTTCAAGGAGGCCTTCCTAC
AGGAAAATTTTGAATGACTTATCTTCTGATGCACCAGGAGTGCCAAGGATTGAAGAAGAG
AAGTCTGAAGAGGAGACTTCAGCACCTGCCATCACCACTGTAACGGTGCCAACTCCAATT
TACCAAACTAGCAGTGGACAGTATATTGCCATTACCCAGGGAGGAGCAATACAGCTGGCT
AACAATGGTACCGATGGGGTACAGGGCCTGCAAACATTAACCATGACCAATGCAGCAGCC
ACTCAGCCGGGTACTACCATTCTACAGTATGCACAGACCACTGATGGACAGCAGATCTTA
GTGCCCAGCAACCAAGTTGTTGTTCAAGCTGCCTCTGGAGACGTACAAACATACCAGATT
CGCACAGCACCCACTAGCACTATTGCCCCTGGAGTTGTTATGGCATCCTCCCCAGCACTT
CCTACACAGCCTGCTGAAGAAGCAGCACGAAAGAGAGAGGTCCGTCTAATGAAGAACAGG
GAAGCAGCTCGAGAGTGTCGTAGAAAGAAGAAAGAATATGTGAAATGTTTAGAAAACAGA
GTGGCAGTGCTTGAAAATCAAAACAAGACATTGATTGAGGAGCTAAAAGCACTTAAGGAC
CTTTACTGCCACAAATCAGATTAA
GenBank Gene IDS72459
GeneCard IDNot Available
GenAtlas IDCREB1
HGNC IDHGNC:2345
Chromosome Location2
Locus2q34
References
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  2. Yoshimura T, Fujisawa J, Yoshida M: Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. EMBO J. 1990 Aug;9(8):2537-42. 2196176
  3. Waeber G, Meyer TE, Hoeffler JP, Habener JF: Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing. Trans Assoc Am Physicians. 1990;103:28-37. 1966745
  4. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF: Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science. 1988 Dec 9;242(4884):1430-3. 2974179
  5. Short ML, Manohar CF, Furtado MR, Ghadge GD, Wolinsky SM, Thimmapaya B, Jungmann RA: Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. Nucleic Acids Res. 1991 Aug 11;19(15):4290. 1831258
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  8. Meyer TE, Waeber G, Lin J, Beckmann W, Habener JF: The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. Endocrinology. 1993 Feb;132(2):770-80. 8381074
  9. Maguire HF, Hoeffler JP, Siddiqui A: HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. Science. 1991 May 10;252(5007):842-4. 1827531
  10. Zhao LJ, Giam CZ: Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7070-4. 1386673
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  12. Lee HJ, Mignacca RC, Sakamoto KM: Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. J Biol Chem. 1995 Jul 7;270(27):15979-83. 7608156
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