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NameHistone H1.2
Synonyms
  • H1F2
  • Histone H1c
  • Histone H1d
  • Histone H1s-1
Gene NameHIST1H1C
OrganismHuman
Amino acid sequence
>lcl|BSEQ0013479|Histone H1.2
MSETAPAAPAAAPPAEKAPVKKKAAKKAGGTPRKASGPPVSELITKAVAASKERSGVSLA
ALKKALAAAGYDVEKNNSRIKLGLKSLVSKGTLVQTKGTGASGSFKLNKKAASGEAKPKV
KKAGGTKPKKPVGAAKKPKKAAGGATPKKSAKKTPKKAKKPAAATVTKKVAKSPKKAKVA
KPKKAAKSAAKAVKPKAAKPKVVKPKKAAPKKK
Number of residues213
Molecular Weight21364.57
Theoretical pINot Available
GO Classification
Functions
  • chromatin DNA binding
  • poly(A) RNA binding
Processes
  • negative regulation of transcription from RNA polymerase II promoter
  • nucleosome assembly
  • nucleosome positioning
Components
  • nucleus
  • nuclear euchromatin
  • nucleosome
  • transcriptionally active chromatin
General FunctionPoly(a) rna binding
Specific FunctionHistone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity).
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein IDNot Available
UniProtKB IDP16403
UniProtKB Entry NameH12_HUMAN
Cellular LocationNucleus
Gene sequence
>lcl|BSEQ0013480|Histone H1.2 (HIST1H1C)
ATGTCCGAGACTGCTCCTGCCGCTCCCGCTGCCGCGCCTCCTGCGGAGAAGGCCCCTGTA
AAGAAGAAGGCGGCCAAAAAGGCTGGGGGTACGCCTCGTAAGGCGTCTGGTCCCCCGGTG
TCAGAGCTCATCACCAAGGCTGTGGCCGCCTCTAAAGAGCGTAGCGGAGTTTCTCTGGCT
GCTCTGAAAAAAGCGTTGGCTGCCGCCGGCTATGATGTGGAGAAAAACAACAGCCGTATC
AAACTTGGTCTCAAGAGCCTGGTGAGCAAGGGCACTCTGGTGCAAACGAAAGGCACCGGT
GCTTCTGGCTCCTTTAAACTCAACAAGAAGGCAGCCTCCGGGGAAGCCAAGCCCAAGGTT
AAAAAGGCGGGCGGAACCAAACCTAAGAAGCCAGTTGGGGCAGCCAAGAAGCCCAAGAAG
GCGGCTGGCGGCGCAACTCCGAAGAAGAGCGCTAAGAAAACACCGAAGAAAGCGAAGAAG
CCGGCCGCGGCCACTGTAACCAAGAAAGTGGCTAAGAGCCCAAAGAAGGCCAAGGTTGCG
AAGCCCAAGAAAGCTGCCAAAAGTGCTGCTAAGGCTGTGAAGCCCAAGGCCGCTAAGCCC
AAGGTTGTCAAGCCTAAGAAGGCGGCGCCCAAGAAGAAATAG
GenBank Gene IDNot Available
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:4716
Chromosome Location6
LocusNot Available
References
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