T3DB: Receptor-type tyrosine-protein phosphatase beta

Name	Receptor-type tyrosine-protein phosphatase beta
Synonyms	3.1.3.48 Protein-tyrosine phosphatase beta PTPB Vascular endothelial protein tyrosine phosphatase VE-PTP
Gene Name	PTPRB
Organism	Human
Amino acid sequence	>lcl\|BSEQ0037258\|Receptor-type tyrosine-protein phosphatase beta MLSHGAGLALWITLSLLQTGLAEPERCNFTLAESKASSHSVSIQWRILGSPCNFSLIYSS DTLGAALCPTFRIDNTTYGCNLQDLQAGTIYNFRIISLDEERTVVLQTDPLPPARFGVSK EKTTSTSLHVWWTPSSGKVTSYEVQLFDENNQKIQGVQIQESTSWNEYTFFNLTAGSKYN IAITAVSGGKRSFSVYTNGSTVPSPVKDIGISTKANSLLISWSHGSGNVERYRLMLMDKG ILVHGGVVDKHATSYAFHGLTPGYLYNLTVMTEAAGLQNYRWKLVRTAPMEVSNLKVTND GSLTSLKVKWQRPPGNVDSYNITLSHKGTIKESRVLAPWITETHFKELVPGRLYQVTVSC VSGELSAQKMAVGRTFPDKVANLEANNNGRMRSLVVSWSPPAGDWEQYRILLFNDSVVLL NITVGKEETQYVMDDTGLVPGRQYEVEVIVESGNLKNSERCQGRTVPLAVLQLRVKHANE TSLSIMWQTPVAEWEKYIISLADRDLLLIHKSLSKDAKEFTFTDLVPGRKYMATVTSISG DLKNSSSVKGRTVPAQVTDLHVANQGMTSSLFTNWTQAQGDVEFYQVLLIHENVVIKNES ISSETSRYSFHSLKSGSLYSVVVTTVSGGISSRQVVVEGRTVPSSVSGVTVNNSGRNDYL SVSWLLAPGDVDNYEVTLSHDGKVVQSLVIAKSVRECSFSSLTPGRLYTVTITTRSGKYE NHSFSQERTVPDKVQGVSVSNSARSDYLRVSWVHATGDFDHYEVTIKNKNNFIQTKSIPK SENECVFVQLVPGRLYSVTVTTKSGQYEANEQGNGRTIPEPVKDLTLRNRSTEDLHVTWS GANGDVDQYEIQLLFNDMKVFPPFHLVNTATEYRFTSLTPGRQYKILVLTISGDVQQSAF IEGFTVPSAVKNIHISPNGATDSLTVNWTPGGGDVDSYTVSAFRHSQKVDSQTIPKHVFE HTFHRLEAGEQYQIMIASVSGSLKNQINVVGRTVPASVQGVIADNAYSSYSLIVSWQKAA GVAERYDILLLTENGILLRNTSEPATTKQHKFEDLTPGKKYKIQILTVSGGLFSKEAQTE GRTVPAAVTDLRITENSTRHLSFRWTASEGELSWYNIFLYNPDGNLQERAQVDPLVQSFS FQNLLQGRMYKMVIVTHSGELSNESFIFGRTVPASVSHLRGSNRNTTDSLWFNWSPASGD FDFYELILYNPNGTKKENWKDKDLTEWRFQGLVPGRKYVLWVVTHSGDLSNKVTAESRTA PSPPSLMSFADIANTSLAITWKGPPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVY GLRPGRSYQFNVKTVSGDSWKTYSKPIFGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDS DFDGYSIECRKMDTQEVEFSRKLEKEKSLLNIMMLVPHKRYLVSIKVQSAGMTSEVVEDS TITMIDRPPPPPPHIRVNEKDVLISKSSINFTVNCSWFSDTNGAVKYFTVVVREADGSDE LKPEQQHPLPSYLEYRHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCD PTQQKFCDGPLKPHTAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSLPITTESEPLFGAI