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NameCannabinoid receptor 1
Synonyms
  • CANN6
  • CB-R
  • CNR
Gene NameCNR1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0000122|Cannabinoid receptor 1
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Number of residues472
Molecular Weight52857.365
Theoretical pI8.25
GO Classification
Functions
  • drug binding
  • cannabinoid receptor activity
Processes
  • glucose homeostasis
  • regulation of penile erection
  • memory
  • positive regulation of apoptotic process
  • regulation of synaptic transmission, GABAergic
  • response to nutrient
  • regulation of synaptic transmission, glutamatergic
  • response to ethanol
  • response to morphine
  • aging
  • regulation of insulin secretion
  • spermatogenesis
  • maternal process involved in female pregnancy
  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • response to nicotine
  • cannabinoid signaling pathway
  • positive regulation of blood pressure
  • negative regulation of action potential
  • negative regulation of mast cell activation
  • axonal fasciculation
  • negative regulation of nitric-oxide synthase activity
  • negative regulation of dopamine secretion
  • response to lipopolysaccharide
  • negative regulation of fatty acid beta-oxidation
  • positive regulation of acute inflammatory response to antigenic stimulus
  • sensory perception of pain
  • positive regulation of fever generation
  • negative regulation of blood pressure
  • positive regulation of neuron projection development
  • response to cocaine
  • regulation of feeding behavior
Components
  • integral component of plasma membrane
  • intracellular membrane-bounded organelle
  • membrane raft
  • axon
  • growth cone
  • plasma membrane
General FunctionDrug binding
Specific FunctionInvolved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Pfam Domain Function
Transmembrane Regions117-142 155-175 188-212 233-255 274-299 345-365 378-399
GenBank Protein ID29915
UniProtKB IDP21554
UniProtKB Entry NameCNR1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0010146|Cannabinoid receptor 1 (CNR1)
ATGAAGTCGATCCTAGATGGCCTTGCAGATACCACCTTCCGCACCATCACCACTGACCTC
CTGTACGTGGGCTCAAATGACATTCAGTACGAAGACATCAAAGGTGACATGGCATCCAAA
TTAGGGTACTTCCCACAGAAATTCCCTTTAACTTCCTTTAGGGGAAGTCCCTTCCAAGAG
AAGATGACTGCGGGAGACAACCCCCAGCTAGTCCCAGCAGACCAGGTGAACATTACAGAA
TTTTACAACAAGTCTCTCTCGTCCTTCAAGGAGAATGAGGAGAACATCCAGTGTGGGGAG
AACTTCATGGACATAGAGTGTTTCATGGTCCTGAACCCCAGCCAGCAGCTGGCCATTGCA
GTCCTGTCCCTCACGCTGGGCACCTTCACGGTCCTGGAGAACCTCCTGGTGCTGTGCGTC
ATCCTCCACTCCCGCAGCCTCCGCTGCAGGCCTTCCTACCACTTCATCGGCAGCCTGGCG
GTGGCAGACCTCCTGGGGAGTGTCATTTTTGTCTACAGCTTCATTGACTTCCACGTGTTC
CACCGCAAAGATAGCCGCAACGTGTTTCTGTTCAAACTGGGTGGGGTCACGGCCTCCTTC
ACTGCCTCCGTGGGCAGCCTGTTCCTCACAGCCATCGACAGGTACATATCCATTCACAGG
CCCCTGGCCTATAAGAGGATTGTCACCAGGCCCAAGGCCGTGGTGGCGTTTTGCCTGATG
TGGACCATAGCCATTGTGATCGCCGTGCTGCCTCTCCTGGGCTGGAACTGCGAGAAACTG
CAATCTGTTTGCTCAGACATTTTCCCACACATTGATGAAACCTACCTGATGTTCTGGATC
GGGGTCACCAGCGTACTGCTTCTGTTCATCGTGTATGCGTACATGTATATTCTCTGGAAG
GCTCACAGCCACGCCGTCCGCATGATTCAGCGTGGCACCCAGAAGAGCATCATCATCCAC
ACGTCTGAGGATGGGAAGGTACAGGTGACCCGGCCAGACCAAGCCCGCATGGACATTAGG
TTAGCCAAGACCCTGGTCCTGATCCTGGTGGTGTTGATCATCTGCTGGGGCCCTCTGCTT
GCAATCATGGTGTATGATGTCTTTGGGAAGATGAACAAGCTCATTAAGACGGTGTTTGCA
TTCTGCAGTATGCTCTGCCTGCTGAACTCCACCGTGAACCCCATCATCTATGCTCTGAGG
AGTAAGGACCTGCGACACGCTTTCCGGAGCATGTTTCCCTCTTGTGAAGGCACTGCGCAG
CCTCTGGATAACAGCATGGGGGACTCGGACTGCCTGCACAAACACGCAAACAATGCAGCC
AGTGTTCACAGGGCCGCAGAAAGCTGCATCAAGAGCACGGTCAAGATTGCCAAGGTAACC
ATGTCTGTGTCCACAGACACGTCTGCCGAGGCTCTGTGA
GenBank Gene IDX54937
GeneCard IDNot Available
GenAtlas IDCNR1
HGNC IDHGNC:2159
Chromosome Location6
Locus6q14-q15
References
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  2. Gerard CM, Mollereau C, Vassart G, Parmentier M: Molecular cloning of a human cannabinoid receptor which is also expressed in testis. Biochem J. 1991 Oct 1;279 ( Pt 1):129-34. 1718258
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