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NameCTP synthase 1
Synonyms
  • 6.3.4.2
  • CTP synthetase 1
  • CTPS
  • UTP--ammonia ligase 1
Gene NameCTPS1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0001742|CTP synthase 1
MKYILVTGGVISGIGKGIIASSVGTILKSCGLHVTSIKIDPYINIDAGTFSPYEHGEVFV
LDDGGEVDLDLGNYERFLDIRLTKDNNLTTGKIYQYVINKERKGDYLGKTVQVVPHITDA
IQEWVMRQALIPVDEDGLEPQVCVIELGGTVGDIESMPFIEAFRQFQFKVKRENFCNIHV
SLVPQPSSTGEQKTKPTQNSVRELRGLGLSPDLVVCRCSNPLDTSVKEKISMFCHVEPEQ
VICVHDVSSIYRVPLLLEEQGVVDYFLRRLDLPIERQPRKMLMKWKEMADRYDRLLETCS
IALVGKYTKFSDSYASVIKALEHSALAINHKLEIKYIDSADLEPITSQEEPVRYHEAWQK
LCSAHGVLVPGGFGVRGTEGKIQAIAWARNQKKPFLGVCLGMQLAVVEFSRNVLGWQDAN
STEFDPTTSHPVVVDMPEHNPGQMGGTMRLGKRRTLFQTKNSVMRKLYGDADYLEERHRH
RFEVNPVWKKCLEEQGLKFVGQDVEGERMEIVELEDHPFFVGVQYHPEFLSRPIKPSPPY
FGLLLASVGRLSHYLQKGCRLSPRDTYSDRSGSSSPDSEITELKFPSINHD
Number of residues591
Molecular Weight66689.9
Theoretical pI6.42
GO Classification
Functions
  • ATP binding
  • CTP synthase activity
Processes
  • nucleobase-containing small molecule metabolic process
  • glutamine metabolic process
  • nucleobase-containing compound metabolic process
  • nucleobase-containing small molecule interconversion
  • CTP biosynthetic process
  • 'de novo' CTP biosynthetic process
  • T cell proliferation
  • response to drug
  • small molecule metabolic process
  • B cell proliferation
Components
  • membrane
  • cytosol
General FunctionCtp synthase activity
Specific FunctionThis enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity.
Pfam Domain Function
Transmembrane RegionsNot Available
GenBank Protein ID30293
UniProtKB IDP17812
UniProtKB Entry NamePYRG1_HUMAN
Cellular LocationNot Available
Gene sequence
>lcl|BSEQ0019024|CTP synthase 1 (CTPS1)
ATGCCCTTTATTGAGGCCTTCCGTCAGTTCCAATTCAAGGTCAAAAGAGAGAACTTTTGT
AACATCCACGTCAGTCTAGTTCCCCAGCCAAGTTCAACAGGGGAACAGAAGACTAAACCT
ACCCAGAATAGTGTTCGGGAACTTAGAGGACTTGGGCTTTCCCCAGATCTGGTTGTATGC
AGGTGCTCAAATCCACTTGACACATCAGTGAAGGAGAAAATATCAATGTTCTGCCATGTT
GAGCCTGAACAAGTGATCTGTGTCCACGATGTCTCATCCATCTACCGAGTCCCCTTGTTG
TTAGAGGAGCAAGGGGTTGTAGATTATTTTCTTCGAAGACTTGACCTTCCTATTGAGAGG
CAGCCAAGAAAAATGCTGATGAAATGGAAAGAGATGGCTGACAGATATGATCGCTTGCTG
GAGACCTGCTCTATTGCCCTTGTGGGCAAATACACGAAGTTCTCAGACTCCTATGCCTCT
GTCATTAAGGCTCTGGAGCATTCTGCACTGGCCATCAACCACAAATTGGAAATCAAGTAC
ATAGATTCTGCGGACTTGGAGCCCATCACCTCGCAAGAAGAGCCCGTGCGCTACCACGAA
GCTTGGCAGAAGCTCTGTAGTGCTCATGGAGTGCTGGTTCCAGGAGGATTTGGTGTTCGA
GGAACAGAAGGAAAAATCCAAGCAATTGCCTGGGCTCGGAATCAGAAAAAGCCTTTTTTG
GGCGTGTGCTTAGGGATGCAGTTGGCAGTGGTTGAATTCTCAAGAAACGTGCTGGGATGG
CAAGATGCCAATTCTACAGAGTTTGACCCTACGACCAGTCATCCCGTGGTCGTAGACATG
CCAGAACACAACCCAGGGCAGATGGGCGGAACCATGAGGCTGGGCAAGAGGAGAACCCTG
TTCCAGACCAAGAACTCAGTCATGAGGAAACTCTATGGAGACGCAGACTACTTGGAAGAG
AGGCACCGCCACCGATTTGAGGTGAATCCAGTCTGGAAAAAGTGTTTGGAAGAACAAGGC
TTGAAGTTTGTTGGCCAAGATGTTGAAGGAGAGAGAATGGAAATTGTGGAGTTAGAAGAT
CATCCCTTTTTTGTTGGGGTTCAGTACCACCCTGAGTTCCTGTCCAGGCCTATCAAGCCC
TCCCCACCATACTTTGGCCTCCTCCTGGCCTCTGTGGGGCGGCTCTCACATTACCTCCAG
AAAGGCTGCAGGCTCTCACCCAGGGACACCTATAGTGACAGGAGTGGAAGCAGCTCCCCT
GACTCTGAAATCACCGAACTGAAGTTTCCATCAATAAATCATGACTGA
GenBank Gene IDX52142
GeneCard IDNot Available
GenAtlas IDCTPS
HGNC IDHGNC:2519
Chromosome Location1
Locus1p34.1
References
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