EGVSAGLFLIGMLVAVVALLICRQKVSHGRERPSARLSIRRDRPLSVHLNLGQKGNRKTS CPIKINQFEGHFMKLQADSNYLLSKEYEELKDVGRNQSCDIALLPENRGKNRYNNILPYD ATRVKLSNVDDDPCSDYINASYIPGNNFRREYIVTQGPLPGTKDDFWKMVWEQNVHNIVM VTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSESVLPEWTIREFKICGEEQLDAHRLI RHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPGAGPTVVHCSAGVGRTGTFIALDRI LQQLDSKDSVDIYGAVHDLRLHRVHMVQTECQYVYLHQCVRDVLRARKLRSEQENPLFPI YENVNPEYHRDPVYSRH
Number of residues	1997
Molecular Weight	224299.74
Theoretical pI	7.72
GO Classification	Functions transmembrane receptor protein tyrosine phosphatase activity Processes angiogenesis protein dephosphorylation dephosphorylation peptidyl-tyrosine dephosphorylation phosphate-containing compound metabolic process Components receptor complex integral component of plasma membrane
General Function	Transmembrane receptor protein tyrosine phosphatase activity
Specific Function	Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Pfam Domain Function	fn3 (PF00041 ) Y_phosphatase (PF00102 )
Transmembrane Regions	1622-1642
GenBank Protein ID	35788
UniProtKB ID	P23467
UniProtKB Entry Name	PTPRB_HUMAN
Cellular Location	Membrane
Gene sequence	>lcl\|BSEQ0019468\|Receptor-type tyrosine-protein phosphatase beta (PTPRB) ATGGAGGCTGAATTTTACATGGTGATTCTTACCTGCTTGATCTTCAGGAACTCAGAAGGG TTTCAGATTGTCCATGTCCAGAAACAACAGTGTCTTTTCAAAAATGAGAAAGTGGTCGTG GGCTCATGCAACAGGACCATCCAGAACCAGCAGTGGATGTGGACTGAGGATGAAAAGCTC CTTCATGTTAAATCTGCACTGTGCTTGGCCATCTCCAACTCTTCCCGCGGCCCCTCCCGC TCAGCCATCTTGGACCGCTGTTCCCAGGCACCCCGATGGACCTGCTATGATCAGGAAGGC TTCCTTGAGGTGGAAAATGCCTCTCTCTTTCTCCAGAAACAAGGCTCCAGAGTAGTGGTC AAGAAGGCCAGGAAATACCTCCATAGCTGGATGAAAATAGATGTCAACAAGGAGGGAAAA CTGGTCAATGAAAGCCTCTGTTTACAAAAAGCTGGCCTGGGAGCAGAAGTTTCGGTGAGG AGCACTAGAAACACGGCTCCACCCCAGATTCTCACTACCTTTAATGCAGTTCCAGATGGC CTGGTATTCCTTATTAGGAATACCACAGAGGCCTTCATCAGAAATGCTGCAGAAAACTAC AGCCAAAACAGCAGCGAGAGGCAGCATCCCAATCTGCACATGACTGGAATTACAGACACA TCATGGGTTTTGTCGACTACTCAGCCCTTCTCCAGCACCACTGAAGAGACTGGACTGGCG GAGCCAGAGAGATGTAACTTCACCCTGGCGGAGTCCAAGGCCTCCAGCCATTCTGTGTCT ATCCAGTGGAGAATTTTGGGCTCACCCTGTAACTTTAGCCTCATCTATAGCAGTGACACC