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NameCytochrome c oxidase subunit 7B, mitochondrial
Synonyms
  • Cytochrome c oxidase polypeptide VIIb
Gene NameCOX7B
OrganismHuman
Amino acid sequence
>lcl|BSEQ0020730|Cytochrome c oxidase subunit 7B, mitochondrial
MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQV
GIEWNLSPVGRVTPKEWRNQ
Number of residues80
Molecular Weight9160.485
Theoretical pI10.87
GO Classification
Functions
  • cytochrome-c oxidase activity
Processes
  • gene expression
  • small molecule metabolic process
  • transcription initiation from RNA polymerase II promoter
  • cellular metabolic process
  • respiratory electron transport chain
  • hydrogen ion transmembrane transport
  • central nervous system development
Components
  • respiratory chain complex IV
  • mitochondrial respiratory chain
  • mitochondrion
  • mitochondrial inner membrane
  • integral component of membrane
General FunctionCytochrome-c oxidase activity
Specific FunctionThis protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. Plays a role in proper central nervous system (CNS) development in vertebrates.
Pfam Domain Function
Transmembrane Regions33-59
GenBank Protein ID30151
UniProtKB IDP24311
UniProtKB Entry NameCOX7B_HUMAN
Cellular LocationMitochondrion inner membrane
Gene sequence
>lcl|BSEQ0020731|Cytochrome c oxidase subunit 7B, mitochondrial (COX7B)
ATGTTTCCCTTGGTCAAAAGCGCACTAAATCGTCTCCAAGTTCGAAGCATTCAGCAAACA
ATGGCAAGGCAGAGCCACCAGAAACGTACACCTGATTTTCATGACAAATACGGTAATGCT
GTATTAGCTAGTGGAGCCACTTTCTGTATTGTTACATGGACATATGTAGCAACACAAGTC
GGAATAGAATGGAACCTGTCCCCTGTTGGCAGAGTTACCCCAAAGGAATGGAGGAATCAG
TAA
GenBank Gene IDZ14244
GeneCard IDNot Available
GenAtlas IDNot Available
HGNC IDHGNC:2291
Chromosome LocationX
LocusNot Available
References
  1. Sadlock JE, Lightowlers RN, Capaldi RA, Schon EA: Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase. Biochim Biophys Acta. 1993 Feb 20;1172(1-2):223-5. 8382530
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