Tmic
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NameD(1A) dopamine receptor
Synonyms
  • Dopamine D1 receptor
Gene NameDRD1
OrganismHuman
Amino acid sequence
>lcl|BSEQ0021252|D(1A) dopamine receptor
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
Number of residues446
Molecular Weight49292.765
Theoretical pI8.34
GO Classification
Functions
  • dopamine neurotransmitter receptor activity, coupled via Gs
  • G-protein coupled amine receptor activity
  • drug binding
  • dopamine binding
  • dopamine neurotransmitter receptor activity
Processes
  • response to morphine
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
  • vasodilation
  • social behavior
  • dentate gyrus development
  • behavioral response to cocaine
  • positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
  • sensory perception of chemical stimulus
  • neuronal action potential
  • habituation
  • synapse assembly
  • adenylate cyclase-activating dopamine receptor signaling pathway
  • positive regulation of membrane potential
  • transmission of nerve impulse
  • positive regulation of release of sequestered calcium ion into cytosol
  • positive regulation of long-term synaptic potentiation
  • behavioral fear response
  • cellular response to insulin stimulus
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • positive regulation of feeding behavior
  • regulation of vasoconstriction
  • calcium-mediated signaling
  • cellular response to hypoxia
  • regulation of dopamine metabolic process
  • dopamine transport
  • cellular response to catecholamine stimulus
  • peristalsis
  • negative regulation of protein kinase activity
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
  • memory
  • long-term synaptic potentiation
  • positive regulation of cAMP biosynthetic process
  • learning
  • operant conditioning
  • response to retinoic acid
  • dopamine metabolic process
  • response to amino acid
  • negative regulation of circadian sleep/wake cycle, sleep
  • mating behavior
  • response to food
  • long term synaptic depression
  • regulation of long-term neuronal synaptic plasticity
  • regulation of dopamine uptake involved in synaptic transmission
  • grooming behavior
  • negative regulation of cell migration
  • positive regulation of potassium ion transport
  • prepulse inhibition
  • phospholipase C-activating dopamine receptor signaling pathway
  • astrocyte development
  • response to antidepressant
  • response to amphetamine
  • response to ethanol
  • temperature homeostasis
  • orbitofrontal cortex development
  • positive regulation of cell migration
  • sensitization
  • protein import into nucleus
  • striatum development
  • response to nicotine
  • adult walking behavior
  • positive regulation of synaptic transmission, glutamatergic
  • response to estradiol
  • synaptic transmission, dopaminergic
  • glucose import
  • response to activity
  • visual learning
  • conditioned taste aversion
  • response to drug
  • activation of adenylate cyclase activity
  • maternal behavior
  • cerebral cortex GABAergic interneuron migration
Components
  • plasma membrane
  • axon terminus
  • dendritic shaft
  • endoplasmic reticulum membrane
  • caveola
  • neuronal cell body
  • dendritic spine head
  • dendritic spine neck
  • cytosol
  • ciliary membrane
  • integral component of plasma membrane
  • nonmotile primary cilium
  • nucleus
General FunctionG-protein coupled amine receptor activity
Specific FunctionDopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.