CTGGGGGCCGCGTTGTGCCCTACCTTTCGGATAGACAACACCACATACGGATGTAACCTT CAAGATTTACAAGCAGGAACCATCTATAACTTCAGGATTATTTCTCTGGATGAAGAGAGA ACAGTGGTCTTGCAAACAGATCCTTTACCTCCTGCTAGGTTTGGAGTCAGTAAAGAGAAG ACGACTTCAACCAGCTTGCATGTTTGGTGGACTCCTTCTTCCGGAAAAGTCACCTCATAT GAGGTGCAATTATTTGATGAAAATAACCAAAAGATACAGGGGGTTCAAATTCAAGAAAGT ACTTCATGGAATGAATACACTTTTTTCAATCTCACTGCTGGTAGTAAATACAATATTGCC ATCACAGCTGTTTCTGGAGGAAAACGTTCTTTTTCAGTTTATACCAATGGATCAACAGTG CCATCTCCAGTGAAAGATATTGGTATTTCCACAAAAGCCAATTCTCTCCTGATTTCCTGG TCCCATGGTTCTGGGAATGTGGAACGATACCGGCTGATGCTAATGGATAAAGGGATCCTA GTTCATGGCGGTGTTGTGGACAAACATGCTACTTCCTATGCTTTTCACGGGCTGACCCCT GGCTACCTCTACAACCTCACTGTTATGACTGAGGCTGCAGGGCTGCAAAACTACAGGTGG AAACTAGTCAGGACAGCCCCCATGGAAGTCTCAAATCTGAAGGTGACAAATGATGGCAGT TTGACCTCTCTAAAAGTCAAATGGCAAAGACCTCCTGGAAATGTGGATTCTTACAATATC ACCCTGTCTCACAAAGGGACCATCAAGGAATCCAGAGTATTAGCACCTTGGATTACTGAA ACTCACTTTAAAGAGTTAGTCCCCGGTCGACTTTATCAAGTTACTGTCAGCTGTGTCTCT GGTGAACTGTCTGCTCAGAAGATGGCAGTGGGCAGAACATTTCCAGACAAAGTTGCAAAC CTGGAGGCAAACAATAATGGCAGGATGAGGTCTCTTGTAGTGAGCTGGTCGCCCCCTGCT GGAGACTGGGAGCAGTATCGGATCCTACTCTTCAATGATTCTGTGGTGCTGCTCAACATC ACTGTGGGAAAGGAAGAAACACAGTATGTCATGGATGACACGGGGCTCGTACCGGGAAGA CAGTATGAGGTGGAAGTCATTGTTGAGAGTGGAAATTTGAAGAATTCTGAGCGTTGCCAA GGCAGGACAGTCCCCCTGGCTGTCCTCCAGCTTCGTGTCAAACATGCCAATGAAACCTCA CTGAGTATCATGTGGCAGACCCCTGTAGCAGAATGGGAGAAATACATCATTTCCCTAGCT GACAGAGACCTCTTACTGATCCACAAGTCACTCTCCAAAGATGCCAAAGAATTCACTTTT ACTGACCTGGTGCCTGGACGAAAATACATGGCTACAGTCACCAGTATTAGTGGAGACTTA AAAAATTCCTCTTCAGTAAAAGGAAGAACAGTGCCTGCCCAAGTGACTGACTTGCATGTG GCCAACCAAGGAATGACCAGTAGTCTGTTTACTAACTGGACCCAGGCACAAGGAGACGTA GAATTTTACCAAGTCTTACTGATCCATGAAAATGTGGTCATTAAAAATGAAAGCATCTCC AGTGAGACCAGCAGATACAGCTTCCACTCTCTCAAGTCCGGCAGCCTGTACTCCGTGGTG GTAACAACAGTGAGTGGAGGGATCTCTTCCCGACAAGTGGTTGTGGAGGGAAGAACAGTC CCTTCCAGTGTGAGTGGAGTAACGGTGAACAATTCCGGTCGTAATGACTACCTCAGCGTT TCCTGGCTGCTGGCGCCCGGAGATGTGGATAACTATGAGGTAACATTGTCTCATGACGGC AAGGTGGTTCAGTCCCTTGTCATTGCCAAGTCTGTCAGAGAATGTTCCTTCAGCTCCCTC ACCCCAGGCCGCCTCTACACCGTGACCATAACTACAAGGAGTGGCAAGTATGAAAATCAC TCCTTCAGCCAAGAGCGGACAGTGCCTGACAAAGTCCAGGGAGTCAGTGTTAGCAACTCA GCCAGGAGTGACTATTTAAGGGTATCCTGGGTGCATGCCACTGGAGACTTTGATCACTAT GAAGTCACCATTAAAAACAAAAACAACTTCATTCAAACTAAAAGCATTCCCAAGTCAGAA AACGAATGTGTATTTGTTCAGCTAGTCCCTGGACGGTTGTACAGTGTCACTGTTACTACA AAAAGTGGACAATATGAAGCCAATGAACAAGGGAATGGGAGAACAATTCCAGAGCCTGTT AAGGATCTAACATTGCGCAACAGGAGCACTGAGGACTTGCATGTGACTTGGTCAGGAGCT AATGGGGATGTCGACCAATATGAGATCCAGCTGCTCTTCAATGACATGAAAGTATTTCCT CCTTTTCACCTTGTAAATACCGCAACCGAGTATCGATTTACTTCCCTAACACCAGGCCGC CAATACAAAATTCTTGTCTTGACGATTAGCGGGGATGTACAGCAGTCAGCCTTCATTGAG GGCTTCACAGTTCCTAGTGCTGTCAAAAATATTCACATTTCTCCCAATGGAGCAACAGAT AGCCTGACGGTGAACTGGACTCCTGGTGGGGGAGACGTTGATTCCTACACGGTGTCGGCA TTCAGGCACAGTCAAAAGGTTGACTCTCAGACTATTCCCAAGCACGTCTTTGAGCACACG TTCCACAGACTGGAGGCCGGGGAGCAGTACCAGATCATGATTGCCTCAGTCAGCGGGTCC CTGAAGAATCAGATAAATGTGGTTGGGCGGACAGTTCCAGCATCTGTCCAAGGAGTAATT GCAGACAATGCATACAGCAGTTATTCCTTAATAGTAAGTTGGCAAAAAGCTGCTGGTGTG GCAGAAAGATATGATATCCTGCTTCTAACTGAAAATGGAATCCTTCTGCGCAACACATCA GAGCCAGCCACCACTAAGCAACACAAATTTGAAGATCTAACACCAGGCAAGAAATACAAG ATACAGATCCTAACTGTCAGTGGAGGCCTCTTTAGCAAGGAAGCCCAGACTGAAGGCCGA ACAGTCCCAGCAGCTGTCACCGACCTGAGGATCACAGAGAACTCCACCAGGCACCTGTCC TTCCGCTGGACCGCCTCAGAGGGGGAGCTCAGCTGGTACAACATCTTTTTGTACAACCCA GATGGGAATCTCCAGGAGAGAGCTCAAGTTGACCCACTAGTCCAGAGCTTCTCTTTCCAG AACTTGCTACAAGGCAGAATGTACAAGATGGTGATTGTAACTCACAGTGGGGAGCTGTCT AATGAGTCTTTCATATTTGGTAGAACAGTCCCAGCCTCTGTGAGTCATCTCAGGGGGTCC AATCGGAACACGACAGACAGCCTTTGGTTCAACTGGAGTCCAGCCTCTGGGGACTTTGAC TTTTATGAGCTGATTCTCTATAATCCCAATGGCACAAAGAAGGAAAACTGGAAAGACAAG GACCTGACGGAGTGGCGGTTTCAAGGCCTTGTTCCTGGAAGGAAGTACGTGCTGTGGGTG GTAACTCACAGTGGAGATCTCAGCAATAAAGTCACAGCGGAGAGCAGAACAGCTCCAAGT CCTCCCAGTCTTATGTCATTTGCTGACATTGCAAACACATCCTTGGCCATCACGTGGAAA GGGCCCCCAGACTGGACAGACTACAACGACTTTGAGCTGCAGTGGTTGCCCAGAGATGCA CTTACTGTCTTCAACCCCTACAACAACAGAAAATCAGAAGGACGCATTGTGTATGGTCTT CGTCCAGGGAGATCCTATCAATTCAACGTCAAGACTGTCAGTGGTGATTCCTGGAAAACT TACAGCAAACCAATTTTTGGATCTGTGAGGACAAAGCCTGACAAGATACAAAACCTGCAT TGCCGGCCTCAGAACTCCACGGCCATTGCCTGTTCTTGGATCCCTCCTGATTCTGACTTT GATGGTTATAGTATTGAATGCCGGAAAATGGACACCCAAGAAGTTGAGTTTTCCAGAAAG CTGGAGAAAGAAAAATCTCTGCTCAACATCATGATGCTAGTGCCCCATAAGAGGTACCTG GTGTCCATCAAAGTGCAGTCGGCCGGCATGACCAGCGAGGTGGTTGAAGACAGCACTATC