Pfam Domain Function
Transmembrane Regions24-49 61-87 97-119 139-163 193-218 273-299 313-337
GenBank Protein ID30397
UniProtKB IDP21728
UniProtKB Entry NameDRD1_HUMAN
Cellular LocationCell membrane
Gene sequence
>lcl|BSEQ0021253|D(1A) dopamine receptor (DRD1)
ATGAGGACTCTGAACACCTCTGCCATGGACGGGACTGGGCTGGTGGTGGAGAGGGACTTC
TCTGTTCGTATCCTCACTGCCTGTTTCCTGTCGCTGCTCATCCTGTCCACGCTCCTGGGG
AACACGCTGGTCTGTGCTGCCGTTATCAGGTTCCGACACCTGCGGTCCAAGGTGACCAAC
TTCTTTGTCATCTCCTTGGCTGTGTCAGATCTCTTGGTGGCCGTCCTGGTCATGCCCTGG
AAGGCAGTGGCTGAGATTGCTGGCTTCTGGCCCTTTGGGTCCTTCTGTAACATCTGGGTG
GCCTTTGACATCATGTGCTCCACTGCATCCATCCTCAACCTCTGTGTGATCAGCGTGGAC
AGGTATTGGGCTATCTCCAGCCCTTTCCGGTATGAGAGAAAGATGACCCCCAAGGCAGCC
TTCATCCTGATCAGTGTGGCATGGACCTTGTCTGTACTCATCTCCTTCATCCCAGTGCAG
CTCAGCTGGCACAAGGCAAAACCCACAAGCCCCTCTGATGGAAATGCCACTTCCCTGGCT
GAGACCATAGACAACTGTGACTCCAGCCTCAGCAGGACATATGCCATCTCATCCTCTGTA
ATAAGCTTTTACATCCCTGTGGCCATCATGATTGTCACCTACACCAGGATCTACAGGATT
GCTCAGAAACAAATACGGCGCATTGCGGCCTTGGAGAGGGCAGCAGTCCACGCCAAGAAT
TGCCAGACCACCACAGGTAATGGAAAGCCTGTCGAATGTTCTCAACCGGAAAGTTCTTTT
AAGATGTCCTTCAAAAGAGAAACTAAAGTCCTGAAGACTCTGTCGGTGATCATGGGTGTG
TTTGTGTGCTGTTGGCTACCTTTCTTCATCTTGAACTGCATTTTGCCCTTCTGTGGGTCT
GGGGAGACGCAGCCCTTCTGCATTGATTCCAACACCTTTGACGTGTTTGTGTGGTTTGGG
TGGGCTAATTCATCCTTGAACCCCATCATTTATGCCTTTAATGCTGATTTTCGGAAGGCA
TTTTCAACCCTCTTAGGATGCTACAGACTTTGCCCTGCGACGAATAATGCCATAGAGACG
GTGAGTATCAATAACAATGGGGCCGCGATGTTTTCCAGCCATCATGAGCCACGAGGCTCC
ATCTCCAAGGAGTGCAATCTGGTTTACCTGATCCCACATGCTGTGGGCTCCTCTGAGGAC
CTGAAAAAGGAGGAGGCAGCTGGCATCGCCAGACCCTTGGAGAAGCTGTCCCCAGCCCTA
TCAGTCATATTGGACTATGACACTGACGTCTCTCTGGAGAAGATCCAACCCATCACACAA
AACGGTCAGCACCCAACCTGA
GenBank Gene IDX55760
GeneCard IDNot Available
GenAtlas IDDRD1
HGNC IDHGNC:3020
Chromosome Location5
Locus5q35.1
References
  1. Dearry A, Gingrich JA, Falardeau P, Fremeau RT Jr, Bates MD, Caron MG: Molecular cloning and expression of the gene for a human D1 dopamine receptor. Nature. 1990 Sep 6;347(6288):72-6. 2144334
  2. Zhou QY, Grandy DK, Thambi L, Kushner JA, Van Tol HH, Cone R, Pribnow D, Salon J, Bunzow JR, Civelli O: Cloning and expression of human and rat D1 dopamine receptors. Nature. 1990 Sep 6;347(6288):76-80. 2168520
  3. Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL, Israel Y, et al.: Human dopamine D1 receptor encoded by an intronless gene on chromosome 5. Nature. 1990 Sep 6;347(6288):80-3. 1975640
  4. Ohara K, Ulpian C, Seeman P, Sunahara RK, Van Tol HH, Niznik HB: Schizophrenia: dopamine D1 receptor sequence is normal, but has DNA polymorphisms. Neuropsychopharmacology. 1993 Feb;8(2):131-5. 8471124
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