ACAATGATAGACCGCCCCCCTCCTCCACCCCCACACATTCGTGTGAATGAAAAGGATGTG CTAATTAGCAAGTCTTCCATCAACTTTACTGTCAACTGCAGCTGGTTCAGCGACACCAAT GGAGCTGTGAAATACTTCACAGTGGTGGTGAGAGAGGCTGATGGCAGTGATGAGCTGAAG CCAGAACAGCAGCACCCTCTCCCTTCCTACCTGGAGTACAGGCACAATGCCTCCATTCGG GTGTATCAGACTAATTATTTTGCCAGCAAATGTGCCGAAAATCCTAACAGCAACTCCAAG AGTTTTAACATTAAGCTTGGAGCAGAGATGGAGAGCCTAGGTGGAAAATGCGATCCCACT CAGCAAAAATTCTGTGATGGACCACTGAAGCCACACACTGCCTACAGAATCAGCATTCGA GCTTTTACACAGCTCTTTGATGAGGACCTGAAGGAATTCACAAAGCCACTCTATTCAGAC ACATTTTTTTCTTTACCCATCACTACTGAATCAGAGCCCTTGTTTGGAGCTATTGAAGGT GTGAGTGCTGGTCTGTTTTTAATTGGCATGCTAGTGGCTGTTGTTGCCTTATTGATCTGC AGACAGAAAGTGAGCCATGGTCGAGAAAGACCCTCTGCCCGTCTGAGCATTCGTAGGGAT CGACCATTATCTGTCCACTTAAACCTGGGCCAGAAAGGTAACCGGAAAACTTCTTGTCCA ATAAAAATAAATCAGTTTGAAGGGCATTTCATGAAGCTACAGGCTGACTCCAACTACCTT CTATCCAAGGAATACGAGGAGTTAAAAGACGTGGGCCGAAACCAGTCATGTGACATTGCA CTCTTGCCGGAGAATAGAGGGAAAAATCGATACAACAATATATTGCCCTATGATGCCACG CGAGTGAAGCTCTCCAATGTAGATGATGATCCTTGCTCTGACTACATCAATGCCAGCTAC ATCCCTGGCAACAACTTCAGAAGAGAATACATTGTCACTCAGGGACCGCTTCCTGGCACC AAGGATGACTTCTGGAAAATGGTGTGGGAACAAAACGTTCACAACATCGTCATGGTGACC CAGTGTGTTGAGAAGGGCCGAGTAAAGTGTGACCATTACTGGCCAGCGGACCAGGATTCC CTCTACTATGGGGACCTCATCCTGCAGATGCTCTCAGAGTCCGTCCTGCCTGAGTGGACC ATCCGGGAGTTTAAGATATGCGGTGAGGAACAGCTTGATGCACACAGACTCATCCGCCAC TTTCACTATACGGTGTGGCCAGACCATGGAGTCCCAGAAACCACCCAGTCTCTGATCCAG TTTGTGAGAACTGTCAGGGACTACATCAACAGAAGCCCGGGTGCTGGGCCCACTGTGGTG CACTGCAGTGCTGGTGTGGGTAGGACTGGAACCTTTATTGCATTGGACCGAATCCTCCAG CAGTTAGACTCCAAAGACTCTGTGGACATTTATGGAGCAGTGCACGACCTAAGACTTCAC AGGGTTCACATGGTCCAGACTGAGTGTCAGTATGTCTACCTACATCAGTGTGTAAGAGAT GTCCTCAGAGCAAGAAAGCTACGGAGTGAACAAGAAAACCCCTTGTTTCCAATCTATGAA AATGTGAATCCAGAGTATCACAGAGATCCAGTCTATTCAAGGCATTGA
GenBank Gene ID	X54131
GeneCard ID	Not Available
GenAtlas ID	Not Available
HGNC ID	HGNC:9665
Chromosome Location	12
Locus	12q15-q21
References	Krueger NX, Streuli M, Saito H: Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. EMBO J. 1990 Oct;9(10):3241-52. 2170109 Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. 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